Clinical Trial News and Research

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Cavity shave margin resection reduces the rate of positive margins in patients with DCIS

According to the American Cancer Society, a noninvasive breast cancer called ductal carcinoma in situ (DCIS) accounts for approximately one of every four new breast cancer cases in the United States.

5 Apr 2021

Phase 1 clinical study of unique vaccine to protect against COVID-19 begins

A unique vaccine to protect against COVID-19 begins clinical testing Tuesday, 6 April, at the Walter Reed Army Institute of Research (WRAIR), part of the U.S. Army Medical Research and Development Command.

5 Apr 2021

Chemical inhibitor can reduce SARS-CoV-2's ability to infect host cell lines

James McKerrow, MD, PhD, dean of the Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego, has long studied neglected tropical diseases -- chronic and disabling parasitic infections that primarily affect poor and underserved communities in developing nations.

3 Apr 2021

Study investigates the efficacy of COVID-19 vaccines over longer term

COVID-19 vaccines were designed to reduce the likelihood that infection by the SARS-CoV-2 virus would lead to severe outcomes, such as hospitalization and death. In that sense, all of the currently approved vaccines -- Moderna, Pfizer and Johnson & Johnson -- have proven comparably effective.

2 Apr 2021

New wireless system can restore communication and mobility in people with paralysis

Brain-computer interfaces (BCIs) are an emerging assistive technology, enabling people with paralysis to type on computer screens or manipulate robotic prostheses just by thinking about moving their own bodies.

2 Apr 2021

Changing diet and exercise can make chemotherapy more effective in youth with leukemia

Overweight children and adolescents receiving chemotherapy for treatment of leukemia are less successful battling the disease compared to their lean peers.

1 Apr 2021

Stem cell transplants offer long-term benefits for pediatric cancer patients receiving immunotherapy

Children and young adults who receive CAR T-cell therapy for the most common childhood cancer - acute lymphoblastic leukemia - suffer remarkably fewer relapses and are far more likely to survive when the treatment is paired with a subsequent stem cell transplant, a new study finds.

1 Apr 2021

Single injection of RNA therapy improves vision in patient with genetic form of childhood blindness

A Penn Medicine patient with a genetic form of childhood blindness gained vision, which lasted more than a year, after receiving a single injection of an experimental RNA therapy into the eye.

1 Apr 2021

Modest dietary changes and exercise can improve survival outcomes for young people with leukemia

In some cancers, including leukemia in children and adolescents, obesity can negatively affect survival outcomes. Obese young people with leukemia are 50% more likely to relapse after treatment than their lean counterparts.

1 Apr 2021

Giving chemotherapy in the morning can extend survival of glioblastoma patients

An aggressive type of brain cancer, glioblastoma has no cure. Patients survive an average of 15 months after diagnosis, with fewer than 10% of patients surviving longer than five years.

31 Mar 2021

Risk of SARS-CoV-2 from reinfected individuals with previous infection or vaccination

A technical report recently published by the European Center for Disease Prevention and Control (ECDC) has summarized all available literature regarding the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission from asymptomatic reinfected individuals with a history of SARS-CoV-2 infection or vaccination.

31 Mar 2021

New Phase 1 clinical trial of investigational vaccine against B.1.351 SARS-CoV-2 variant begins

An investigational vaccine designed to protect against the B.1.351 SARS-CoV-2 variant has been administered as part of a new Phase 1 clinical trial evaluating the vaccine candidate's safety and immunogenicity in adult volunteers.

31 Mar 2021

Gene therapy restores vison in dogs with severe form of Leber congenital amaurosis

Gustavo Aguirre and William Beltran, veterinary ophthalmologists and vision scientists at the University of Pennsylvania School of Veterinary Medicine, have studied a wide range of different retinal blinding disorders.

31 Mar 2021

Widely available drug reduces morbidity, mortality in COVID-19-infected mice

Mount Sinai researchers have found that a widely available and inexpensive drug targeting inflammatory genes has reduced morbidity and mortality in mice infected with SARS-CoV-2, the virus that causes COVID-19.

31 Mar 2021

Combination of two existing drugs can kill cancer cells

Preclinical research from VCU Massey Cancer Center published recently in the Proceedings of the National Academy of Sciences shows that the combination of two existing drugs can exploit the metabolic "hunger" of a particularly aggressive type of neuroblastoma to kill cancer cells without inflicting too much collateral damage to healthy tissue.

31 Mar 2021

Study compares performance of open-label placebo to blinded placebo in IBS patients

For decades, the power of the placebo effect was thought to lie in patients' belief that they were -- or at least, could be -- receiving a pharmacologically active treatment.

30 Mar 2021

Scientists launch clinical trial of CRISPR gene correction therapy in patients with sickle cell disease

Scientists at UC San Francisco, UC Berkeley and UCLA have received U.S. Food and Drug Administration approval to jointly launch an early phase, first-in-human clinical trial of a CRISPR gene correction therapy in patients with sickle cell disease using the patient's own blood-forming stem cells.

30 Mar 2021

Clinical Trial News and Research

Cavity shave margin resection reduces the rate of positive margins in patients with DCIS

Phase 1 clinical study of unique vaccine to protect against COVID-19 begins

Chemical inhibitor can reduce SARS-CoV-2's ability to infect host cell lines

Study investigates the efficacy of COVID-19 vaccines over longer term

New wireless system can restore communication and mobility in people with paralysis

Changing diet and exercise can make chemotherapy more effective in youth with leukemia

Stem cell transplants offer long-term benefits for pediatric cancer patients receiving immunotherapy

Single injection of RNA therapy improves vision in patient with genetic form of childhood blindness

Modest dietary changes and exercise can improve survival outcomes for young people with leukemia

Giving chemotherapy in the morning can extend survival of glioblastoma patients

Risk of SARS-CoV-2 from reinfected individuals with previous infection or vaccination

New Phase 1 clinical trial of investigational vaccine against B.1.351 SARS-CoV-2 variant begins

Gene therapy restores vison in dogs with severe form of Leber congenital amaurosis

Widely available drug reduces morbidity, mortality in COVID-19-infected mice

Combination of two existing drugs can kill cancer cells

Study compares performance of open-label placebo to blinded placebo in IBS patients

Scientists launch clinical trial of CRISPR gene correction therapy in patients with sickle cell disease

The Dream Team opens clinical trial to find better treatment options for pancreatic cancer

Research consortium identifies cell stress mechanisms for chronic inflammatory liver disease

Researchers develop broadly neutralizing SARS-CoV-2 ferritin nanoparticle vaccine

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