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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

How short-term nighttime carb restriction boosts exercise and burns fat

Dietary modifications, like the sleep-low method, may improve exercise performance by optimizing glycogen storage and fat metabolism. A study in Nutrients shows night-time carbohydrate restriction benefits endurance and weight management.

10 Jul 2024

Stem-like cells found to drive growth of aggressive pediatric brain tumors

A team of researchers at Baylor College of Medicine, Texas Children's Hospital, the Hospital for Sick Children in Toronto and collaborating institutions has identified and located a population of stem-like cells that initiates and maintains Group 3 medulloblastoma (Gr3-MB) in the developing brain.

9 Jul 2024

UK sugar tax reduces daily sugar intake in children and adults, study finds

Daily sugar intake fell by around 5 g in children and by around 11 g in adults in the 12 months following the introduction of the UK's 'sugar tax', formally known as the Soft Drinks Industry Levy, finds an analysis of 11 years of survey data, published online in the Journal of Epidemiology & Community Health.

9 Jul 2024

Transforming growth factor beta inhibition boosts NK cell therapy against hepatocellular carcinoma

Researchers at University of California San Diego have found that the most common form of liver cancer - one with a high mortality rate - can be better targeted and treated using an innovative new stem cell-derived therapy, according to a recently published study in Cell Stem Cell.

9 Jul 2024

New platform developed to probe the function of genes involved in metabolism

A multidisciplinary research team has developed a discovery platform to probe the function of genes involved in metabolism - the sum of all life-sustaining chemical reactions.

9 Jul 2024

COVID-19 and metallic taste: Study connects immunoglobulin levels to sensory impairment

Researchers investigated whether COVID-19-related sensory deficiencies are associated with transcriptome changes in the foliate papillae area of the tongue.

9 Jul 2024

Semaglutide linked to increased risk of severe eye condition NAION in new study

Research shows semaglutide users face a significantly higher risk of developing non-arteritic anterior ischemic optic neuropathy (NAION) compared to users of other medications for diabetes and obesity.

8 Jul 2024

How does SARS-CoV-2 cause lymphopenia when T cells barely express ACE-2 receptors?

Researchers reveal both direct and indirect mechanisms of SARS-CoV-2-induced lymphopenia, highlighting the role of CD147 and alternative viral entry routes into T cells.

8 Jul 2024

Semaglutide and very-low calorie diet combo shows superior results in managing type 2 diabetes

A study from the University of Nottingham shows that combining Semaglutide with a very-low calorie diet significantly improves weight loss and glycemic control in type 2 diabetes patients.

8 Jul 2024

Research reveals immune suppression link between cancer and pregnancy

To understand why some cancers successfully circumvent the immune system to grow unchecked, researchers turned to pregnancy.

8 Jul 2024

UQ researchers unlock crucial molecular secrets of aging in cells

University of Queensland researchers have unlocked crucial molecular secrets of aging in cells, potentially paving the way to improve quality of life as people age.

8 Jul 2024

Case Western Reserve University receives $1.5M grant for oral drug trial to prevent blindness in RP patients

There's only one U.S. Food and Drug Administration-approved therapy for an inherited retinal disease, and dozens of retinitis pigmentosa (RP) genes for which no therapy is available.

8 Jul 2024

Small molecule discovery offers hope for treatment of Angelman syndrome

Angelman syndrome is a rare genetic disorder caused by mutations in the maternally-inherited UBE3A gene and characterized by poor muscle control, limited speech, epilepsy, and intellectual disabilities.

8 Jul 2024

Scientists identify over 5000 high-risk cancer gene variants

Over 5,000 genetic variants that enable certain cancers to thrive have been identified by scientists, along with a potential therapeutic target to treat or even prevent these cancers from developing.

8 Jul 2024

Machine learning identifies cancer-driving mutations at CTCF binding sites

Researchers developed a machine learning tool, CTCF-INSITE, to identify mutational hotspots at persistent CTCF binding sites across various cancers, highlighting their role in genomic structure disruption and cancer progression.

7 Jul 2024

Novel antiviral protein SAMD9L blocks HIV-1 and other lentiviruses

Researchers discovered that interferon-stimulated SAMD9L restricts HIV-1 and other lentiviruses by inhibiting viral translation and endosomal trafficking, while SAMD9 enhances HIV-1 replication.

7 Jul 2024

Experts produce consensus statement on sex and gender disparities in resilience to Alzheimer's

An international panel of experts led by the Barcelona Institute for Global Health (ISGlobal), a centre supported by the "la Caixa" Foundation, under the umbrella of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment, has produced a consensus statement on sex and gender disparities in resilience to Alzheimer's disease and call for incorporating these differences in future research.

5 Jul 2024

Scientists map all the possible outcomes of changes to key tumor-suppressing gene

Researchers at the Francis Crick Institute have mapped all the possible outcomes of changes to a tumor-suppressing gene called VHL, the first step in a huge research endeavor to unpick the outcomes of tens of thousands of genetic variations in genes associated with cancer.

5 Jul 2024

Heparan-sulfate proteoglycans found to influence Alzheimer's cell pathology

The impact of heparan-sulfate-modified proteoglycans (HSPGs) on Alzheimer's disease-associated pathways.

5 Jul 2024

New signaling pathway identified in aural migraine headaches

The rapid influx of cerebral spinal fluid (CSF) and protein solutes released during cortical spreading depression (CSD) in the brain activates neurons to trigger aural migraine headaches, according to a new mouse study.

4 Jul 2024