Nephrology News and Research

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Nephrology is a branch of internal medicine and pediatrics dealing with the study of the function and diseases of the kidney.

Glimmer of hope for imatinib-resistant GIST

The monoclonal antibody SR1 can significantly inhibit gastrointestinal stromal tumor cell growth, report researchers in the Proceedings of the National Academy of Sciences.

7 Feb 2013

Tumor suppressor mutant may predict poor outcome in breast cancer

An oncogenic variant of the Krüppel-like family 6 tumor suppressor gene appears to play a role in driving breast cancer metastasis and may be a prognostic marker for poor patient outcome, report researchers.

6 Feb 2013

‘Elephant in the room’ adds to rectal surgery costs

Anastomotic leakage occurs after one in 10 anterior resection procedures and costs English hospitals up to £ 3.5 milion per year, research shows.

6 Feb 2013

Donor liver quality: an interview with Dr Eric Orman

Liver transplantation is a surgical procedure in which a liver (or part of a liver) is removed from a donor and placed into a recipient. Although some transplants use a portion of the liver of living donors, the vast majority of donors are deceased.

6 Feb 2013

Patients undergoing major vascular surgery procedures are at increased risk of stroke

Patients undergoing major vascular surgery procedures are at increased risk of stroke, leading to a high mortality rate and prolonged hospitalization, according to a study in the February issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

6 Feb 2013

Viracor-IBT Laboratories signs definitive agreement to purchase assets of Cylex

Viracor-IBT Laboratories, Inc. announced today that it has signed a definitive agreement to purchase the assets of Cylex, Inc., a global life sciences company focused on the development, manufacturing and commercialization of in vitro diagnostic products intended to illuminate immunity in the area of transplant medicine.

5 Feb 2013

Second trimester HG demands vigilance

Women who experience hyperemesis gravidarum during the second trimester have an increased risk for certain birth complications associated with placental abruption, study results show.

5 Feb 2013

Seven factors rule out CT for children with abdominal injury

Research shows that children presenting with abdominal injury at an emergency department who lack seven key factors are extremely unlikely to have an injury requiring acute intervention and therefore do not require computed tomography scanning.

5 Feb 2013

Vitamin C supplements increase risk of kidney stones in men

New research from Karolinska Institutet in Sweden shows that men who take vitamin C supplements regularly run a higher risk of developing kidney stones. The study, which is published in the scientific periodical JAMA Internal Medicine, did not however observe an increased risk between kidney stones and multivitamins - which contain lower concentrations of vitamin C.

5 Feb 2013

Scientists identify specific cellular events that appear key to lupus

A team led by scientists at The Scripps Research Institute (TSRI) has identified specific cellular events that appear key to lupus, a debilitating autoimmune disease that afflicts tens of millions of people worldwide. The findings suggest that blocking this pathway in lupus-triggering cells could be a potent weapon against the disease.

5 Feb 2013

USPTO issues patent to KAHR-101 for treatment of cancers, arthritis and MS

Hadasit Bio-Holdings Ltd., a publicly traded portfolio of biotech companies, based on intellectual property developed and owned by Hadassah University Hospital, Israel's foremost medical research center, today announced that its portfolio company, KAHR Medical Ltd., was granted a U.S. patent approval (U.S. Patent No. 8329657).

5 Feb 2013

Interferon retreatment warning in HCV

Hepatitis C virus patients who do not respond to interferon should not receive further treatment with the drug, say the authors of a new Cochrane review.

4 Feb 2013

Epidemiology model supports 20:80 transmission rule in HCV

A new hepatitis C virus transmission model combining genetic and epidemiologic data reveals that the majority of transmission of the virus is by a minority of intravenous drug users.

4 Feb 2013

Operative drainage after pancreatic resection ‘should be abandoned’

Routine prophylactic drainage offers no benefits to patients undergoing pancreatic resection, say researchers.

4 Feb 2013

African-Americans without private health insurance less likely to receive kidney transplants

African-Americans and individuals without private health insurance are less likely than others to receive a kidney transplant before requiring dialysis, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN).

1 Feb 2013

Delaware District Court rules in favor of Pfizer in RAPAMUNE patent case

Pfizer Inc. said today that the United States District Court for the District of Delaware ruled that Pfizer's patent covering a method for using sirolimus, the active ingredient in RAPAMUNE®, for the inhibition of organ transplant rejection is valid and infringed.

31 Jan 2013

Gene variant boosts ulcer susceptibility in NSAID users

A single nucleotide polymorphism in the cytochrome P450 2C gene cluster influences the risk for peptic ulcer disease in people taking non-steroidal anti-inflammatory drugs, a study reveals.

31 Jan 2013

Hypertensive pregnancies need rigorous follow up

Women who have hypertensive complications during pregnancy are at increased risk for developing chronic kidney disease and end-stage renal disease, shows a study in the Canadian Medical Association Journal.

31 Jan 2013

Waist size trumps BMI as Barrett’s esophagus risk factor

Researchers have found that waist circumference independently predicts the risk for Barrett’s esophagus, leading them to dismiss a previously reported association between body mass index and the disease.

31 Jan 2013

Performing angiography and cardiac surgery on the same day increases risk of acute kidney injury

Performing heart surgery on the same day as angiography is now confirmed as a risk factor for acute kidney injury (AKI), and hospital policy limiting the practice for elective cardiac surgery has significantly reduced the rate of AKI, according to a study published in the February 2013 issue of The Annals of Thoracic Surgery.

31 Jan 2013