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Diverse patient population helps identify gene variant associated with childhood asthma

Researchers at Henry Ford Health System, as part of a national asthma collaborative, have identified a gene variant associated with childhood asthma that underscores the importance of including diverse patient populations in research studies.

27 Feb 2021

Atherosclerosis can speed up the development of clonal hematopoiesis

Billions of peripheral white blood cells are produced every day by the regular divisions of hematopoietic stem cells and their descendants in the bone marrow.

27 Feb 2021

Study: Heart problems cause disturbed gene activity in the brain's memory center

Heart problems cause disturbed gene activity in the brain's memory center, from which cognitive deficits arise.

27 Feb 2021

OHSU study represents a new milestone in the field of precision medicine

Researchers at Oregon Health & Science University have demonstrated a new method of quickly mapping the genome of single cells, while also clarifying the spatial position of the cells within the body.

26 Feb 2021

Retroviruses invading the koala germline contribute to high cancer rates

Koalas are facing multiple environmental and health issues which threaten their survival. Along with habitat loss - accelerated by last year’s devastating bush fires – domestic dog attacks and road accidents, they suffer from deadly chlamydial infections and extremely high frequency of cancer.

26 Feb 2021

Single dose of Pfizer BioNTech vaccine can reduce asymptomatic SARS-CoV-2 infections

New data from Addenbrooke's Hospital in Cambridge suggests that a single dose of the Pfizer BioNTech vaccine can reduce by four-fold the number of asymptomatic SARS-CoV-2 infections.

26 Feb 2021

Study describes the sequencing of 64 full human genomes

Researchers at the University of Maryland School of Medicine (UMSOM) co-authored a study, published today in the journal Science, that details the sequencing of 64 full human genomes.

26 Feb 2021

Study explains the evolution of SARS-CoV-2 virus

As COVID-19 sweeps the world, related viruses quietly circulate among wild animals. A new study shows how SARS-CoV-2, the virus that causes COVID-19, and SARS-CoV-1, which caused the 2003 SARS outbreak, are related to each other.

26 Feb 2021

Scientists receive grant to investigate tumor development within a natural environment

Unlike many of us during the COVID-19 pandemic, biological cells are not isolated from the outside world. Chemical variations, intercellular activity, and other microenvironmental factors impact cell survival.

25 Feb 2021

CRISPR screen identifies clinically approved immunosuppressants that could treat coronavirus infections

Researchers in Switzerland and Germany have identified host cell factors required for coronavirus replication that could serve as targets for treatment with clinically-approved drugs.

25 Feb 2021

World-leading research institutions join forces to find better treatments for pediatric diseases

Ahead of Rare Disease Day (28 February), four leading children's research institutions on three continents are joining forces to decipher pediatric illnesses, including rare diseases, and find better treatments.

25 Feb 2021

FDA approval provides targeted treatment option for patients with rare DMD mutation

Today, the U.S. Food and Drug Administration granted approval for Amondys 45 (casimersen) injection for the treatment of Duchenne muscular dystrophy (DMD) in patients who have a confirmed mutation of the DMD gene that is amenable to exon 45 skipping (Exons are pieces of DNA that provide information for making proteins in a person's genome).

25 Feb 2021

SARS-CoV-2 ORF7a mutation limits host immune suppression, finds study

Researchers have identified a high variability in the C-terminal end of ORF7a in SARS-CoV-2 sequences collected from around the globe. They noted that mutations result in a defective suppression of interferon and lowered replication rate.

25 Feb 2021

Have a case of a Covid variant? No one is going to tell you

Covid-19 infections from variant strains are quickly spreading across the U.S., but there's one big problem: Lab officials say they can't tell patients or their doctors whether someone has been infected by a variant.

25 Feb 2021

Study explores individual differences of SARS-CoV-2 infection in ACE2-expressing stem cells

The clinical phenotype of COVID-19, caused by SARS-CoV-2, is remarkable for its wide range of severity among individual patients. Genetic variations are known to mediate part of these differences. To examine these differences, researchers in a new study used human induced pluripotent stem cells (iPSCs) from different genetically diverse individuals. These cells are used to model genetic disease since they contain the donor’s genetic information. Researchers use a panel of iPSCs from over 500 individuals. The researchers preferred undifferentiated iPSCs to reduce the time required to differentiate them, especially since infection is not always reliable.

25 Feb 2021

Study provides new insight into the genetics of coronary artery disease

According to a new study published in The American Journal of Human Genetics, more than one third of genetic variants that increase the risk of coronary artery disease regulate the expression of genes in the liver. These variants have an impact on the expression of genes regulating cholesterol metabolism, among other things.

25 Feb 2021

Genome News and Research

Diverse patient population helps identify gene variant associated with childhood asthma

Atherosclerosis can speed up the development of clonal hematopoiesis

Study: Heart problems cause disturbed gene activity in the brain's memory center

OHSU study represents a new milestone in the field of precision medicine

Retroviruses invading the koala germline contribute to high cancer rates

Single dose of Pfizer BioNTech vaccine can reduce asymptomatic SARS-CoV-2 infections

Study describes the sequencing of 64 full human genomes

Study explains the evolution of SARS-CoV-2 virus

Scientists receive grant to investigate tumor development within a natural environment

CRISPR screen identifies clinically approved immunosuppressants that could treat coronavirus infections

World-leading research institutions join forces to find better treatments for pediatric diseases

FDA approval provides targeted treatment option for patients with rare DMD mutation

SARS-CoV-2 ORF7a mutation limits host immune suppression, finds study

Have a case of a Covid variant? No one is going to tell you

Study explores individual differences of SARS-CoV-2 infection in ACE2-expressing stem cells

Study provides new insight into the genetics of coronary artery disease

'Miracle poison' can target a variety of different proteins

KTH researchers identify 300 proteins that regulate cell division process

Travelers to the tropics are more prone to acquiring superbacteria than previously thought

High-throughput genetic analysis can help dissect the mechanism of disease inheritance

The art of CRISPR: The power and promise of gene editing eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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