Clinical Trial News and Research

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New technology predicts effectiveness of chemotherapy after one treatment

While early detection of breast cancer is critical, early prediction of how well the neoadjuvant chemotherapy treatment before surgery is working also may provide a window of opportunity when treatment could be altered and have a big impact on the patient's quality of life.

4 Jun 2021

Henry Ford Hospital cardiologists are first in the U.S. to implant circulatory support device

Cardiologists at Henry Ford Hospital are first in the U.S. and second in the world to implant a circulatory support device that is being investigated in a clinical trial for patients hospitalized with acute decompensated heart failure (ADHF) and worsening kidney function, a condition known as cardiorenal syndrome.

4 Jun 2021

Study: Diet can influence the breast microbiome and alter breast cancer tumors

When people think of microbiome, they typically think about the gut, but there's also a breast microbiome, and the role it plays in breast health and breast cancer isn't thoroughly understood. A microbiome is the collection of microorganisms that live in a particular environment in the body.

4 Jun 2021

UC San Diego Health offers new immunotherapy treatment for multiple myeloma following FDA approval

Following the Food and Drug Administration's approval, UC San Diego Health is the first designated medical center in San Diego certified to offer a new immunotherapy treatment of multiple myeloma outside of a clinical trial.

3 Jun 2021

Immunotherapy after surgery offers recurrence-free survival advantage for patients with high-risk melanoma

Patients with high-risk melanoma who had a course of pembrolizumab after their surgery had a longer time before their disease recurred than patients who got either ipilimumab or high-dose interferon after surgery.

3 Jun 2021

Heterologous AstraZeneca and Pfizer vaccines induce strong immune response and T cell reactivity against multiple SARS-CoV-2 variants

Researchers from Germany recently analyzed a cohort of 26 individuals in the age range of 25 to 46 (median 30.5) years who had received a ChAdOx1 nCoV-19 prime vaccine followed by a BNT162b2 boost vaccine after a 56-day interval due to changing vaccine recommendations in Germany. There were 16 females and 10 males in the cohort, and they were assessed for immune responses, reactogenicity, and T cell reactivity. This study is published on the medRxiv* preprint server.

3 Jun 2021

Study: Some Type 2 diabetes patients can benefit from bone marrow stem cell transplants

Type 2 diabetes patients who are not overweight and who have had the disorder for less than a decade can benefit from stromal stem cells transplanted from their own bone marrow, according to a study published today in STEM CELLS Translational Medicine.

3 Jun 2021

Centivax and US Naval Medical Research Center to begin Phase I clinical trial of antibody therapeutics

Centivax Inc. announced today that it has entered into a strategic partnership with the U.S. Naval Medical Research Center (NMRC) for Phase I clinical development of Centi-B9, Centivax's SARS-CoV-2 broad-spectrum injectable antibody therapeutic and prophylactic.

3 Jun 2021

Antibiotics provide no benefit for patients with idiopathic pulmonary fibrosis, study finds

Doctors have hoped that antibiotics could benefit patients with chronic lung diseases, but a new study has found no benefit for patients with life-threatening idiopathic pulmonary fibrosis in preventing hospitalization or death.

2 Jun 2021

Cmed Technology Adds More Capabilities to its Encapsia Platform and Reports Increased Demand for Use in Decentralized Trials (DCT)

Innovative technology for clinical trials is now, more than ever, necessary to deliver decentralized trials (DCT) and enable design of hybrid protocols that support trial continuity and patient-centricity.

2 Jun 2021

Could 3D printed swabs be used to collect COVID-19 test samples?

Researchers have evaluated 3D printed sample collection swabs made in-house and found them to be a reliable alternative to commercial swabs.

2 Jun 2021

NIH launches first-in-human, Phase 1 trial assessing investigational nanoparticle influenza vaccine

A first-in-human, Phase 1 trial assessing the safety and immunogenicity of an investigational nanoparticle influenza vaccine designed to provide long-lasting protection against multiple flu virus strains has begun at the National Institutes of Health Clinical Center in Bethesda, Maryland.

1 Jun 2021

Small chip inserted under the skin may help predict the likelihood of recurrent stroke

For patients who have experienced certain common types of stroke, a small chip inserted under the skin may help physicians predict their likelihood of experiencing a second stroke, and therefore their likelihood of benefiting from preventive therapy.

