Transcription Factors News and Research

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Researchers elucidate enzymes that control long-term memory, learning process in the brain

When we first purchase a smart phone, all of our settings and applications are the same. But as time passes, everyone's phones will change drastically as we adapt them to our own individual needs and preferences. In the same way, our memories and life experiences are loaded into our brains, making one person unique from another.

2 Oct 2019

Researchers propose potential treatment for Ewing sarcomas

Ewing sarcoma is a bone cancer that appears mainly in teenagers. Due to a single defective gene, once it spreads to distant organs it is hard to treat. Researchers at the Weizmann Institute of Science have discovered molecular interactions underlying Ewing sarcomas and proposed a potential treatment, which has shown promise in a study in mice.

2 Oct 2019

Cardiac cells derived from skin samples help unravel genetic underpinnings of heart function

Genome-wide association studies have uncovered more than 500 genetic variants linked to heart function, everything from heart rate to irregular rhythms that can lead to stroke, heart failure or other complications.

30 Sep 2019

New trial shows improved survival for patients with advanced colorectal BRAF-mutant cancer

A clinical trial has shown that using a combination of three drugs that target a BRAF gene mutation in patients with mCRC effectively boosts overall survival.

30 Sep 2019

Temporal fluctuations in protein concentrations can determine fate of stem cells

How do temporal variations in protein concentrations affect biology? It's a question that biologists have only recently begun to address, and the findings are increasingly showing that random temporal changes in the amount of certain proteins play a direct and significant role on biological processes.

26 Sep 2019

Antioxidant compound proves effective in kidney ischemia-reperfusion treatment

Russian researchers from the Moscow Institute of Physics and Technology, the Institute of Cell Biophysics, and elsewhere have shown an antioxidant compound known as peroxiredoxin to be effective in treating kidney injury in mice.

9 Sep 2019

New study helps explain why lung tumors turn aggressive

Lung cancer is the number 1 killer among cancers, especially when it is of the non-small cell type. Among these, adenocarcinomas are the most common and aggressive type. These tumors also show a strong tendency to show dedifferentiation, or loss of the features that characterize a mature lung cell.

28 Aug 2019

Study maps bone marrow niche populations and their differentiation paths

Bone marrow contains biological factories, which pump out billions of new blood cells daily. The non-blood cells that maintain this production also have the potential to produce bone, fat and cartilage.

1 Aug 2019

Slug serves as 'command central' for determining breast stem cell health

A new study published in Cell Reports found that a transcription factor called Slug serves as 'command central' for determining breast stem cell health, regulating both stem cell activity and repair of DNA damage.

17 Jul 2019

Study shows potential culprit behind Lupus

A team of researchers at the Emory University School of Medicine show that patients with SLE or lupus, have abnormal activation of B cells, which is part of the body’s immune system

8 Jul 2019

Mice study suggests potential treatment approach for MS in humans

For decades medical researchers have known that an effective way to combat multiple sclerosis (MS) would be to suppress the human immune system, since the debilitating disease is caused by the immune system 'mistakenly' attacking tissues in the spine and brain.

3 Jul 2019

Disrupting ChIP Assay Technology with New Advancements

The Chromatrap ChIP technology is a bead-free method of performing ChIP. The potential of the technology emerged from our capabilities in manufacturing porous plastic filters for the filtration and separation of biological materials.

From Chromatrap® - Porvair Sciences Ltd 27 Jun 2019

ChIP-seq kit maximizes chromatin-antibody binding and capture

Optimizing protein orientation for maximum chromatin-antibody binding and capture enables Chromatrap® ChIP-seq kits to offer market leading sensitivity.

From Chromatrap® - Porvair Sciences Ltd 19 Jun 2019

UC Santa Cruz researchers determine structure of a 'master switch' for cell division

Unregulated cell division is a hallmark of cancer, and one of the key proteins involved in controlling cell division is called FoxM1.

29 May 2019

Genetically eliminating TOX factors improves eradication of solid tumors in CAR T model

A decade ago researchers announced development of a cancer immunotherapy called CAR (for chimeric antigen receptor)-T, in which a patient is re-infused with their own genetically modified T cells equipped to mount a potent anti-tumor attack.

28 May 2019

Scientists uncover unique set of genes that play a role in muscle cellular gene regulation

York University scientists have uncovered a unique set of genes that play a role in muscle cellular gene expression and differentiation which could lead to new therapeutic targets to prevent the spread of muscle cancer.

23 May 2019

Honey from strawberry trees stops cell proliferation in colon cancer lines

Spanish and Italian researchers have proven that when honey from strawberry trees, a product typical of Mediterranean areas, is added to colon cancer cells grown in the laboratory, cell proliferation is stopped.

21 May 2019

Synthetic biologists add analog-to-digital signal processing to genetic circuitry of living cells

Synthetic biologists have added high-precision analog-to-digital signal processing to the genetic circuitry of living cells.

19 Apr 2019

KZFPs play a key role in the regulation of human genome

The human genome is fascinating. Once predicted to contain about a hundred thousand protein-coding genes, it now seems that the number is closer to twenty thousand, and maybe less.

19 Apr 2019

Researchers discover how specific mutation obstructs healthy blood cell maturation

In the veins, stem cells constantly mature and develop into different blood cells that are necessary for the body to work properly.

5 Apr 2019