Clinical Trial News and Research

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Survival data for immunotherapies should be re-analyzed for potential misinterpretation, indicates study

Immune checkpoint inhibitors have transformed cancer care to the point where the popular Cox proportional-hazards model provides misleading estimates of the treatment effect, according to a new study published April 15 in JAMA Oncology.

16 Apr 2021

Study finds that not all patients with elevated eye pressure need treatment to prevent vision loss

More than 20 years after the launch of a landmark clinical trial, follow-up examinations and analyses found that not all patients with elevated eye pressure need pressure-lowering treatment to prevent vision loss from glaucoma.

16 Apr 2021

Trial results show leishmaniasis vaccine is safe and induces immune responses in patients

The results of the first clinical trial of a new vaccine for a neglected tropical disease have demonstrated that it is safe and induces immune responses in patients with the infection.

15 Apr 2021

COVID-19 vaccine INO-4800 shows efficacy against SARS-CoV-2 variants

Researchers in the United States have demonstrated the efficacy of the vaccine INO-4800 against variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

15 Apr 2021

Survey data shows strong readiness among young people for COVID-19 vaccination

As older teens and young adults become eligible for COVID-19 vaccination across the country, and younger teens await their turn, new survey data suggest a strong readiness that has grown since fall.

15 Apr 2021

Anti-diabetic drug phenformin may prompt stronger cancer-fighting activities

The anti-diabetic drug phenformin may prompt stronger cancer-fighting activities than its sister compound metformin, a finding that could have major implications for current and future clinical trials investigating both agents for their anti-cancer potential, according to researchers at Massachusetts General Hospital (MGH).

15 Apr 2021

Study may lead to new treatment for incurable brain cancer in children

Research by Australian scientists could pave the way to a new treatment for a currently incurable brain cancer in children called Diffuse Intrinsic Pontine Glioma, or DIPG. Affecting about 20 children in Australia each year, DIPG is a devastating disease with an average survival time of just nine months after diagnosis.

15 Apr 2021

Phase 3 trial finds corticosteroid inhaler speeds recovery time in COVID-19 patients

The corticosteroid budesonide shows promise in treating patients with mild COVID-19 infection. Interim analysis of the phase 3 PRINCIPLE clinical trial was posted to the medRxiv preprint server. Researchers found a 3-day faster recovery of COVID-19 symptoms in people at high risk for severe side effects administered a budesonide inhaler. There was also a 2.1% reduction in hospitalization and death.

14 Apr 2021

Biognosys announces strategic agreement with Siemens Healthineers

Biognosys announces today that it has established a strategic agreement with Siemens Healthineers through its clinical laboratory in Berkeley, California.

From Biognosys 14 Apr 2021

Risk of E.R. visit or hospitalization 82% lower in mAbs-treated SARS-CoV-2 patients: Study

Recently, researchers from the U.S. reviewed electronic health records of SARS-CoV-2 patients at a medical center that started mAb infusions in January 2021 with the support of the National Disaster Medical System, part of the U.S. Department of Health and Human Services. The study is published on the preprint server, medRxiv.

14 Apr 2021

Clinical trial of monoclonal antibody for treating respiratory disease in COVID-19 patients begins

A clinical trial testing the safety and efficacy of an investigational monoclonal antibody for treating people who are hospitalized with respiratory disease and low blood oxygen due to infection with SARS-CoV-2, the virus that causes COVID-19, has begun.

13 Apr 2021

Gene therapy may offer a new approach to preserving vision in people with retinitis pigmentosa

A gene therapy protects eye cells in mice with a rare disorder that causes vision loss, especially when used in combination with other gene therapies, shows a study published today in eLife.

13 Apr 2021

Baseline brain imaging should be considered in most metastatic kidney cancer patients, study suggests

The April 2021 issue of JNCCN - Journal of the National Comprehensive Cancer Network publishes new research from Memorial Sloan Kettering Cancer Center (MSK) and Gustave Roussy Institute, which suggests that baseline brain imaging should be considered in most patients with metastatic kidney cancer.

