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Dietary sugar has negative impact on health independent of obesity

Sugar-rich diets have a negative impact on health independent of obesity reports a new study led by the MRC London Institute of Medical Sciences, UK.

19 Mar 2020

Targeting PI3Kβ alone and with combination therapy in PTEN-deficient tumors

The cover for issue 11 of Oncotarget features Figure 6, "Effects of AZD8186 in combination with anti-PD1 on syngeneic models," by Owusu-Brackett, et al.

18 Mar 2020

Immune mechanism in the brain appears to play key role in the development of Alzheimer's

An immune reaction in the brain seems to play a major role in the development of Alzheimer's disease. In a way, it "adds fuel to the fire" and apparently causes an inflammation that, in a sense, keeps kindling itself. The study has now been published in the journal Cell Reports.

18 Mar 2020

High iron levels in lung increase severity of asthma

A new study published in the European Respiratory Journal in March 2020 reports that the accumulation of iron in the cells of the lung exacerbates asthma symptoms and reduces lung function.

17 Mar 2020

Engineered botox more effective

A new study reports on an engineered botulinum neurotoxin (botox) that is more effective as well as safer to use in various medical procedures. The study was published in March 2020 in the open-access journal PLOS Biology.

17 Mar 2020

Scientists develop single-step method to produce water-soluble fullerene compounds for medicine

Scientists from the Skoltech Center for Energy Science and Technology and the Institute for Problems of Chemical Physics of Russian Academy of Sciences in collaboration with researchers from the Catholic University of Leuven developed a single-step method to obtain water-soluble fullerene compounds with remarkable biological properties, such as the ability to effectively suppress the human immunodeficiency virus

17 Mar 2020

New understanding of signaling molecule interleukin-2 can guide drug discovery efforts

The signaling molecule interleukin-2 (IL-2) has long been known to have powerful effects on the immune system, but efforts to harness it for therapeutic purposes have been hampered by serious side effects.

17 Mar 2020

Scientists use artificial intelligence to create new proteins unseen in nature

Researchers have presented a artificial intelligence method for developing new proteins that have never been seen in nature.

17 Mar 2020

Antioxidant treatment in acute ischemic stroke could delay onset of clinically overt dementia

Currently we are facing a dementia epidemic, with estimations showing that by 2050 approximately 131 million people will be affected.

17 Mar 2020

Beijing Tide Pharmaceutical and Insilico Medicine announce cancer drug discovery collaboration

Beijing Tide Pharmaceutical Co., Ltd., a subsidiary of Sino Biopharmaceutical Limited, and Insilico Medicine, an artificial intelligence company developing end-to-end drug discovery pipelines, announced today that they are entering a collaboration, applying artificial intelligence technology to drug discovery, to jointly accelerate the process for multiple types of cancer treatment.

16 Mar 2020

Scientists engineer silkworms to produce different variants of adhesion molecules

Silkworms are useful for more than just making strong and absorbent strings of silky thread for the textiles industry.

16 Mar 2020

Breast milk may help protect preemies from developing sepsis

A component of breast milk may help protect premature babies from developing sepsis, a fast-moving, life-threatening condition triggered by infection.

16 Mar 2020

Trial of cancer drug OxaliTex promises lower toxicity and more robust action

Preclinical trials indicate that a drug candidate called OxaliTex can stop the growth of cancer cells completely. OxaliTex appears to be more potent than many other common chemotherapy drugs, with less toxicity and less rapidly counteracted by mechanisms of drug resistance. The study was reported in the journal Proceedings of the National Academy of Sciences in March 2020.

16 Mar 2020

Alzheimer's and its helper protein

It is commonly observed that the brain in patients with Alzheimer's disease (AD) often contains fibrils of tau protein, which build up within the brain neurons to interrupt proper communication between them. However, it is far from clear what these deposits mean and how they form.

15 Mar 2020

UC Riverside biochemist and Atomwise form new joint venture

Over the past few years, biochemist John Jefferson Perry at the University of California, Riverside, has collaborated on a number of projects with Atomwise Inc., a company that uses artificial intelligence, or AI, for drug discovery.

13 Mar 2020

Blood stem cells conserve epigenetic memory of previous infections to boost immunity

These findings should have a significant impact on future vaccination strategies and pave the way for new treatments of an underperforming or over-reacting immune system. The results of this research are published in Cell Stem Cell on March 12, 2020.

13 Mar 2020

NCAM2 protein is a vital factor in the formation of cerebral cortex, neuronal morphogenesis

The molecule NCAM2, a glycoprotein from the superfamily of immunoglobulins, is a vital factor in the formation of the cerebral cortex, neuronal morphogenesis and formation of neuronal circuits in the brain, as stated in the new study published in the journal Cerebral Cortex.

13 Mar 2020

Single-drug therapy can attack several cellular targets using different modes of action

Clinicians combat the drug resistances of some cancer types by using a combination of different drugs. To make this approach more effective, chemists have designed a chemical conjugate that can simultaneously attack several cellular targets using different modes of action.

13 Mar 2020

Prize-winning research offers a promising approach to improve regenerative medicine

Joana Neves is the 2019 grand prize winner of the Sartorius & Science Prize for Regenerative Medicine & Cell Therapy, for work that offers a promising approach to improve the outcome of regenerative stem cell-based therapies aimed at delaying age-related degenerative diseases.

12 Mar 2020

Protective brain-cell housekeeping mechanism may also be involved in regulating sleep

An important biological mechanism that is thought to protect brain cells from neurodegenerative diseases such as Alzheimer's and Parkinson's may also be involved in regulating sleep, according to new research from the Perelman School of Medicine at the University of Pennsylvania.

12 Mar 2020

Molecule News and Research

Dietary sugar has negative impact on health independent of obesity

Targeting PI3Kβ alone and with combination therapy in PTEN-deficient tumors

Immune mechanism in the brain appears to play key role in the development of Alzheimer's

High iron levels in lung increase severity of asthma

Engineered botox more effective

Scientists develop single-step method to produce water-soluble fullerene compounds for medicine

New understanding of signaling molecule interleukin-2 can guide drug discovery efforts

Scientists use artificial intelligence to create new proteins unseen in nature

Antioxidant treatment in acute ischemic stroke could delay onset of clinically overt dementia

Beijing Tide Pharmaceutical and Insilico Medicine announce cancer drug discovery collaboration

Scientists engineer silkworms to produce different variants of adhesion molecules

Breast milk may help protect preemies from developing sepsis

Trial of cancer drug OxaliTex promises lower toxicity and more robust action

Alzheimer's and its helper protein

UC Riverside biochemist and Atomwise form new joint venture

Blood stem cells conserve epigenetic memory of previous infections to boost immunity

NCAM2 protein is a vital factor in the formation of cerebral cortex, neuronal morphogenesis

Single-drug therapy can attack several cellular targets using different modes of action

Prize-winning research offers a promising approach to improve regenerative medicine

Protective brain-cell housekeeping mechanism may also be involved in regulating sleep

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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