Immunodeficiency News and Research

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Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent.

Common subcutaneous antibody therapy for immunodeficient patients has anti-SARS-CoV-2 antibodies

Researchers at the University of Texas Medical Branch recently confirmed the presence of neutralizing antibodies to SARS--COV-2 in a common subcutaneous antibody therapy (Hizentra) used to treat immunocompromised or immunodeficient patients, citing its protective benefits to the immunocompromised patient community.

25 Apr 2022

World Malaria Day 2022: How the knockdown of P. falciparum RAP01 and RAP21 proteins could lead to novel antimalarial therapeutics

As part of World Malaria Day 2022, we interview Karine Le Roch PH.D., about her latest research into how novel antimalarial therapeutic strategies could be on the horizon, after identifying two proteins that are critical to the survival of the malaria parasite, Plasmodium falciparum.

25 Apr 2022

Continual genomic surveillance in Africa provides insights into evolving SARS-CoV-2 pandemic

Researchers described how SARS-CoV-2 genomic sequencing efforts in Africa helped identify two of the five SARS-CoV-2 VOCs, and their early analysis.

22 Apr 2022

Advancements in HIV science

As far as viruses go, human immunodeficiency virus (HIV) is quite simple. About 100,000 times smaller than a red blood cell, the virus expresses just a dozen proteins, yet it can establish a lifelong infection that, if left untreated, causes acquired immunodeficiency syndrome (AIDS) and death.

20 Apr 2022

Fully vaccinated HIV patients may be less susceptible to develop severe breakthrough SARS-CoV-2 infection

A new study found that the risk of severe breakthrough infection of SARS-CoV-2 is low among fully vaccinated HIV patients.

19 Apr 2022

Intensity and longevity of SARS-CoV-2 vaccination response in patients with immune-mediated inflammatory disease

Researchers investigated the longevity and intensity of the SARS-CoV-2 vaccine immune response in patients suffering from immune-mediated inflammatory diseases.

15 Apr 2022

SARS-CoV-2 mutations change proteasome processing to alter CD8+ T cell responses

Researchers identified mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleoproteins (NP) epitope flanking regions and their potential effects on CD8+ T cell activation.

12 Apr 2022

Immunocompromised hosts with Delta/Omicron co-infections

A recent study posted to the medRxiv* preprint server examined clinical cases of co-infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta/Omicron variants and Omicron BA.1/ BA.2 sublineages in immunocompromised (IC) patients.

10 Apr 2022

The effect of unsuppressed HIV on T-cell response to COVID-19

A new study evaluates the impact of HIV infection on SARS-CoV-2 T-cell responses during the first and second waves of COVID-19 in South Africa.

10 Apr 2022

Improved seroprevalence and antibody response after third COVID-19 vaccination

Researchers evaluated the immunogenicity of a third COVID-19 vaccination in antibody deficient subjects.

8 Apr 2022

Key protein could be a novel target for treatment of patients with B cell signaling deficiencies

The rules to the kids' game "red light, green light" are easy to follow: red always means stop, and green always means go. But now, researchers from Japan have found that a key protein involved in B cell signaling acts as both a red light to signaling in healthy cells and a green light to signaling in immune-deficient cells.

4 Apr 2022

SARS-CoV-2 prevalence during the initial period of SARS-CoV-2 Omicron variant emergence in Finland

A recent study presented the rapid spike in COVID-19 seroprevalence during the emergence of the Omicron variant in Finland.

4 Apr 2022

Acute respiratory distress syndrome may increase death risk among young COVID-19 patients

A new study estimated the risk and prevalence of acute respiratory distress syndrome in hospitalized young adults with SARS-CoV-2 infection.

4 Apr 2022

mRNA-1273 and BNT162b2 COVID-19 vaccines induce slightly different immune responses

In a recent study published in the journal Science, researchers observed differential effector functions of antibodies elicited by Pfizer’s BNT162b2 and Moderna’s messenger ribonucleic acid (mRNA)-1273 coronavirus disease 2019 (COVID-19) vaccines.

4 Apr 2022

Scientists use new CRISPR gene-editing approach to find paths toward possible HIV cure

Scientists at Northwestern Medicine are using new advances in CRISPR gene-editing technology to uncover new biology that could lead to longer-lasting treatments and new therapeutic strategies for Human Immunodeficiency Virus (HIV).

1 Apr 2022

Research illuminates why immune disorders affect only one of two identical twins

Scientists have long queried the causes of immune disorders in only one of two identical twins with identical genes. New research from the Wellcome Sanger Institute, the Josep Carreras Leukaemia Research Institute in Spain and their collaborators, has found the answer lies in both alterations in immune cell-cell communication and the epigenome, the host of biological processes that regulate how our genes function.

1 Apr 2022

Immunodeficiency News and Research

Further Reading

Common subcutaneous antibody therapy for immunodeficient patients has anti-SARS-CoV-2 antibodies

World Malaria Day 2022: How the knockdown of P. falciparum RAP01 and RAP21 proteins could lead to novel antimalarial therapeutics

Continual genomic surveillance in Africa provides insights into evolving SARS-CoV-2 pandemic

Advancements in HIV science

Fully vaccinated HIV patients may be less susceptible to develop severe breakthrough SARS-CoV-2 infection

Intensity and longevity of SARS-CoV-2 vaccination response in patients with immune-mediated inflammatory disease

SARS-CoV-2 mutations change proteasome processing to alter CD8+ T cell responses

Immunocompromised hosts with Delta/Omicron co-infections

The effect of unsuppressed HIV on T-cell response to COVID-19

Improved seroprevalence and antibody response after third COVID-19 vaccination

Key protein could be a novel target for treatment of patients with B cell signaling deficiencies

SARS-CoV-2 prevalence during the initial period of SARS-CoV-2 Omicron variant emergence in Finland

Acute respiratory distress syndrome may increase death risk among young COVID-19 patients

mRNA-1273 and BNT162b2 COVID-19 vaccines induce slightly different immune responses

Scientists use new CRISPR gene-editing approach to find paths toward possible HIV cure

Research illuminates why immune disorders affect only one of two identical twins

Clinical trials for experimental HIV vaccines based on mRNA technology begin in United States

Study shows that the SARS-CoV-2 envelope protein potently restricts HIV-1 infection

Furin inhibitors as potential therapies to combat SARS-CoV-2 and other diseases

Penn researchers generate functional CAR T cells with enhanced anti-tumor potency in 24 hours

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