Immune System News and Research

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Nanovaccines and their immunomodulatory effect against human viruses

A review ]presented the primary progress of nanovaccines against the main viral illnesses.

13 Jan 2022

Moffitt experts provide insight on the role of B cell immunity in endometrial cancer

Endometrial cancer is the most common cancer of the female reproductive system. Patients who have active immune responses against cancer cells tend to have better outcomes, but much of what is known focuses on only one type of immune cell called T cells.

13 Jan 2022

Lack of evidence cross-reactive adaptive immune response is mechanism underlying COVID vaccine-induced myocarditis

Recently, the researchers from the USA, in their study published in the journal EBioMedicine, have conducted a sequence identity comparison and 3D protein structure comparison between the SARS-CoV-2 spike protein-derived peptides/protein and myocarditis-associated antigens and have found no significant enrichment in the frequency of spike-derived peptides similar to myocarditis-associated antigens that could have resulted in adaptive autoimmune responses leading to myocarditis.

12 Jan 2022

Study finds evidence for increased activity of the brain’s immune system long before dementia onset

Long before the onset of dementia, there is evidence for increased activity of the brain's immune system. Researchers from DZNE and the University Hospital Bonn come to this conclusion based on a study of more than 1,000 older adults.

12 Jan 2022

Living alone, serial break-ups may raise the levels of inflammatory markers in men

Living alone for several years and/or experiencing serial relationship break-ups are strongly linked to raised levels of inflammatory markers in the blood-but only in men-finds a large population study published online in the Journal of Epidemiology & Community Health.

12 Jan 2022

Regrowing knee cartilage can be a promising hop toward healing joints in humans

UConn bioengineers successfully regrew cartilage in a rabbit's knee, a promising hop toward healing joints in humans, they report in the 12 January issue of Science Translational Medicine.

12 Jan 2022

UCLA-led researchers improve method that was designed to kill HIV-infected cells

In a study using mice, a UCLA-led team of researchers have improved upon a method they developed in 2017 that was designed to kill HIV-infected cells.

12 Jan 2022

UCLA study provides new insights into molecular 'crosstalk' in pancreas cancer cells

Research led by scientists at the Jonsson Comprehensive Cancer Center (JCCC) at UCLA provides new insights into molecular "crosstalk" in pancreas cancer cells, identifying vulnerabilities that could provide a target for therapeutic drugs already being studied in several cancers.

12 Jan 2022

A common cold may boost the immune system against COVID-19

A recent groundbreaking research paper published in the journal Nature Communications reveals the association of circulating SARS-CoV-2-specific T cells at exposure with lack of infection – implying the protective role for cross-reactive immune T cells in coronavirus disease 2019 (COVID-19) and opening the door for second-generation vaccines that could circumvent spike-antibody immune escape variants.

11 Jan 2022

New technique could allow more diseases to be safely treated by nanomedicine

Researchers at Penn Medicine have discovered a new, more effective method of preventing the body's own proteins from treating nanomedicines like foreign invaders, by covering the nanoparticles with a coating to suppress the immune response that dampens the therapy's effectiveness.

11 Jan 2022

Study finds a subset of vascular macrophages to be powerful ally in the fight against atherosclerosis

A new study reveals the existence of a powerful ally in the fight against cardiovascular disease, a protective subset of vascular macrophages expressing the C-type lectin receptor CLEC4A2, a molecule which fosters "good" macrophage behavior within the vessel wall.

11 Jan 2022

Engineering higher affinity SARS-CoV-2 antibodies

A new study describes the potential of engineered neutralizing antibodies that have a high affinity for the binding epitopes.

11 Jan 2022

Study opens up prospects for using virotherapy to treat central nervous system tumors

In a study conducted at the University of São Paulo's Human Genome and Stem Cell Research Center (HUG-CELL) in Brazil, serial systemic injections of zika virus into mice with brain tumors destroyed the cancer without causing neurological damage or injuring other organs, and increased the animals' survival rate.

11 Jan 2022

Novel mechanisms controlling tertiary lymphoid structure formation in tumors revealed

Tertiary lymphoid structures are formations that occur outside of the lymphatic system. They contain immune cells and are similar in structure and function to lymph nodes and other lymphoid structures.

11 Jan 2022

Phase 1 clinical trial shows the safety, feasibility of CAR-M cell therapy for solid tumors

Preliminary findings from Penn Medicine in an ongoing first-in-human clinical trial examining the safety, tolerability and feasibility of chimeric antigen receptor macrophage (CAR-M) has helped to establish the viability of this innovative immunotherapy, which advances the trailblazing scientific discovery of CAR T cell therapy- also pioneered at Penn- for solid cancer tumors and offers a promising new strategy in the fight against cancer.

11 Jan 2022

COVID-19 symptoms found to vary in different immune contexts

In a new study, researchers studied the kinetics of host response to SARS-CoV-2 infection in a Syrian hamster model, tracking disease pathology, viral loads, antibody responses, and inflammatory cytokine production in multiple organs.

11 Jan 2022

Maternal transfer of healthier gut bacteria helps neonates to resist biliary atresia

Biliary atresia is a rare disease that occurs when a delicate tree-like set of ducts that carry bile from the liver to the intestine becomes scarred and blocked. While some treatments can slow the damage, most children who develop biliary atresia will die without a liver transplant.

10 Jan 2022

Researchers identify gene expression signatures linked to suicide risk

Is risk of suicide in our genes? Findings of an international scientific team led by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, suggest that gene expression studies could offer insights into the underlying causes of suicide, a highly complex public health problem that takes the lives of more than 800,000 people each year worldwide.

10 Jan 2022

NCCN publishes new guidelines for managing patients with Graft-Versus-Host Disease

The National Comprehensive Cancer Network today announced the publication of new NCCN Guidelines for Patients: Graft-Versus-Host Disease (GVHD).

10 Jan 2022

Scientists unravel how blood cells mount the first line of defense against viruses

Scientists have just slotted into place a big piece of the puzzle that explains how our blood cells mount their first line of defense against viruses.

10 Jan 2022

Immune System News and Research

Nanovaccines and their immunomodulatory effect against human viruses

Moffitt experts provide insight on the role of B cell immunity in endometrial cancer

Lack of evidence cross-reactive adaptive immune response is mechanism underlying COVID vaccine-induced myocarditis

Study finds evidence for increased activity of the brain’s immune system long before dementia onset

Living alone, serial break-ups may raise the levels of inflammatory markers in men

Regrowing knee cartilage can be a promising hop toward healing joints in humans

UCLA-led researchers improve method that was designed to kill HIV-infected cells

UCLA study provides new insights into molecular 'crosstalk' in pancreas cancer cells

A common cold may boost the immune system against COVID-19

New technique could allow more diseases to be safely treated by nanomedicine

Study finds a subset of vascular macrophages to be powerful ally in the fight against atherosclerosis

Engineering higher affinity SARS-CoV-2 antibodies

Study opens up prospects for using virotherapy to treat central nervous system tumors

Novel mechanisms controlling tertiary lymphoid structure formation in tumors revealed

Phase 1 clinical trial shows the safety, feasibility of CAR-M cell therapy for solid tumors

COVID-19 symptoms found to vary in different immune contexts

Maternal transfer of healthier gut bacteria helps neonates to resist biliary atresia

Researchers identify gene expression signatures linked to suicide risk

NCCN publishes new guidelines for managing patients with Graft-Versus-Host Disease

Scientists unravel how blood cells mount the first line of defense against viruses

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