Innovative magnetic nanoparticles show potential for PET/MRI bimodal imaging applications

In a paper published in the American Chemical Society journal researchers from Bourgogne University showed that the use of superparamagnetic iron oxide nanoparticles (NPs) using multi modal – PET/MRI - showed promising improvements in imaging capabilities.

Using an MR Solutions, cryogen free, 3T scanner with a PET clip on the sequential images were found to be highly beneficial providing high spatial resolution, high sensitivity, high technical maturity with a low radiation dose.

Professor Nadine Millot Principal Investigator on the Study commented:

The combination of simultaneous MRI/PET imaging is very attractive because it allies the high resolution of MRI with the high sensitivity of PET to obtain accurate anatomical and quantitative information at the same time.”

This pioneering agent highlights activity in the liver, spleen, lungs and kidneys before being gradually excreted from the body with no cytotoxicity observed.

This is the first successful grafting of PEG and MANOTA chelator on prefunctionalized iron oxide NPs synthesized under continuous hydrothermal conditions for bimodal PET/MRI imaging and shows the potential benefits.

MR Solutions remains the only company with commercial installations of cryogen free MRI scanners – from 3T to 7T. All of these scanners can be fitted with either clip-on PET scanners for sequential scanning or inserted into the bore to provide simultaneous scanning.

The same PET clip-ons can also be used on the recently launched range of MR’s CT scanners.

Source:

MR Solutions

Journal reference:

Millot, N. et al. (2019) Innovative Magnetic Nanoparticles for PET/MRI Bimodal Imaging. ACS Omega. doi.org/10.1021/acsomega.8b03283