1 Jun 2021

Implantable device more effective at detecting atrial fibrillation than standard of care

A clinical trial examining the efficacy of two devices to monitor and detect atrial fibrillation (AF), or an irregular heartbeat, in ischemic stroke patients--one an implantable device that monitors over 12 months, the other an external device that monitors over a 30-day period--found the implantable device is more than three times more effective in detecting AF, and both are a significant improvement over the current standard of care in Alberta, Canada.

1 Jun 2021

New device can increase penile length and preserve erectile function in men after prostatectomy

A new type of penile traction therapy (PTT) device can increase penile length and preserve erectile function in men who have undergone prostate cancer surgery (prostatectomy), reports a clinical trial in The Journal of Urology®, Official Journal of the American Urological Association (AUA).

1 Jun 2021

Scientists explain possible causes of anaphylaxis following mRNA COVID-19 vaccination

New research from a team of scientists at the Centre for Research in Molecular Modeling, Department of Chemistry and Biochemistry, Concordia University in Canada, has aimed to determine the potential causes of anaphylaxis or allergic reactions reported in some individuals after receiving COVID-19 vaccines, including the mRNA vaccines by Pfizer-BioNTech and Moderna.

1 Jun 2021

NIH starts Phase 1/2 clinical trial evaluating mixed COVID-19 vaccine schedules

The National Institutes of Health has started a Phase 1/2 clinical trial in which adult volunteers who have been fully vaccinated against COVID-19 will receive booster doses of different COVID-19 vaccines to determine the safety and immunogenicity of mixed boosted regimens.

1 Jun 2021

Researchers receive $5 million NIH grant to reduce childhood obesity disparities

A research team led by the University of Minnesota Medical School has been awarded a $5 million grant from the National Institute of Health to conduct a clinical trial that hopes to identify the most effective approach to reduce racial and ethnic disparities in childhood obesity.

1 Jun 2021

Antibody cocktail effectively inhibits SARS-CoV-2 in the rhesus macaque model

Researchers from the US tested the prophylactic potential of a combination of 2 mAbs administered 3 or 75 days before respiratory challenge in rhesus macaques. They used the rhesus macaque model to test the added benefit of combinatory parenteral administration of 2 high-affinity anti-SARS-CoV-2 mAbs - C144-LS and C135-LS. These mAbs were developed to neutralize the virus and tweaked to improve their pharmacokinetics.

1 Jun 2021

FDA approves investigational monoclonal antibody therapy sotrovimab for COVID-19

The U.S. Food and Drug Administration (FDA) has given the green light on the investigational monoclonal antibody therapy, sotrovimab, as a coronavirus disease (COVID-19) treatment.

1 Jun 2021

Clinical Trial News and Research

New technology predicts effectiveness of chemotherapy after one treatment

Henry Ford Hospital cardiologists are first in the U.S. to implant circulatory support device

Study: Diet can influence the breast microbiome and alter breast cancer tumors

UC San Diego Health offers new immunotherapy treatment for multiple myeloma following FDA approval

Immunotherapy after surgery offers recurrence-free survival advantage for patients with high-risk melanoma

Heterologous AstraZeneca and Pfizer vaccines induce strong immune response and T cell reactivity against multiple SARS-CoV-2 variants

Study: Some Type 2 diabetes patients can benefit from bone marrow stem cell transplants

Centivax and US Naval Medical Research Center to begin Phase I clinical trial of antibody therapeutics

Antibiotics provide no benefit for patients with idiopathic pulmonary fibrosis, study finds

Cmed Technology Adds More Capabilities to its Encapsia Platform and Reports Increased Demand for Use in Decentralized Trials (DCT)

Could 3D printed swabs be used to collect COVID-19 test samples?

NIH launches first-in-human, Phase 1 trial assessing investigational nanoparticle influenza vaccine

Small chip inserted under the skin may help predict the likelihood of recurrent stroke

Implantable device more effective at detecting atrial fibrillation than standard of care

New device can increase penile length and preserve erectile function in men after prostatectomy

Scientists explain possible causes of anaphylaxis following mRNA COVID-19 vaccination

NIH starts Phase 1/2 clinical trial evaluating mixed COVID-19 vaccine schedules

Researchers receive $5 million NIH grant to reduce childhood obesity disparities

Antibody cocktail effectively inhibits SARS-CoV-2 in the rhesus macaque model

FDA approves investigational monoclonal antibody therapy sotrovimab for COVID-19

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