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Chaotic genetic changes drive the growth of melanomas

Melbourne researchers have revealed how melanoma cells are flooded with DNA changes as this skin cancer progresses from early, treatable stages through to fatal end-stage disease.

22 Mar 2021

Could nanoparticle vaccines offer broad protection against sarbecoviruses?

To understand the ability of SARS-CoV-2 vaccine-elicited antibodies to neutralize and protect against emerging variants (that are pathogenic) and other sarbecoviruses, a large team of researchers studied immunity by receptor-binding domain nanoparticle vaccines. They showed that a clinical-stage multivalent SARS-CoV-2 receptor-binding domain nanoparticle vaccine (SARS-CoV-2 RBD-NP) protected mice from the SARS-CoV-2-induced disease.

22 Mar 2021

New study to identify prenatal and early childhood markers of high risk for food allergy and eczema

A study to identify prenatal and early childhood markers of high risk for food allergy and atopic dermatitis, or eczema, as well as biological pathways that lead to these conditions, has begun.

22 Mar 2021

Blocking folate metabolism could reduce SARS-CoV-2 viral replication in infected cells

The novel beta-coronavirus virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and coronaviruses, in general, alter the host's cellular metabolism to support massive production of ~30 kB viral genomes and subgenomic viral RNAs. However, how this is achieved is largely unknown.

21 Mar 2021

Joint project aims to establish automated system for SARS-CoV-2 analysis in wastewater

On March 19, 2021, Hokkaido University, Robotic Biology Institute Inc., iLAC Co., Ltd., and Shionogi & Co., Ltd. have entered into a memorandum of understanding (MOU) toward the establishment of an automated system for the analysis of the novel coronavirus (SARS-CoV-2) in wastewater.

20 Mar 2021

Newly discovered enzyme on deadly fungus may be the key to fight fungal infection

Aspergillus fumigatus kills as many people as malaria and tuberculosis, but is less known. It is found "everywhere", for example in the soil or in our compost, but is not normally dangerous to healthy people.

20 Mar 2021

Underrepresentation in genomic databases may affect therapy selection for minority patients

Low representation of minority groups in public genomic databases may affect therapy selection for Black patients with cancer, according to new Mayo Clinic research published in npj Precision Oncology.

19 Mar 2021

Developing a COVID-19 vaccine using inactivated E. coli

A team of researchers inactivated whole-cell E.coli with a reduced genome and utilized this to express coronavirus-specific fusion peptides, demonstrating a potent anamnestic response.

19 Mar 2021

SARS-CoV-2 spike stimulates hyperinflammation via Toll-like receptor 2

A new study, released on the bioRxiv* preprint server, describes the mechanism of inflammation in severe COVID-19, besides revealing a potential new therapeutic target to modulate the severity of COVID-19.

19 Mar 2021

DNA spike-ins increase reliability of amplicon-based sequencing of SARS-CoV-2 genomes

In the interests of cost-effectiveness and rapidity, amplicon-based sequencing of the viral genome has been used to provide a sensitive means of genomic surveillance. A new preprint, which was released on the bioRxiv* server, shows how this can be tweaked to make it a reliable source of genomic data by reducing the known potential for contamination.

19 Mar 2021

Identifying druggable targets on an essential SARS-CoV-2 protein

In a research paper recently uploaded to the preprint server bioRxiv by Newman et al. (March 15th, 2021) the structure and role of one such protein: NSP13, is investigated, with two appealingly druggable targets being identified, possibly opening a new route towards a novel SARS-CoV-2 antiviral agent.

18 Mar 2021

Weight loss induced by diet and bariatric surgery has different impact on mitochondria in fat tissue

Dieting impairs the energy-producing machinery of fat tissue, potentially resulting in weight regain. In contrast, as indicated by a recently completed European study coordinated by the University of Helsinki, weight loss surgery gives a boost to mitochondria, improving the gene expression of these cellular engines.

18 Mar 2021

Study investigates how genetic variants contribute to increased risk of lung cancer

Lung cancer is the leading cause of cancer death in the U.S. for both men and women. While risk for this disease can be influenced by environmental and lifestyle factors like smoking, studies estimate that 18% of lung cancer cases are due to inherited genetic variants.

18 Mar 2021

Antidiabetic drug could help reduce chronic inflammation in people living with HIV

Metformin, a drug used to treat type-2 diabetes, could help reduce chronic inflammation in people living with HIV (PLWH) who are being treated with antiretroviral therapy (ART), according to researchers at the University of Montreal Hospital Research Centre.

18 Mar 2021

GMP-Ready Helper Plasmids for AAV Production

Manufactured in dedicated clean-rooms with mandated changeovers before new production cycles - AMSBIO introduces new pHelper-Kan plasmid DNA optimized for Adeno-Associated Virus (AAV) manufacturing.

18 Mar 2021

New way to enhance treatment outcomes for breast cancer

Breast cancer is the most common cancer in women worldwide and the second most common cancer overall. Although it can now be treated with drugs, many of these drugs mysteriously stop working after some time, causing a relapse.

18 Mar 2021

The role of S-acylation in the enhancement of SARS-CoV-2 infectivity

A new study published on the bioRxiv server focuses on the role of S-acylation in the SARS-CoV-2 infection cycle. It has also characterized Spike acylation and has also identified other acylated viral proteins and host enzymes involved in the process of infection. Further, it has also revealed the importance of acylation in viral biogenesis and infection.

18 Mar 2021

Genome News and Research

Chaotic genetic changes drive the growth of melanomas

Could nanoparticle vaccines offer broad protection against sarbecoviruses?

New study to identify prenatal and early childhood markers of high risk for food allergy and eczema

Blocking folate metabolism could reduce SARS-CoV-2 viral replication in infected cells

Joint project aims to establish automated system for SARS-CoV-2 analysis in wastewater

Newly discovered enzyme on deadly fungus may be the key to fight fungal infection

Underrepresentation in genomic databases may affect therapy selection for minority patients

Developing a COVID-19 vaccine using inactivated E. coli

SARS-CoV-2 spike stimulates hyperinflammation via Toll-like receptor 2

DNA spike-ins increase reliability of amplicon-based sequencing of SARS-CoV-2 genomes

Identifying druggable targets on an essential SARS-CoV-2 protein

Weight loss induced by diet and bariatric surgery has different impact on mitochondria in fat tissue

Study investigates how genetic variants contribute to increased risk of lung cancer

Antidiabetic drug could help reduce chronic inflammation in people living with HIV

GMP-Ready Helper Plasmids for AAV Production

New way to enhance treatment outcomes for breast cancer

The role of S-acylation in the enhancement of SARS-CoV-2 infectivity

New SARS-CoV-2 variant in France appears undetectable by PCR

Long noncoding RNA plays a vital role in mobilizing immune response after organ transplantation

INTEGRA’s electronic pipettes enable reproducible analysis in microbial evolution research

The art of CRISPR: The power and promise of gene editing eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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