Clinical Trial News and Research

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Repairing faulty drains could be key to unlocking the potential of Alzheimer's therapies

Experimental Alzheimer's drugs have shown little success in slowing declines in memory and thinking, leaving scientists searching for explanations.

29 Apr 2021

Safety and efficacy of Pfizer and AstraZeneca COVID-19 vaccines even better than clinical trials predicted

Researchers in the UK and United States have demonstrated the efficacy of one dose of either the Pfizer-BioNTech or Oxford-AstraZeneca vaccine against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a real-world community setting in the UK.

28 Apr 2021

FDA issues noncompliance notice for failing to submit clinical trial summary results to ClinicalTrials.gov

Being transparent about the results of completed clinical trials enables important advances in the development of medical products and helps ensure a safe, effective and efficient clinical research enterprise.

28 Apr 2021

Purified exosomal product accelerates wound healing in preclinical models

Difficult-to-treat, chronic wounds in preclinical models healed with normal scar-free skin after treatment with an acellular product discovered at Mayo Clinic.

28 Apr 2021

Young people of color with a higher income more likely to participate in cancer clinical trials

People of color, those with a higher income and younger individuals are more likely to participate in clinical trials during their cancer treatment according to a new study from the University of Missouri School of Medicine.

28 Apr 2021

Study examines mRNA COVID-19 vaccine’s effectiveness across age and gender

The findings reveal that although the two-dose vaccine regimen initially induces robust antibody response in all age groups, older male individuals are particularly associated with a gradual decline in vaccine-induced immunity six weeks after the second vaccine dose.

28 Apr 2021

Clinical trial to test existing antibiotic for treating serious S. aureus infections begins

A clinical trial to test the antibiotic dalbavancin for safety and efficacy in treating complicated Staphylococcus aureus (S. aureus) bacteremia has begun.

27 Apr 2021

UCI biologists develop new mouse model to study late-onset Alzheimer's disease

University of California, Irvine biologists have developed a new genetically engineered mouse model that, unlike its predecessors, is based on the most common form of Alzheimer's disease.

27 Apr 2021

ANTICOV clinical trial to test new treatment for people with mild-to-moderate COVID-19 in Africa

The ANTICOV clinical trial, conducted in 13 African countries, has started the recruitment of participants to test a new drug combination, nitazoxanide + ciclesonide, to treat people with mild-to-moderate COVID-19 before their cases become severe.

27 Apr 2021

Menopausal symptoms in breast cancer patients could be reduced through CBT delivered by nurses

Menopausal symptoms - hot flushes and night sweats – experienced by women with breast cancer can be reduced through group cognitive behavioral therapy (CBT) delivered by breast care nurses, a new clinical trial reveals.

27 Apr 2021

A new roadmap for advancing TBI care

Brain research and advocacy nonprofit Cohen Veterans Bioscience (CVB) today announced the launch of a National TBI Precision Solutions Research Roadmap, with the advent of the first in a series of publications resulting from its Brain Trauma Blueprint framework program.

26 Apr 2021

Bariatric surgery reduces brain pressure in patients with idiopathic intracranial hypertension

Weight loss surgery is more effective than dieting to reduce brain pressure that can cause blindness in patients with a neurological condition, finds a study led by the University of Birmingham and University Hospitals Birmingham NHS Foundation Trust.

26 Apr 2021

New treatment approach could be life-changing for many stroke patients

Every year, more than 795,000 people in the United States have a stroke. Of these, approximately 80% lose arm function and as many as 50-60% of this population still experience problems six months later.

26 Apr 2021

Using estrogen to target drug-resistant breast cancer in mice

Researchers at Dartmouth's and Dartmouth-Hitchcock's Norris Cotton Cancer Center (NCCC) hope to make estrogen therapy a more accessible treatment option for breast cancer patients who could benefit from it.

26 Apr 2021

Recombinant protein vaccine fails expectations for SARS-CoV-2 neutralization

New interim results of a phase 1-2 clinical trial published in The Lancet Infectious Diseases tested the safety and effectiveness of an adjuvanted recombinant protein vaccine against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) called CoV2 preS dTM.

26 Apr 2021

Potential new COVID vaccine from Australia

Phase 1 trial results published in The Lancet Infectious Diseases found a new subunit vaccine —an MF59-adjuvanted subunit vaccine using recombinant spike glycoprotein stabilized in a prefusion conformation by a novel molecular clamp — targeting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was safe and effective in producing an antigen-specific response in healthy adults.

26 Apr 2021

High dose of vitamin D does not have a beneficial effect on moderate or severe COVID-19 patients

Can a high dose of vitamin D administered on admission to hospital improve the condition of patients with moderate or severe COVID-19? The answer is no, according to a Brazilian study published in the Journal of the American Medical Association.

23 Apr 2021

Study reports on safety of COVID-19 mRNA vaccines in pregnancy

Researchers used different surveillance systems in the United States to track adverse outcomes after coronavirus disease 2019 (COVID-19) vaccination in pregnant people and found no major safety flags.

23 Apr 2021

NIH to conduct large trial for COVID-19 polyclonal antibody therapies

The National Institutes of Health (NIH) in the USA are to conduct a large-scale clinical trial to evaluate a new fully-human polyclonal antibody therapy targeted at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of coronavirus disease 2019 (COVID-19).

23 Apr 2021

Contralateral esophagus sparing technique can prevent complication in lung cancer patients

For many patients with localized lung cancer (non-small-cell lung carcinoma and small cell lung carcinoma), high-dose radiation with concurrent chemotherapy is a potential cure. Yet this treatment can cause severe, acute inflammation of the esophagus (esophagitis) in about one in five patients, requiring hospitalization and placement of a feeding tube.

23 Apr 2021

Clinical Trial News and Research

Repairing faulty drains could be key to unlocking the potential of Alzheimer's therapies

Safety and efficacy of Pfizer and AstraZeneca COVID-19 vaccines even better than clinical trials predicted

FDA issues noncompliance notice for failing to submit clinical trial summary results to ClinicalTrials.gov

Purified exosomal product accelerates wound healing in preclinical models

Young people of color with a higher income more likely to participate in cancer clinical trials

Study examines mRNA COVID-19 vaccine’s effectiveness across age and gender

Clinical trial to test existing antibiotic for treating serious S. aureus infections begins

UCI biologists develop new mouse model to study late-onset Alzheimer's disease

ANTICOV clinical trial to test new treatment for people with mild-to-moderate COVID-19 in Africa

Menopausal symptoms in breast cancer patients could be reduced through CBT delivered by nurses

A new roadmap for advancing TBI care

Bariatric surgery reduces brain pressure in patients with idiopathic intracranial hypertension

New treatment approach could be life-changing for many stroke patients

Using estrogen to target drug-resistant breast cancer in mice

Recombinant protein vaccine fails expectations for SARS-CoV-2 neutralization

Potential new COVID vaccine from Australia

High dose of vitamin D does not have a beneficial effect on moderate or severe COVID-19 patients

Study reports on safety of COVID-19 mRNA vaccines in pregnancy

NIH to conduct large trial for COVID-19 polyclonal antibody therapies

Contralateral esophagus sparing technique can prevent complication in lung cancer patients

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