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Combining ezetimibe and bempedoic acid effectively lowers cholesterol in statin-intolerant patients

A simulation study analyzing over two million German outpatients found that combining ezetimibe and bempedoic acid effectively reduces LDL cholesterol in statin-intolerant patients with hypercholesterolemia.

7 Jan 2024

Stapled lipopeptides show promise as broad-spectrum antiviral agents

Compounds that obstruct the "landing gear" of a range of harmful viruses can successfully protect against infection by the virus that causes COVID-19, a study published today and led by Dana-Farber Cancer Institute scientists shows.

5 Jan 2024

IKAROS: Unlocking the secrets of the immune system's key player

In a scientific breakthrough that aids our understanding of the internal wiring of immune cells, researchers at Monash University in Australia have cracked the code behind IKAROS, an essential protein for immune cell development and protection against pathogens and cancer.

5 Jan 2024

Breakthrough drug halts lung cancer and brain metastases

D'Or Institute for Research and Education (IDOR) played an important role in the phase III LIBRETTO-431 multicenter study, which evaluated the efficacy and safety of selpercatinib compared to control treatment, which consisted of platinum-based chemotherapy associated or not with pembrolizumab (immune checkpoint inhibitor) in non-small cell lung cancer (NSCLC).

5 Jan 2024

Study: Two-thirds of babies with sickle cell disease are born to mothers living in disadvantaged areas

As if starting life with a potentially disabling genetic blood disease wasn't enough, a study shows that almost two-thirds of babies born with sickle cell disease are born to mothers who live in disadvantaged areas.

4 Jan 2024

40-year timeline of HIV: Testing assays, global burden, prevalence, treatment, and challenges

Announcing a new article publication for Zoonoses journal. More than 77 million individuals have been infected with the human immunodeficiency virus (HIV) and approximately 37.6 million people are living with HIV infection.

4 Jan 2024

GLP-1R agonist liraglutide rapidly improves insulin sensitivity in pre-diabetics, independent of weight loss

A new study published in the journal Diabetes demonstrates that a glucagon-like peptide-1 receptor (GLP-1R) agonist, a member of a class of medication used to treat Type 2 diabetes and obesity, can lead to a rapid improvement in insulin sensitivity.

4 Jan 2024

Scientists unearth dual-action weapons against deadly tuberculosis

A research team has detected various substances that have a dual effect against tuberculosis: They make the bacteria causing the disease less pathogenic for human immune cells and boost the activity of conventional antibiotics / publication in ‘Cell Chemical Biology’.

4 Jan 2024

New study highlights the work of biobank at the Colorado Center for Personalized Medicine

A new peer-reviewed study in the American Journal of Human Genetics highlights the work of the biobank at the Colorado Center for Personalized Medicine (CCPM), a world-class site for precision medicine in research and clinical care created in partnership with the University of Colorado Anschutz Medical Campus and UCHealth.

4 Jan 2024

High-resolution map of the neuroblastoma immune landscape points to new target for immunotherapy

A detailed 'atlas' of neuroblastoma tumors points to a new target for immunotherapy. Scientists from the Princess Máxima Center for Pediatric Oncology in the Netherlands mapped this childhood tumor at the level of individual cancer and immune cells.

4 Jan 2024

Pre-pregnancy stress raises blood sugar during pregnancy, study finds

A new Journal of the Endocrine Society study among women attending a fertility center found that those with more stress before pregnancy had higher blood sugar levels during pregnancy, which is a sign of weaker cardiovascular health.

4 Jan 2024

Maternal stress during preconception associated with higher blood glucose levels, study finds

Stress during pregnancy is known to influence health outcomes, but a new study from Mass General Brigham researchers suggests that stress levels before pregnancy are also important to evaluate.

4 Jan 2024

Combination therapy of dapagliflozin and semaglutide shows superior efficacy in type 2 diabetes management

Study demonstrates that combining dapagliflozin and semaglutide significantly improves glycemic control and other health parameters in type 2 diabetes patients, outperforming dapagliflozin alone.

3 Jan 2024

Research could offer a new approach to treating malnourished, stunted kids

Millions of children in under-resourced parts of the world suffer from malnutrition and, consequently, stunted growth.

3 Jan 2024

New study demystifies clinicians' decision-making process for drug-drug interactions

Drug-drug interactions causing adverse effects are common and can cause significant patient harm and even death.

3 Jan 2024

Eastern equine encephalitis virus study uncovers decoy molecule that protects against deadly brain infection

An atomic-level investigation of how Eastern equine encephalitis virus binds to a key receptor and gets inside of cells also has enabled the discovery of a decoy molecule that protects against the potentially deadly brain infection, in mice.

3 Jan 2024

New brain imaging technique sheds light on invisible mTBIs

Researchers have created a new brain imaging method that allows mild traumatic brain injuries (mTBIs) to be diagnosed, even when existing imaging techniques like magnetic resonance imaging (MRI) don't show any structural abnormalities.

3 Jan 2024

Mount Sinai study provides a mechanistic explanation for variations in individual responses to drugs

Mount Sinai researchers have shown for the first time that a person's beliefs related to drugs can influence their own brain activity and behavioral responses in a way comparable to the dose-dependent effects of pharmacology.

3 Jan 2024

Yale scientists identify drug target that may alleviate joint degeneration in osteoarthritis

Yale researchers have identified a drug target that may alleviate joint degeneration associated with osteoarthritis, a debilitating condition that afflicts as many as 30 million people in the United States alone, which they report on Jan. 3 in the journal Nature.

3 Jan 2024

$4.9 million grant awarded to build EndO-trial consortium for improving the lives of Crohn's patients

Cleveland Clinic and the University of Western Ontario have been awarded a $4.9 million grant from Helmsley Charitable Trust to build a consortium to develop clinical trial outcome tools for patients with Crohn's disease and permanent ileostomy.

3 Jan 2024

Drugs News and Research

Combining ezetimibe and bempedoic acid effectively lowers cholesterol in statin-intolerant patients

Stapled lipopeptides show promise as broad-spectrum antiviral agents

IKAROS: Unlocking the secrets of the immune system's key player

Breakthrough drug halts lung cancer and brain metastases

Study: Two-thirds of babies with sickle cell disease are born to mothers living in disadvantaged areas

40-year timeline of HIV: Testing assays, global burden, prevalence, treatment, and challenges

GLP-1R agonist liraglutide rapidly improves insulin sensitivity in pre-diabetics, independent of weight loss

Scientists unearth dual-action weapons against deadly tuberculosis

New study highlights the work of biobank at the Colorado Center for Personalized Medicine

High-resolution map of the neuroblastoma immune landscape points to new target for immunotherapy

Pre-pregnancy stress raises blood sugar during pregnancy, study finds

Maternal stress during preconception associated with higher blood glucose levels, study finds

Combination therapy of dapagliflozin and semaglutide shows superior efficacy in type 2 diabetes management

Research could offer a new approach to treating malnourished, stunted kids

New study demystifies clinicians' decision-making process for drug-drug interactions

Eastern equine encephalitis virus study uncovers decoy molecule that protects against deadly brain infection

New brain imaging technique sheds light on invisible mTBIs

Mount Sinai study provides a mechanistic explanation for variations in individual responses to drugs

Yale scientists identify drug target that may alleviate joint degeneration in osteoarthritis

$4.9 million grant awarded to build EndO-trial consortium for improving the lives of Crohn's patients

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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