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Prostate cancer risk linked to high cholesterol

Italian Researchers say they have found what they believe to be the first direct link between high cholesterol levels and prostate cancer.

12 Apr 2006

Tough times ahead for NHS despite record investment

British Prime Minister Tony Blair yesterday met with the chief executives of sixteen Primary Care Trusts to discuss the financial crisis dogging the National Health Service (NHS).

12 Apr 2006

Study assesses formularies across Medicare drug plans

Medicare's new private stand-alone drug plans vary significantly - in terms of covered drugs, out-of-pocket costs for specific medications, and restrictions placed on the use of certain drugs - according to a new analysis released today by the Kaiser Family Foundation.

11 Apr 2006

Statins may be able to play a role in preventing or slowing heart valve disease

Research to be published in the April 18 issue of the Journal of the American College of Cardiology provides the first explanation of an active rather than passive process that leads to heart valve degeneration, furthering a Northwestern researcher's effort to lead a paradigm shift in the medical community's beliefs about the cause of valve disease.

11 Apr 2006

New insights into how anti-rejection drug daclizumab (Zenapax) helps MS patients

A research team led by the University of Cincinnati's Bibiana Bielekova, MD, report new insights into the role of the MS drug daclizumab (Zenapax) in the Proceedings of the National Academy of Sciences.

11 Apr 2006

Oral post-surgical complications following the administration of bisphosphonates given for osteopenia related to malignancy

The patient of a periodontist in private practice in New Orleans developed osteonecrosis of the jaw (ONJ), a condition that can cause severe, often irreversible and debilitating damage to the jaw, following periodontal surgical therapy.

11 Apr 2006

Benefit of chemotherapy in breast cancer depends on estrogen status of tumors

When it comes to chemotherapy treatment for women whose breast cancer has spread to their lymph nodes, the estrogen status of their tumors matters, says a team of researchers in the Journal of the American Medical Association.

11 Apr 2006

Stem cells can repair damaged spinal tissue and help restore function in rats with spinal cord injuries

Each year, some 11,000 Americans sustain spinal cord injury, most often in traffic accidents. Costs of the condition approach $10 billion per year.

11 Apr 2006

New model of p53 regulation has important implications for the development of anticancer drugs

Genetically engineered mice convinced scientists at the Salk Institute for Biological Studies that it was time to overhaul widely held beliefs about how a powerful tumor suppressor called p53 is controlled in cells. Their new model of p53 regulation has important implications for the development of anticancer drugs.

11 Apr 2006

U.S. watchdog says Xenical should be withdrawn

A consumer watchdog group in the U.S., Public Citizen, has petitioned the U.S. Food and Drug Administration (FDA) to withdraw the prescription diet drug Xenical (orlistat) from the market; the group also want the FDA to refuse approval for the weight-loss pill to be made widely available over the counter.

11 Apr 2006

Researchers determine factors that turn on protein production in bacteria

In the study, published in the journal Molecular Cell, researchers Sean Studer and Simpson Joseph in UCSD's Department of Chemistry and Biochemistry report how the messenger RNA instructions to make a protein are unfolded in a bacterial cell, so that they can be read by the cell's protein-making machinery.

11 Apr 2006

Single dose of stem cells produce robust behavioral recovery in animal models for stroke, cerebral palsy

A single dose of adult donor stem cells given to animals that have neurological damage similar to that experienced by adults with a stroke or newborns with cerebral palsy can significantly enhance recovery from these types of injuries, researchers say.

11 Apr 2006

St. John's wort and Echinacea increase activity of enzyme in the liver and intestine

St. John's wort and Echinacea, two widely-used herbal preparations, have been found to increase activity of a specific enzyme in the liver and intestine, an enzyme involved in the metabolization of roughly one in every four pharmaceutical drugs on the market today, reports a clinical pharmacologist at Indiana University School of Medicine.

11 Apr 2006

Scientists identify a new gene that causes the spread of cancer

Professor Philip Rudland, Dr Guozheng Wang and Dr Roger Barraclough from Liverpool University's Cancer and Polio Research Fund Laboratories have discovered an additional member of the S100 family of protein genes - S100P - that causes the spread of cancerous cells from an original tumour to other parts of the body.

11 Apr 2006

Losartan can prevent progression of Marfan syndrome

A commonly prescribed blood pressure medication may provide the first ray of hope in preventing potentially deadly complications of Marfan syndrome, a genetic disease that weakens the structural meshwork of blood vessels.

11 Apr 2006

Researchers unravel structure of important new drug target that could potentially treat SARS-infected patients

Mesecar said that the knowledge gained from this new atomic structure - the first-ever reported on this class of proteases - has the potential to go beyond the treatment of patients infected with the coronavirus that causes SARS.

11 Apr 2006

Colorimetric screening detects DNA, small molecules and proteins

Using the unusual color properties of gold at the nanoscale, scientists at Northwestern University have developed a "litmus test" for DNA and small molecule binding that eventually could be used by pharmaceutical companies to rapidly identify promising candidates for new anti-cancer drugs.

11 Apr 2006

Leptin may lead to new approaches for curbing appetite

Hot fudge sundaes and french fries aside, new research suggests obesity is due at least in part to an attraction between leptin, the hormone that signals the brain when to stop eating, and a protein more recently associated with heart disease.

11 Apr 2006

Guidelines for medication withdrawal

Although thousands of scientific papers evaluate and compare new and established drugs each year, providing evidence to help doctors prescribe safe and effective doses, almost no studies focus on when or how to stop these medications, even late in life.

11 Apr 2006

Biodegradable drug containing nano-particles effective in killing human breast tumors

Research studies, based at the University of Pennsylvania, demonstrate that biodegradable nano-particles containing two potent cancer-fighting drugs are effective in killing human breast tumors.

11 Apr 2006

Drugs News and Research

Prostate cancer risk linked to high cholesterol

Tough times ahead for NHS despite record investment

Study assesses formularies across Medicare drug plans

Statins may be able to play a role in preventing or slowing heart valve disease

New insights into how anti-rejection drug daclizumab (Zenapax) helps MS patients

Oral post-surgical complications following the administration of bisphosphonates given for osteopenia related to malignancy

Benefit of chemotherapy in breast cancer depends on estrogen status of tumors

Stem cells can repair damaged spinal tissue and help restore function in rats with spinal cord injuries

New model of p53 regulation has important implications for the development of anticancer drugs

U.S. watchdog says Xenical should be withdrawn

Researchers determine factors that turn on protein production in bacteria

Single dose of stem cells produce robust behavioral recovery in animal models for stroke, cerebral palsy

St. John's wort and Echinacea increase activity of enzyme in the liver and intestine

Scientists identify a new gene that causes the spread of cancer

Losartan can prevent progression of Marfan syndrome

Researchers unravel structure of important new drug target that could potentially treat SARS-infected patients

Colorimetric screening detects DNA, small molecules and proteins

Leptin may lead to new approaches for curbing appetite

Guidelines for medication withdrawal

Biodegradable drug containing nano-particles effective in killing human breast tumors

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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