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Bile acids help norovirus to infect cells of the small intestine

A new study led by researchers at Baylor College of Medicine and published in the Proceedings of the National Academy of Sciences reveals that human noroviruses, the leading viral cause of foodborne illness and acute diarrhea around the world, infect cells of the small intestine by piggybacking on a normal cellular process called endocytosis that cells use to acquire materials from their environment.

31 Dec 2019

Scientists identify molecules capable of inhibiting DNA methylation, effectively killing malaria parasites

Parasites in the genus Plasmodium, which cause malaria, are transmitted to humans through bites from infected mosquitoes.

31 Dec 2019

A reality check on artificial intelligence: Are health care claims overblown?

Health products powered by artificial intelligence, or AI, are streaming into our lives, from virtual doctor apps to wearable sensors and drugstore chatbots.

30 Dec 2019

Scientists discover potential drug compounds that target common type of liver cancer

Scientists from the Cancer Science Institute of Singapore at the National University of Singapore, and the Agency for Science, Technology and Research (A*STAR)'s Genome Institute of Singapore have discovered four potential drug compounds that target hepatocellular carcinoma, the most common type of liver cancer.

30 Dec 2019

A new deep learning approach to predict disease-associated mutations

During the past years, artificial intelligence (AI) -- the capability of a machine to mimic human behavior -- has become a key player in high-techs like drug development projects.

28 Dec 2019

Recommended amounts of physical activity associated with reduced risk for seven cancers

A pooled analysis of nine prospective studies involving more than 750,000 adults finds that recommended amounts of leisure-time physical activity were linked to a lower risk for seven cancers, with several cancer types having a 'dose/response' relationship.

27 Dec 2019

A HSC surface marker plays key role in ontogeny of hematopoiesis

A group of researchers at Osaka University revealed that ESAM (Endothelial cell-selective adhesion molecule), a surface marker for hematopoietic stem cells (HSCs) and vascular endothelial cells (ECs), played an important role in the ontogeny of hematopoiesis in mice, particularly in the development of adult-type erythropoiesis.

26 Dec 2019

Synthetic mRNA nanoparticles restore tumor suppressor gene, make cancer cells susceptible to drugs

In preclinical experiments, investigators restored p53 using synthetic mRNA nanoparticles, making lung and liver cancer cells susceptible to available cancer drugs.

23 Dec 2019

Research shows how the hepatitis D virus copies itself

A team of researchers has discovered how one crucial step occurs in the lifecycle of the hepatitis D virus (HDV), which causes the widespread and hard to treat liver inflammation called hepatitis D. The study, which was published recently in the Journal of Virology, could help develop antiviral therapy to control this disease.

22 Dec 2019

New software helps prevent ICU delirium and improve patient outcomes

Intensive care unit delirium, a fertile area of clinical research and patient care innovation associated with Vanderbilt University Medical Center, is beginning to reshape how commercial electronic health record systems are engineered with regard to intensive care.

22 Dec 2019

Fat over-spills from the liver into the pancreas trigger Type 2 diabetes

For the first time, scientists have been able to observe people developing Type 2 diabetes - and confirmed that fat over-spills from the liver into the pancreas, triggering the chronic condition.

22 Dec 2019

Longevity protein SIRT6 also plays crucial role in burning and regulating liver fat metabolism

Fatty liver, or hepatic steatosis, which develops when the body produces too much fat or doesn't metabolize fat efficiently enough, affects around 25% of the global population. Excess fat is stored in liver cells, where it accumulates and can cause fatty liver and other diseases.

22 Dec 2019

UTHealth scientist receives NIH grants for liver injury research

Tiny solutions are being sought for big liver problems by a scientist at McGovern Medical School at The University of Texas Health Science Center at Houston.

21 Dec 2019

Kobe scientists develop mathematical model to predict cancer drug side effects

A research team at Kobe University Hospital have further illuminated the likelihood of cancer drug side effects that can occur due to genetic mutations in the drug-metabolizing enzyme.

20 Dec 2019

Triple transplant patients encourage people to register as organ and tissue donors

Four University of Chicago Medicine patients who received rare triple-organ transplants came together publicly for the first time to encourage people to register as organ and tissue donors, hoping to raise awareness about giving the gift of life during a holiday season focused on giving.

20 Dec 2019

Caffeine may offset some negative health effects of obesogenic diet

A new study in rats suggests that caffeine may offset some of the negative effects of an obesogenic diet by reducing the storage of lipids in fat cells and limiting weight gain and the production of triglycerides.

19 Dec 2019

Edematous severe acute malnutrition linked to DNA modification

A group led by researchers at Baylor College of Medicine has identified significant differences at the epigenetic level - the chemical tags in DNA that help regulate gene expression - between two clinically distinct forms of acute childhood malnutrition known as edematous severe acute malnutrition (ESAM) and non-edematous SAM (NESAM).

19 Dec 2019

Researchers reveal the mystery in replication cycle of hepatitis D virus

A team led by Professor Patrick Labonté at the Institut National de la Recherche Scientifique in Montreal, Canada has identified the role of a key process in the replication cycle of the hepatitis D virus, an infection that is still very difficult to cure and affects 15 to 20 million people worldwide.

19 Dec 2019

FDA approves new drug to treat adults with advanced urothelial or bladder cancer

The U.S. Food & Drug Administration granted accelerated approval to the drug enfortumab vedotin (EV) to treat adult patients with advanced urothelial or bladder cancer.

19 Dec 2019

Low diet quality, night eating during pregnancy linked to postpartum weight gain and retention

A study led by researchers from KK Women's and Children's Hospital (KKH) has found evidence that pregnant women who consume more of their daily food intake after 7.00 pm, and who consume lower quality diets during pregnancy, are more than three times more likely to experience postpartum weight retention of five kilograms or more, 18 months after giving birth.

19 Dec 2019

Liver News and Research

Bile acids help norovirus to infect cells of the small intestine

Scientists identify molecules capable of inhibiting DNA methylation, effectively killing malaria parasites

A reality check on artificial intelligence: Are health care claims overblown?

Scientists discover potential drug compounds that target common type of liver cancer

A new deep learning approach to predict disease-associated mutations

Recommended amounts of physical activity associated with reduced risk for seven cancers

A HSC surface marker plays key role in ontogeny of hematopoiesis

Synthetic mRNA nanoparticles restore tumor suppressor gene, make cancer cells susceptible to drugs

Research shows how the hepatitis D virus copies itself

New software helps prevent ICU delirium and improve patient outcomes

Fat over-spills from the liver into the pancreas trigger Type 2 diabetes

Longevity protein SIRT6 also plays crucial role in burning and regulating liver fat metabolism

UTHealth scientist receives NIH grants for liver injury research

Kobe scientists develop mathematical model to predict cancer drug side effects

Triple transplant patients encourage people to register as organ and tissue donors

Caffeine may offset some negative health effects of obesogenic diet

Edematous severe acute malnutrition linked to DNA modification

Researchers reveal the mystery in replication cycle of hepatitis D virus

FDA approves new drug to treat adults with advanced urothelial or bladder cancer

Low diet quality, night eating during pregnancy linked to postpartum weight gain and retention

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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