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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Study explores role of APOBEC-mediated RNA editing in SARS-CoV-2 fitness

A new study investigated whether APOBEC proteins can directly edit the RNA sequence of SARS-CoV-2 to generate C-to-U mutations.

14 Apr 2022

Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

Researchers reviewed non-viral nano-vectors used for delivering the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated genome editing system.

14 Apr 2022

Single-dose vaccine delivers protection against cervical cancer-causing HPV comparable to 2 or 3-dose regimes

A recent report suggested that a single dose of the human papillomavirus (HPV) vaccination confers equivalent immunity to a two-dose schedule against cervical cancers caused by HPV.

14 Apr 2022

COVID-19 may affect a group of biochemical reactions called one-carbon metabolism

A new study addresses the relationship between SARS-CoV-2 to the metabolism of one-carbon molecules in the host, suggesting new therapeutic pathways.

13 Apr 2022

Dietary influences on long COVID in children

A new study discusses possible mechanisms of long COVID in children and how they might relate to their dietary intake of important vitamins and elements.

13 Apr 2022

Regulation of alternative splicing goes haywire in cells of a newly formed embryo

Alternative splicing is a fundamental biological process that allows cells to make many different types of mRNAs and proteins from a limited number of genes. For many animals, including humans, it is a feature that is essential for the development of complex cells such as muscles or neurons.

13 Apr 2022

Researchers identify certain gene regulation signatures in CAR T-resistant leukemia patients

Acute lymphoblastic leukemia (ALL) cells from patients whose cancers did not respond to CD19-targeted CAR T therapy had gene regulation signatures that could potentially facilitate treatment resistance, according to results presented at the AACR Annual Meeting 2022, held April 8-13.

13 Apr 2022

Bioprinting for bone repair enhanced with two growth factor encoding genes

Given enough time and energy, the body will heal, but when doctors or engineers intervene, the processes do not always proceed as planned because chemicals that control and facilitate the healing process are missing.

13 Apr 2022

New bioinformatics platform predicts optimal treatment combinations for cancer patients

Researchers at The University of Texas MD Anderson Cancer Center have developed a new bioinformatics platform that predicts optimal treatment combinations for a given group of patients based on co-occurring tumor alterations.

12 Apr 2022

Researchers discover new way to inhibit key mutated gene underlying tumor growth

CU Boulder researchers have discovered a new way to inhibit the most commonly mutated gene underlying human tumor growth, opening the door to new therapeutic strategies for cancer and a host of other diseases.

12 Apr 2022

Research using kidney organoids may lead to new targets to help prevent or treat CKD

To a certain extent, kidneys have the capacity to repair themselves after being injured, but a switch can occur from such intrinsic repair to incomplete repair that leads to irreversible damage and chronic kidney disease (CKD).

12 Apr 2022

Experimental tool can precisely pick out interactions between immune cell and target antigen

The human body has millions of unique B and T cells that roam the body, looking for microbial invaders. These immune cells' ability to recognize harmful microbes is critical to successfully fighting off infection.

12 Apr 2022

Novel Hendra virus variant detected in flying fox urine

Researchers reported on the detection of a novel Hendra virus variant of genotype 2 (HeV-g2) in the urine of grey-headed and black flying foxes in Australia.

12 Apr 2022

Scientists find critical role for Hippo signaling pathway in COVID-19 pathogenesis

A recent article posted to the bioRxiv* preprint server illustrated that the activation of the Hippo signaling pathway upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection aids the host antiviral response.

11 Apr 2022

Drugs targeting DNA damage response pathway show therapeutic potential against advanced solid tumors

Results from early-stage clinical trials show two drugs that target the DNA damage response (DDR) pathway in cancers - ATR inhibitor elimusertib and PARP inhibitor AZD5305 - are safe and clinically beneficial in treating patients with advanced solid tumors.

11 Apr 2022

Study finds molecular features responsible for the development of metastatic breast cancer

Susana Garcia-Recio, PhD, a research associate in the lab of Charles M. Perou, PhD, at UNC Lineberger Comprehensive Cancer Center, will present findings that identified molecular features responsible for the development and progression of metastatic breast cancer at the 2022 American Association for Cancer Research annual meeting. (Presentation: Abstract LB176/4, Tuesday, April 12, 3:20 p.m. ET, Room 217-219, Ernest N. Morial Convention Center in New Orleans.)

11 Apr 2022

DNA News and Research

Further Reading

Study explores role of APOBEC-mediated RNA editing in SARS-CoV-2 fitness

Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

Single-dose vaccine delivers protection against cervical cancer-causing HPV comparable to 2 or 3-dose regimes

COVID-19 may affect a group of biochemical reactions called one-carbon metabolism

Dietary influences on long COVID in children

Regulation of alternative splicing goes haywire in cells of a newly formed embryo

Researchers identify certain gene regulation signatures in CAR T-resistant leukemia patients

Bioprinting for bone repair enhanced with two growth factor encoding genes

New bioinformatics platform predicts optimal treatment combinations for cancer patients

Researchers discover new way to inhibit key mutated gene underlying tumor growth

Research using kidney organoids may lead to new targets to help prevent or treat CKD

Experimental tool can precisely pick out interactions between immune cell and target antigen

Novel Hendra virus variant detected in flying fox urine

Scientists find critical role for Hippo signaling pathway in COVID-19 pathogenesis

Drugs targeting DNA damage response pathway show therapeutic potential against advanced solid tumors

Study finds molecular features responsible for the development of metastatic breast cancer

Alternative anti-HIV strategy generates promising results in a phase I clinical trial

Evidence of an increased risk of neurodegeneration after SARS-CoV-2 infection

New instrument will help Columbia scientists to study heavy ion radiation therapy

Exploring evolutionary trajectories of SARS-CoV-2 interacting proteins in bats and primates

Understanding the DNA Damage Response in Innate Immunity eBook

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