Spleen News and Research

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Innovative magnetic nanoparticles show potential for PET/MRI bimodal imaging applications

In a paper published in the American Chemical Society journal researchers from Bourgogne University showed that the use of superparamagnetic iron oxide nanoparticles using multi modal – PET/MRI - showed promising improvements in imaging capabilities.

From MR Solutions 15 May 2019

Increasing early beta-cell proliferation could halt development of type 1 diabetes

Many in-development cures for type 1 diabetes have understandably focused on tackling the autoimmune aspect of the disease before figuring out a way to replace the destroyed beta cells. But what if focusing on the beta cells first could prevent their destruction altogether?

7 May 2019

Scientists develop maps of two melatonin receptors vital for sleep, other biological processes

An international team of researchers used an X-ray laser at the Department of Energy’s SLAC National Accelerator Laboratory to create the first detailed maps of two melatonin receptors that tell our bodies when to go to sleep or wake up and guide other biological processes.

26 Apr 2019

New blood-cell analysis device helps better understand causes and mechanics of rare anemia

An EU-funded project has developed a blood-cell analysis device that helps doctors and scientists better understand the causes and mechanics of rare forms of anemia - potentially speeding up the development of new treatments adjusted to the needs of patients with these diseases.

25 Apr 2019

UAB receives $17 million grant to explore immune cells in inaccessible tissues of the human body

University of Alabama at Birmingham researchers will receive $17.8 million in federal funding to attack a key "knowledge gap" in human immunology -- how the B cells and antibody-secreting cells that reside in tissues and organs differ from those found in blood.

23 Apr 2019

Removing damaged mitochondria may relieve chronic inflammatory conditions

Researchers have discovered a potential new way to treat chronic inflammatory diseases, by eliminating damaged mitochondria before they trigger excessive inflammation.

12 Apr 2019

Researchers discover unique approach to treat some chronic inflammatory diseases

Inflammation is a balanced physiological response -- the body needs it to eliminate invasive organisms and foreign irritants, but excessive inflammation can harm healthy cells, contributing to aging and chronic diseases.

12 Apr 2019

Researchers find presence of Aire gene in lymph nodes

The thymus is the organ in which T cells differentiate. T cells express various T cell receptors for reacting with various pathogenic microbes and viruses.

11 Apr 2019

Researchers identify alternative treatment for bacterial meningitis

With the increasing threat of antibiotic resistance, there is a growing need for new treatment strategies against life threatening bacterial infections.

10 Apr 2019

Research findings change misconception on white blood cell trafficking to spleen

Contrary to prior belief, the white blood cells enter the spleen primarily via vessels in the red pulp. The research results change thoroughly our perception of the spleen producing antibodies vital for the human body.

3 Apr 2019

New molecular mechanism involved in pancreas repair identified

Ramón Muñoz-Chápuli and Rita Carmona, researchers of the UMA Department of Animal Biology, have identified a new molecular mechanism involved in pancreas repair.

25 Mar 2019

A novel approach for treating inflammatory arthritis

Researchers at the University of Minnesota, in collaboration with researchers at Medtronic, have shown that noninvasive daily ultrasound stimulation of the spleen in mice with inflammatory arthritis resulted in significantly less joint swelling compared to arthritic mice that were not treated.

15 Mar 2019

Researchers define pathway that helps us make antibodies

Our bodies are continuously concocting specific antibodies to thwart invaders like a virus or even pollen, and scientists have new information about how the essential production gets fired up and keeps up.

13 Mar 2019

Study reveals how a regulatory molecule ensures appropriate supply of blood cells

The body needs to create a continuous supply of blood cells to enter circulation. Blood cells have a wide variety of functions ranging from supplying oxygen to tissues, fighting infections, and enabling the blood to clot upon injury.

13 Mar 2019

Mechanism through which bacteria attack the immune system discovered

A research team led by Prof. Dr. Winfried Römer and Dr. Elias Hobeika from the University of Freiburg and the University Medical Center in Ulm has discovered a mechanism with which bacteria activate white blood cells and attack an organism's immune system. The scientists recently published the results in the journal Science Signaling.

7 Mar 2019

CAR-T cell therapy could be on the horizon for patients with lupus

Researchers have developed a novel CAR-T cell therapy that can reduce B cell numbers known to cause the inflammatory responses in lupus.

7 Mar 2019

Study finds how miR-132 acts as ‘handbrake’ on our immune system

Researchers have discovered how a tiny molecule known as miR-132 acts as a "handbrake" on our immune system - helping us fight infection.

5 Mar 2019

Aging and high-fat diet disrupt gut microbiome to cause inflammation in heart failure

Growing older and a high-fat diet enriched with omega 6 fatty acids are major contributors to health risks ranging from diabetes to heart failure. How these two factors regulate the immune response is not well-understood.

1 Mar 2019

Research shows how common fungus gets the flexibility to live in different host environments

The fungus Candida albicans is found in the gastrointestinal tract of about half of healthy adults with little if any effect, yet it also causes an oft-fatal blood infection among patients with compromised immune systems, including those with HIV/AIDS.