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Deep learning tool predicts hosts based on early SARS-CoV-2 samples

The study, which appeared on the pre-print server bioRxiv*, revealed how DeepHoF could help prevent future outbreaks that may become as large as the current pandemic.

24 Mar 2021

Researchers examine acriflavine's antiviral potential against SARS-CoV-2

Acriflavine is traditionally employed as a topical antiseptic, though has more recently been implicated as an antiviral agent at low doses, potentially by stimulating the production of interferon. In a new study recently uploaded to the bioRxiv* preprint server, the application of the drug to SARS-CoV-2 infection is investigated, demonstrating a broad activity towards a range of other betacoronaviruses.

24 Mar 2021

Modeling study predicts SARS-CoV-2 variants with high receptor binding affinity

A new study adds to the sum of knowledge about SARS-CoV-2, with respect to its natural and biologically significant mutations, using computational modeling of the virus-receptor interactions. Understanding how viral mutations affect the virus-host interactions is crucial for shaping proper strategies to control the virus.

24 Mar 2021

High throughput screening for COVID-19 with the VOYAGER pipette

The COVID-19 pandemic has slowed down research in many scientific areas, but for the Jain Lab in the Department of Chemical Engineering at the University of Florida, the pandemic has created an exciting opportunity to repurpose their work.

From INTEGRA Biosciences 24 Mar 2021

CureVac's COVID-19 vaccine protects mice against emerging SARS-CoV-2 variants

The CVnCoV mRNA vaccine showed neutralizing antibody levels and completely protected mice infected with the B.1.351 variant. No viral genomes were seen in oral swabs, lungs, or brain.

23 Mar 2021

Over-expression of LRRN4CL gene linked to metastasis of certain cancers to the lungs

A gene not previously linked to cancer has been shown to play a key role in the spread of certain cancers to the lungs, new research from scientists at the Wellcome Sanger Institute has shown.

23 Mar 2021

Researchers use new approach to detect COVID-19 in wastewater

There are many ways to test municipal wastewater for signs of the virus that causes COVID-19, but scientists in Houston have determined theirs is the best yet.

23 Mar 2021

Researchers use new approach to detect COVID-19 in wastewater

There are many ways to test municipal wastewater for signs of the virus that causes COVID-19, but scientists in Houston have determined theirs is the best yet.

23 Mar 2021

Simple SARS-CoV-2 mutations allow escape from the majority of polyclonal antibodies

The group identified a single class of antibodies that target a particular epitope on the RBD of SARS-CoV-2, suggesting that the human polyclonal response to SARS-CoV-2 infection is dominated by a worryingly narrow range of antibodies that target an epitope undergoing rapid mutation.

22 Mar 2021

Virginia Tech neuroscientist uses NIH grant to understand astrocytic processes in the healthy brain

Of all the worlds still to be explored, among the most mysterious may be closest to home. Indeed, it may be right between your ears.

22 Mar 2021

Anti-androgen drugs may help disarm coronavirus spike protein, stop progression of COVID-19

Hormone drugs that reduce androgen levels may help disarm the coronavirus spike protein used to infect cells and stop the progression of severe COVID-19 disease, suggests a new preclinical study from researchers in the Abramson Cancer Center at the University of Pennsylvania and published online in Cell Press's iScience.

22 Mar 2021

Inherited behaviors, traits that appear during adolescence may be related to adult cannabis use

While some youth experiment with marijuana but don't go on to long-term use, others develop a problematic pot habit that continues into adulthood.

22 Mar 2021

Chaotic genetic changes drive the growth of melanomas

Melbourne researchers have revealed how melanoma cells are flooded with DNA changes as this skin cancer progresses from early, treatable stages through to fatal end-stage disease.

22 Mar 2021

Could nanoparticle vaccines offer broad protection against sarbecoviruses?

To understand the ability of SARS-CoV-2 vaccine-elicited antibodies to neutralize and protect against emerging variants (that are pathogenic) and other sarbecoviruses, a large team of researchers studied immunity by receptor-binding domain nanoparticle vaccines. They showed that a clinical-stage multivalent SARS-CoV-2 receptor-binding domain nanoparticle vaccine (SARS-CoV-2 RBD-NP) protected mice from the SARS-CoV-2-induced disease.

22 Mar 2021

New study to identify prenatal and early childhood markers of high risk for food allergy and eczema

A study to identify prenatal and early childhood markers of high risk for food allergy and atopic dermatitis, or eczema, as well as biological pathways that lead to these conditions, has begun.

22 Mar 2021

Blocking folate metabolism could reduce SARS-CoV-2 viral replication in infected cells

The novel beta-coronavirus virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and coronaviruses, in general, alter the host's cellular metabolism to support massive production of ~30 kB viral genomes and subgenomic viral RNAs. However, how this is achieved is largely unknown.

21 Mar 2021

Joint project aims to establish automated system for SARS-CoV-2 analysis in wastewater

On March 19, 2021, Hokkaido University, Robotic Biology Institute Inc., iLAC Co., Ltd., and Shionogi & Co., Ltd. have entered into a memorandum of understanding (MOU) toward the establishment of an automated system for the analysis of the novel coronavirus (SARS-CoV-2) in wastewater.

20 Mar 2021

Genome News and Research

Deep learning tool predicts hosts based on early SARS-CoV-2 samples

Researchers examine acriflavine's antiviral potential against SARS-CoV-2

Modeling study predicts SARS-CoV-2 variants with high receptor binding affinity

High throughput screening for COVID-19 with the VOYAGER pipette

CureVac's COVID-19 vaccine protects mice against emerging SARS-CoV-2 variants

Over-expression of LRRN4CL gene linked to metastasis of certain cancers to the lungs

Researchers use new approach to detect COVID-19 in wastewater

Researchers use new approach to detect COVID-19 in wastewater

Simple SARS-CoV-2 mutations allow escape from the majority of polyclonal antibodies

Virginia Tech neuroscientist uses NIH grant to understand astrocytic processes in the healthy brain

Anti-androgen drugs may help disarm coronavirus spike protein, stop progression of COVID-19

Inherited behaviors, traits that appear during adolescence may be related to adult cannabis use

Chaotic genetic changes drive the growth of melanomas

Could nanoparticle vaccines offer broad protection against sarbecoviruses?

New study to identify prenatal and early childhood markers of high risk for food allergy and eczema

Blocking folate metabolism could reduce SARS-CoV-2 viral replication in infected cells

Joint project aims to establish automated system for SARS-CoV-2 analysis in wastewater

Newly discovered enzyme on deadly fungus may be the key to fight fungal infection

Underrepresentation in genomic databases may affect therapy selection for minority patients

Developing a COVID-19 vaccine using inactivated E. coli

The art of CRISPR: The power and promise of gene editing eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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