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Researchers reveal important factor behind cancer therapy resistance and a way to counter it

Why doesn't every cancer patient respond to immunotherapy? That's the question that researcher Daniel Peeper is looking to answer.

9 Jun 2022

Research reveals how highly proliferative leukemia cells turn into normal harmless ones

A new research describes how highly proliferative leukemia cells end up becoming normal cells that no longer multiply, by changing the chemical modifications -the so-called epigenetics- of a type of its genetic material: the messenger RNA.

9 Jun 2022

USA–Japan Workshop participants present cutting-edge research on biomarkers for early detection of cancer

Successful treatment of cancer frequently depends on early detection. However, many cancers are detected late, often after metastasizing to other sites.

9 Jun 2022

Researchers demonstrate the double advantage of killer T-cells used in cancer immunotherapy

To grow, tumors rely on a specific structure, the tumor stroma. This includes blood vessels, which provide the nutrients necessary for the multiplication of diseased cells, and of lymphatic vessels, through which they migrate to metastasize.

9 Jun 2022

The presence of residual SARS-CoV-2 antigens in post-convalescent tissues

Researchers investigated the residual SARS-CoV-2 antigen found in long COVID-19 patients.

9 Jun 2022

Cognitive impairment and function in SARS-CoV-2 positive patients

Researchers assessed the association between post-acute COVID-19 cognitive impairment and kynurenine pathway activation.

9 Jun 2022

Synthetic IL-9 receptor allows T cells to fight cancer without the need for chemo or radiation

Before a patient can undergo T cell therapy designed to target cancerous tumors, the patient's entire immune system must be destroyed with chemotherapy or radiation. The toxic side effects are well known, including nausea, extreme fatigue and hair loss.

8 Jun 2022

SARS-CoV-2 ORF8 protein binds to dendritic cells and induces a hyper-inflammatory cytokine storm

In a recent study posted to the bioRxiv* pre-print server, researchers examined how the interaction of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) open reading frame 8 (ORF8) protein with host dendritic cells (DCs) induced cytokine storm.

8 Jun 2022

Oral administration of rapamycin increases β-amyloid buildup in Alzheimer's disease mouse model

Researchers from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) have found that oral administration of rapamycin to an Alzheimer's disease mouse model causes an increase in beta (β)-amyloid protein plaques. β-amyloid buildup is a hallmark of Alzheimer's disease.

7 Jun 2022

New microbubble-assisted ultrasound-guided immunotherapy helps improve anti-tumor immunity

Researchers at UT Southwestern have developed a first-of-its-kind ultrasound-guided cancer immunotherapy platform that delivers immune-stimulating agents to cells for the development of systemic anti-tumor immunity.

7 Jun 2022

New FR-targeting, micropinocytosis-mediated bioconjugate attacks K-Ras mutant pancreatic cancer

Often undetected until it has progressed to an advanced stage, pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer.

6 Jun 2022

Phase separation discovery could lead to new interventions to regulate immune activity

Protein complexes that play a critical role in launching an immune response assemble in droplets that form within the liquid environment in cells much like oil droplets in water, UT Southwestern scientists report in a new study.

6 Jun 2022

Color-changing mouse model aids in better visualization of internal physiology

Biomedical and genetic engineers at Duke University and the Albert Einstein College of Medicine have developed a process to change the color of a mouse's tissue in imaging to better visualize its internal physiology.

6 Jun 2022

Drug combination yields highest response and longest survival rates for patients with pancreatic NETs

Very few treatment options are available to patients with advanced pancreatic neuroendocrine tumors (NETs), but researchers at the Yale Cancer Center and Yale New Haven Health's Smilow Cancer Hospital found that patients treated with a combination of capecitabine and temozolomide had longer progression-free survival rates than those treated with temozolomide alone.

6 Jun 2022

She’s 31, has stage 4 kidney cancer — and talked openly about it in a job interview

Katie Coleman stood face-to-face with a choice no job seeker should ever have to make. She could tell her prospective employer she had stage 4 kidney cancer, the most life-threatening stage of all.

6 Jun 2022

Trial of peptide-centered SARS-CoV-2 T-cell activator in B-cell deficient individuals

A recent phase 1/2 study under review at the Nature Portfolio journal and posted to the Research Square* preprint server demonstrated that a peptide-centered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) T-cell activator, CoVac-1, was efficient in B-cell deficient people.

6 Jun 2022

Using DNA droplets for early disease detection

Aqueous droplet formation by liquid-liquid phase separation (or coacervation) in macromolecules is a hot topic in life sciences research.

3 Jun 2022

Exploring the effectiveness of various treatments in people with axial spondyloarthritis

axSpA is a chronic inflammatory rheumatic disease that mainly affects the spine and sacroiliac joints. It can cause significant pain and disability.

3 Jun 2022

Study: Nearly 43% of patients with KRAS-mutated lung cancer respond to experimental drug adagrasib

Nearly 43% of patients with non-small cell lung cancer (NSCLC) whose lung cancers harbored a specific KRAS mutation responded to the experimental drug adagrasib, and the targeted agent also showed activity against lesions in the brain that metastasized from the lung tumors, according to results of a study led by Dana-Farber Cancer Institute investigators.

3 Jun 2022

New immunotherapy mechanism can block spontaneous breast carcinogenesis

Researchers have discovered the mechanism by which specific immune cells can block breast cancer development and even suppress a developed tumor.

3 Jun 2022

Tumor News and Research

Researchers reveal important factor behind cancer therapy resistance and a way to counter it

Research reveals how highly proliferative leukemia cells turn into normal harmless ones

USA–Japan Workshop participants present cutting-edge research on biomarkers for early detection of cancer

Researchers demonstrate the double advantage of killer T-cells used in cancer immunotherapy

The presence of residual SARS-CoV-2 antigens in post-convalescent tissues

Cognitive impairment and function in SARS-CoV-2 positive patients

Synthetic IL-9 receptor allows T cells to fight cancer without the need for chemo or radiation

SARS-CoV-2 ORF8 protein binds to dendritic cells and induces a hyper-inflammatory cytokine storm

Oral administration of rapamycin increases β-amyloid buildup in Alzheimer's disease mouse model

New microbubble-assisted ultrasound-guided immunotherapy helps improve anti-tumor immunity

New FR-targeting, micropinocytosis-mediated bioconjugate attacks K-Ras mutant pancreatic cancer

Phase separation discovery could lead to new interventions to regulate immune activity

Color-changing mouse model aids in better visualization of internal physiology

Drug combination yields highest response and longest survival rates for patients with pancreatic NETs

She’s 31, has stage 4 kidney cancer — and talked openly about it in a job interview

Trial of peptide-centered SARS-CoV-2 T-cell activator in B-cell deficient individuals

Using DNA droplets for early disease detection

Exploring the effectiveness of various treatments in people with axial spondyloarthritis

Study: Nearly 43% of patients with KRAS-mutated lung cancer respond to experimental drug adagrasib

New immunotherapy mechanism can block spontaneous breast carcinogenesis

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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