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Study points to the possibility of using cholesterol-lowering drugs to treat aggressive colorectal tumors

Hard-to-detect colorectal pre-cancerous lesions known as serrated polyps, and the aggressive tumors that develop from them, depend heavily on the ramped-up production of cholesterol, according to a preclinical study from researchers at Weill Cornell Medicine.

18 Dec 2023

‘They see a cash cow’: Corporations could consume $50 billion of opioid settlements

The marketing pitches are bold and arriving fast: Invest opioid settlement dollars in a lasso-like device to help police detain people without Tasers or pepper spray.

18 Dec 2023

Experimental drug paired with a standard-care medication offers hope for kidney disease patients

In a clinical trial of patients with chronic kidney disease, an experimental drug significantly reduced albuminuria - albumin in urine, a sign of kidney damage - for 50% of participants.

15 Dec 2023

$9M awarded to study HIV and substance use at intersection of vulnerable populations

The Institute of Human Virology (IHV) at the University of Maryland School of Medicine (UMSOM) received an annual award for $3 million funded by the NIH Office of AIDS Research.

15 Dec 2023

Unlocking radiation resistance: Missing protein key to suppressing cancer-fighting cells

A new study finds that radiation therapy (RT) suppresses a key protein called bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) and activates immune suppressive cells.

15 Dec 2023

Researchers reveal a connection between cellular metabolism and depression, suicidal ideation

Major depressive disorder affects 16.1 million adults in the United States and costs $210 billion annually. While the primary symptoms of depression are psychological, scientists and doctors have come to understand that depression is a complex disease with physical effects throughout the body.

15 Dec 2023

Addiction stigma discourages many people from seeking treatment

Addiction is one of society's most misunderstood and rebuked health conditions. That stigma discourages many people from seeking treatment for substance dependence, according to a new report published in Psychological Science in the Public Interest, a journal of the Association for Psychological Science.

15 Dec 2023

Science’s Breakthrough of the Year: GLP-1 agonists can blunt obesity-associated health problems

Science has named the development of glucagon like peptide-1 (GLP-1) agonists and this year's discovery that these drugs can blunt obesity-associated health problems as its 2023 Breakthrough of The Year.

15 Dec 2023

New AI framework can rapidly identify new use cases for existing therapeutics

Scientists at Klick Applied Sciences have created an artificial intelligence framework that can rapidly identify new use cases for existing therapeutics, according to findings presented Friday at the NeurIPS conference that could greatly improve the drug repurposing process and transform the pharmaceutical industry.

15 Dec 2023

How safe are GLP-1R agonists in early pregnancy?

JAMA Internal Medicine study examines the safety of GLP-1 receptor agonists and other second-line antidiabetic medications during early pregnancy, finding no significant increase in congenital anomalies compared to insulin use.

14 Dec 2023

Uncovering barriers to heart failure medication access for low-income patients

People who live in neighborhoods with higher levels of poverty and unemployment are less likely to fill their heart-failure drug prescriptions than those living in wealthier areas, a new study shows.

14 Dec 2023

Unlocking the secrets of our "dark genome": Scientists crack the code of LINE-1

A multidisciplinary study published in Nature has elucidated the structure of the machinery responsible for writing much of our "dark genome" - the 98 percent of our DNA that has largely unknown biological function.

14 Dec 2023

Researchers unveil new way to sensitize resistant tumors to treatment

Resistance to therapies is one of the obstacles to overcome in cancer treatments. Understanding the mechanisms of this resistance is essential to design strategies that favor tumor cell death.

14 Dec 2023

Novel drug combinations could protect snakebite victims from devastating injuries

New drug combinations could protect snakebite victims from the devastating, life-changing injuries caused by toxic venom, promising new research led by Liverpool School of Tropical Medicine suggests.

14 Dec 2023

Researchers develop humanized mouse model for macrophage-targeted cancer immunotherapy

Mice with human immune cells are a new way of testing anti-cancer drugs targeting the immune system in pre-clinical studies.

14 Dec 2023

UK drug regulators failing to protect patients from harmful weight loss

UK organizations responsible for protecting the public from prescription-only drug adverts are putting patients at risk from the harms of weight loss drugs by not enforcing the law, reveals an investigation published by The BMJ today.

14 Dec 2023

Association of genetically proxied PDE5 inhibition with measures of fertility, sexual behavior, and wellbeing

Researchers performed a two-sample Mendelian randomization analysis to investigate the associations between genetically proxied suppression of PDE5, a recognized pharmacological target for erectile dysfunction, fertility, subjective wellness, and sexual behavior.

14 Dec 2023

Advancements in food allergy research promise improved diagnosis and treatment options

A review in the Journal of Allergy and Clinical Immunology discusses the global trends in food allergy prevalence, with stabilization in developed regions and an increase in developing countries, alongside advancements in understanding the mechanisms, diagnosis, and treatment of food allergies.

13 Dec 2023

Adolescent illicit drug use stays below pre-pandemic levels in 2023, survey finds

The percentage of teenagers reporting they used any illicit substances in 2023 held steady below the pre-pandemic levels reported in 2020, according to the latest results from the Monitoring the Future survey.

13 Dec 2023

Targeting cholesterol metabolism for the treatment of serrated colorectal neoplasms

13 Dec 2023

Drugs News and Research

Study points to the possibility of using cholesterol-lowering drugs to treat aggressive colorectal tumors

‘They see a cash cow’: Corporations could consume $50 billion of opioid settlements

Experimental drug paired with a standard-care medication offers hope for kidney disease patients

$9M awarded to study HIV and substance use at intersection of vulnerable populations

Unlocking radiation resistance: Missing protein key to suppressing cancer-fighting cells

Researchers reveal a connection between cellular metabolism and depression, suicidal ideation

Addiction stigma discourages many people from seeking treatment

Science’s Breakthrough of the Year: GLP-1 agonists can blunt obesity-associated health problems

New AI framework can rapidly identify new use cases for existing therapeutics

How safe are GLP-1R agonists in early pregnancy?

Uncovering barriers to heart failure medication access for low-income patients

Unlocking the secrets of our "dark genome": Scientists crack the code of LINE-1

Researchers unveil new way to sensitize resistant tumors to treatment

Novel drug combinations could protect snakebite victims from devastating injuries

Researchers develop humanized mouse model for macrophage-targeted cancer immunotherapy

UK drug regulators failing to protect patients from harmful weight loss

Association of genetically proxied PDE5 inhibition with measures of fertility, sexual behavior, and wellbeing

Advancements in food allergy research promise improved diagnosis and treatment options

Adolescent illicit drug use stays below pre-pandemic levels in 2023, survey finds

Targeting cholesterol metabolism for the treatment of serrated colorectal neoplasms

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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