13 Apr 2021

Commonly used drug for neuromuscular diseases could also help prevent certain skin cancers

New data published by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute suggests that an oral drug currently used in the clinical setting to treat neuromuscular diseases could also help prevent a common form of skin cancer caused by damage from ultraviolet-B (UVB) radiation from the sun.

13 Apr 2021

Low health literacy may discourage men from selecting active surveillance for prostate cancer

Tumor gene profiling is a tool that can help patients with a cancer diagnosis make informed decisions about treatment.

13 Apr 2021

Research may lead to a significant breakthrough in the battle against deadly brain tumors

Groundbreaking research from Tel Aviv University may lead to a significant breakthrough in the battle against deadly brain cancer.

12 Apr 2021

Imbalanced bacterial community in the gums linked to Alzheimer's disease biomarker

Older adults with more harmful than healthy bacteria in their gums are more likely to have evidence for amyloid beta--a key biomarker for Alzheimer's disease--in their cerebrospinal fluid (CSF), according to new research from NYU College of Dentistry and Weill Cornell Medicine.

12 Apr 2021

CD40 drug before surgery can benefit patients with early-stage pancreatic cancer

Giving early-stage pancreatic cancer patients a CD40 immune-stimulating drug helped jumpstart a T cell attack to the notoriously stubborn tumor microenvironment before surgery and other treatments, according to a new study from researchers in the Abramson Cancer Center (ACC) at the University of Pennsylvania.

12 Apr 2021

Aneuploidy testing can be key in determining optimal treatment for lung cancer patients

Patients with non-small cell lung cancer (NSCLC) whose cancer cells have low levels of aneuploidy - an abnormal number of chromosomes - tend to respond better to immune checkpoint inhibitor drugs than patients with higher levels, Dana-Farber Cancer Institute researchers will report at the virtual AACR Annual Meeting 2021.

12 Apr 2021

Broadly neutralizing antibodies show promise in preventing tick-borne encephalitis in mice

Tick-borne encephalitis is a disease just as nasty as it sounds. Once bitten by an infected tick, some people develop flu-like symptoms that resolve quietly but leave behind rampant neurological disease--brain swelling, memory loss, and cognitive decline.

9 Apr 2021

Clinical Trial News and Research

Survival data for immunotherapies should be re-analyzed for potential misinterpretation, indicates study

Study finds that not all patients with elevated eye pressure need treatment to prevent vision loss

Trial results show leishmaniasis vaccine is safe and induces immune responses in patients

COVID-19 vaccine INO-4800 shows efficacy against SARS-CoV-2 variants

Survey data shows strong readiness among young people for COVID-19 vaccination

Anti-diabetic drug phenformin may prompt stronger cancer-fighting activities

Study may lead to new treatment for incurable brain cancer in children

Phase 3 trial finds corticosteroid inhaler speeds recovery time in COVID-19 patients

Biognosys announces strategic agreement with Siemens Healthineers

Risk of E.R. visit or hospitalization 82% lower in mAbs-treated SARS-CoV-2 patients: Study

Clinical trial of monoclonal antibody for treating respiratory disease in COVID-19 patients begins

Gene therapy may offer a new approach to preserving vision in people with retinitis pigmentosa

Baseline brain imaging should be considered in most metastatic kidney cancer patients, study suggests

Commonly used drug for neuromuscular diseases could also help prevent certain skin cancers

Low health literacy may discourage men from selecting active surveillance for prostate cancer

Research may lead to a significant breakthrough in the battle against deadly brain tumors

Imbalanced bacterial community in the gums linked to Alzheimer's disease biomarker

CD40 drug before surgery can benefit patients with early-stage pancreatic cancer

Aneuploidy testing can be key in determining optimal treatment for lung cancer patients

Broadly neutralizing antibodies show promise in preventing tick-borne encephalitis in mice

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