Cardiomyopathy News and Research

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Cardiomyopathy is a group of diseases with primary, usually diffuse, involvement of the myocardium. The myocardial disease is not secondary to ischaemic, valvular, congenital or pericardial disease.

Gene editing technology predicts heart disease risk

Scientists could now use gene editing and stem cell technologies to predict whether carrying a specific gene variant increases the risk of heart disease.

18 Jun 2018

Penn research team identifies novel therapeutic target for heart disease

Changes in cellular struts called microtubules (MT) can affect the stiffness of diseased human heart muscle cells, and reversing these modifications can lessen the stiffness and improve the beating strength of these cells isolated from transplant patients with heart failure, found researchers from the Perelman School of Medicine at the University of Pennsylvania.

12 Jun 2018

New cell-based technologies could help improve understanding of muscle-wasting disease

Researchers from Queen Mary University of London have developed new cell-based technologies which could help improve understanding of the muscle-wasting disease Duchenne muscular dystrophy (DMD) and test potential drugs for the disease.

6 Jun 2018

Young cancer survivors have higher risk of pregnancy associated heart failure, shows study

Girls who survive cancer have a higher risk of developing a deadly heart disease when pregnant later in life, according to a study presented today at Heart Failure 2018 and the World Congress on Acute Heart Failure, a European Society of Cardiology congress.

28 May 2018

Research suggests link between faulty gene, alcohol, and heart failure

The researchers investigated faulty versions of a gene called titin which are carried by one in 100 people or 600,000 people in the UK.

25 May 2018

HCM mutation prevents the heart from increasing pumping force, study shows

Researchers from Washington State University have discovered how a genetic mutation linked to hypertrophic cardiomyopathy (HCM) disrupts the heart's normal function.

21 May 2018

Genomic science can help healthcare professionals to identify, treat inherited cardiac conditions

The family history questions asked during patient assessments are becoming even more important with the rise of precision medicine and genetic testing.

11 May 2018

Using human induced pluripotent stem cells for therapeutic drug testing

Researchers at Li Ka Shing Faculty of Medicine of The University of Hong Kong have successfully demonstrated the use of human induced pluripotent stem cells from patients' skin cells for therapeutic drug testing.

8 May 2018

Circulating immune cells found to worsen, rather than improve heart disease

New research led by investigators at Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center suggests that the location of immune cells in the body determines whether they help or harm the development of heart disease.

3 May 2018

Teen patient gets a new lease on life

At just 18 years old, Megan Gagliardi was told she might die from a rare genetic heart condition. Now, thanks in part to UAB Medicine's Comprehensive Transplant Institute (CTI), she is celebrating her recent engagement and an important six-year anniversary - all as the University of Alabama at Birmingham celebrates 50 years of transplant success.

19 Apr 2018

Research team identifies new mutation behind heart failure in South Asians

An international research team involving Karolinska Institutet has identified a new mutation in South Asians that, in combination with a known mutation in the same gene, increases the risk of cardiomyopathy and heart failure.

12 Apr 2018

Researchers aim to reveal new direction for Barth syndrome treatment

The Barth Syndrome Foundation recently announced awardees from its 2017 grant cycle. Miriam Greenberg, Ph.D., professor of biological sciences in the College of Liberal Arts and Sciences at Wayne State University and a resident of Ann Arbor, Michigan, received a one-year, $50,000 grant for the project, "Cardiolipin activates pyruvate dehydrogenase (PDH) - a potential new target for treatment of Barth syndrome."

28 Mar 2018

Heart patients experience increase in quality of life after transcatheter aortic valve replacement

Patients who undergo a transcatheter aortic valve replacement, or TAVR -- a minimally-invasive surgical procedure that repairs a damaged heart valve -- experienced a significant increase in their quality of life, according to a new study by researchers at the Intermountain Medical Center Heart Institute in Salt Lake City.

12 Mar 2018

Study identifies genetic defect linked to heart failure in African Americans

Heart failure is more common, develops earlier and results in higher rates of illness and death in African Americans than in whites.

7 Mar 2018

Hypertrophic cardiomyopathy patient maintains active lifestyle while minimizing risk

A group of cardiologists is changing the conversation about a form of heart disease and exercise. One patient details how she's maintaining an active lifestyle while minimizing risk.

24 Feb 2018

Patients at risk of heart disease do not always understand genetic test results

University of Sydney researchers are raising concerns over the need for informed decision making for genetic testing after a study published today finds patients at risk of inherited heart disease do not always understand test results or the impact results will have on their life.

23 Feb 2018

Scientists use ‘big-data’ to define burden of sarcoidosis

Physician-scientists from the University of Alabama at Birmingham using "big-data" recently summarized in the Journal of the American Heart Association the prevalence of cardiovascular manifestations, rates of defibrillator placement and predictors of in-hospital mortality in sarcoidosis - a disorder that affects multiple organs.

7 Feb 2018

Tumor activity found in male rats exposed to radiofrequency radiation

High exposure to radiofrequency radiation in rodents resulted in tumors in tissues surrounding nerves in the hearts of male rats, but not female rats or any mice, according to draft studies from the National Toxicology Program.

2 Feb 2018

Researchers discover why exercise is good and high blood pressure is bad for the heart

When the heart is put under stress during exercise, it is considered healthy. Yet stress due to high blood pressure is bad for the heart. Why? And is this always the case? Researchers of the German Centre for Cardiovascular Research and of Heidelberg University Hospital have obtained new findings which indicate that a previously undetected signal pathway causes or protects from heart failure - depending on the type of stress.

9 Jan 2018

New, sensitive screening test may allow clinicians to accurately detect Pompe disease

Researchers identified a new, more sensitive screening test to recognize Pompe disease, a metabolic disorder affecting cellular processing of glycogen in numerous tissues of the body.

2 Jan 2018