Nucleotide News and Research

RSS

Research explores the utility of epigenetically predicted BMI

DNA methylation is an accurate predictor of current BMI and a poor predictor of future BMI.

18 Jan 2023

Tight transmission bottlenecks may limit the evolution of SARS-CoV-2 variants

A new study describes that tight transmission bottlenecks restrict the evolution of SARS-CoV-2 in the transmission chain. SARS-CoV-2 is the causative pathogen of the COVID-19 pandemic.

18 Jan 2023

Combination of multiple maps uncovers new genetic risk factor for AMD

Combining a map of gene regulatory sites with disease-associated loci has uncovered a new genetic risk factor of adult-onset macular degeneration (AMD), according to a new study publishing January 17th in the open access journal PLOS Biology by Ran Elkon and Ruth Ashery-Padan of Tel Aviv University, Israel, and colleagues.

18 Jan 2023

Exploring a novel amplicon-based mpox virus sequencing strategy

Researchers described the development of a sequencing strategy based on amplicons for mpox detection.

18 Jan 2023

Preclinical study shows the therapeutic value of kinetin against SARS-CoV-2

Researchers investigated the ability of kinetin (N6-furfurylaminopurine, MB-905) to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proliferation in vitro.

17 Jan 2023

Researchers analyze the ancestry components in modern and historic VARV genomes

A recent study published in Microbial Genomics analyzed the molecular evolution of the variola virus (VARV)

13 Jan 2023

Study suggests a link between the protein-coding gene TREM2 and obesity in females

A recent Scientific Reports study has investigated the link between TREM2 expression and human obesity, based on two large public datasets, namely, the UK Biobank (UKB) and the Genotype-Tissue Expression (GTEx) project.

11 Jan 2023

The main source of editing of the mpox virus genome during the 2022 outbreak

Researchers investigated the main source of editing of the 2022 mpox virus genome.

11 Jan 2023

Genomic analysis of mpox virus genomes reveal multiple lineages with human-to-human transmissibility

Researchers from Nigeria and the United Kingdom (U.K.) analyzed mpox virus genomes and found that divergent lineages of the mpox virus exhibiting human-to-human transmission existed in the Nigerian population before the 2022 spread of the virus outside of the endemic regions.

10 Jan 2023

Researchers investigate Scandinavian history across 2,000 years

Researchers investigated the history of Scandinavia from the Roman period (between 1.0 CE and 400.0 CE) to the present, spanning over 2,000 years.

10 Jan 2023

Study shows XBB.1.5 exhibits a substantially higher hACE2-binding affinity compared to BQ.1.1 and XBB/XBB.1

Researchers investigated the reasons for the rapid advent of SARS-CoV-2 XBB.1.5, a sublineage of the Omicron recombinant mutant XBB in the USA.

6 Jan 2023

Deep learning tool identifies mosaic mutations that cause disease

Genetic mutations cause hundreds of unsolved and untreatable disorders. Among them, DNA mutations in a small percentage of cells, called mosaic mutations, are extremely difficult to detect because they exist in a tiny percentage of the cells.

2 Jan 2023

Horizontal gene transfer from mother to infant influences gut microbiome assembly, neurodevelopment, and immune maturation in infants

Researchers used a multi-omics approach to profile the gut microbiomes and metabolomes of mothers and infants to determine the vertical and horizontal transmission of bacterial species and strains as well as individual genes and understand the dynamics of the gut microbiome assembly that shape the development of the infant before and after birth.

29 Dec 2022

Enzyme that defends human cells against viruses may be a potential target for future cancer treatments

An enzyme that defends human cells against viruses can help drive cancer evolution towards greater malignancy by causing myriad mutations in cancer cells, according to a study led by investigators at Weill Cornell Medicine.

28 Dec 2022

Study shows de novo origination of functional microproteins

In a new study, researchers performed a genomic analysis to investigate the origination of human microproteins of biological importance.

23 Dec 2022

Mutations responsible for common inherited heart condition corrected using CRISPR-Cas9 therapy

Using the CRISPR-Cas9 gene editing system, UT Southwestern researchers corrected mutations responsible for a common inherited heart condition called dilated cardiomyopathy (DCM) in human cells and a mouse model of the disease.

21 Dec 2022

Immune-evading Mycobacterium tuberculosis prevents inflammatory responses by hijacking the host’s ubiquitin

A new study discussed the findings of Chai et al., which revealed that triple specificity protein phosphatase (ptpB) secreted by Mycobacterium tuberculosis inhibits pyroptosis and the release of cytokines by macrophages, allowing M. tuberculosis to invade the immune system.

19 Dec 2022

Nucleotide News and Research

Research explores the utility of epigenetically predicted BMI

Tight transmission bottlenecks may limit the evolution of SARS-CoV-2 variants

Combination of multiple maps uncovers new genetic risk factor for AMD

Exploring a novel amplicon-based mpox virus sequencing strategy

Preclinical study shows the therapeutic value of kinetin against SARS-CoV-2

Researchers analyze the ancestry components in modern and historic VARV genomes

Study suggests a link between the protein-coding gene TREM2 and obesity in females

The main source of editing of the mpox virus genome during the 2022 outbreak

Genomic analysis of mpox virus genomes reveal multiple lineages with human-to-human transmissibility

Researchers investigate Scandinavian history across 2,000 years

Study shows XBB.1.5 exhibits a substantially higher hACE2-binding affinity compared to BQ.1.1 and XBB/XBB.1

Deep learning tool identifies mosaic mutations that cause disease

Horizontal gene transfer from mother to infant influences gut microbiome assembly, neurodevelopment, and immune maturation in infants

Enzyme that defends human cells against viruses may be a potential target for future cancer treatments

Study shows de novo origination of functional microproteins

Mutations responsible for common inherited heart condition corrected using CRISPR-Cas9 therapy

Immune-evading Mycobacterium tuberculosis prevents inflammatory responses by hijacking the host’s ubiquitin

Next-generation sequencing could change research on sexual assault cases

Polymorphisms in human immunoglobulin heavy chain genes can influence the function of SARS-CoV-2 neutralizing antibodies

GOSH delivers world-first base-edited cell therapy for a patient with relapsed T cell leukemia

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

Applications Engineer

Latest News