Receptor News and Research

RSS

Mutational landscape of SARS-CoV-2 Omicron variant

New research suggests mutations on the receptor-binding domain of the Omicron variant exert indirect effects that reduce antibody binding to epitopes and promote immune evasion.

10 Dec 2021

Impact of mRNA-1273 vaccination during early pregnancy

Researchers from Yale University School of Medicine found that vaccination during the first trimester does not produce congenital disabilities or size abnormalities.

10 Dec 2021

Research suggests targeting fusion peptide-calcium interaction may help treat COVID-19

Researchers discovered that the entry of coronaviruses is a Ca2+-dependent process and focused their studies on the SARS-1 FP-Ca2+ interaction and its effect on membranes using electron spin resonance (ESR).

10 Dec 2021

Study finds sarbecoviruses circulating in wildlife outside Asia can infect human cells

A recent study tested the RBD of 2 sarbecoviruses found in Russian horseshoe bats and other clades 3 viruses for their ability to invade the human cell.

10 Dec 2021

Neutralizing antibody response against SARS-CoV-2 variants in health care workers pre- and post-vaccination

Researchers examined neutralizing antibody levels in 48 vaccinated health care workers against the major SARS-CoV-2 variants.

10 Dec 2021

Analysis finds substantially more mutations in the omicron SARS-CoV-2 variant

A University of Florida Health researcher has successfully analyzed the many mutations in the omicron variant of the SARS-CoV-2 virus, a crucial step in better understanding the variant's potential threat and ways to combat it.

9 Dec 2021

SARS-CoV-2 Omicron variant may bind with ACE2 receptor more efficiently

A new study discusses the effect of the Omicron variant’s mutations on its binding efficiency to the ACE2 receptor.

9 Dec 2021

Long term vaccine response following Pfizer COVID-19 vaccination in hemodialysis patients

Researchers discuss the long-term humoral immune responses in hemodialysis patients after being vaccinated with the BNT162b2 mRNA vaccine.

9 Dec 2021

Characterization of SARS-CoV-2 spike protein mutation with no associated increase in epidemiological fitness

Researchers from the Centro de Investigaciones Biológicas Margarita Salas have been investigating one of the mutations that typically appear in the Delta variant.

9 Dec 2021

Novel waveform-based approach to determine the propensity of betacoronaviruses to infect humans

Scientists attempt to understand the evolution of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2.

9 Dec 2021

Study reveals the role of intracellular receptor PQBP1 in response to Tau protein

Just as a home security system can alert a homeowner to the presence of an intruder, a protein called polyglutamine binding protein-1 (PQBP1) found in brain cells can alert the body to the presence of "intruding" viruses like human immunodeficiency virus (HIV).

9 Dec 2021

Kinetics and persistence of SARS-CoV-2 antibody responses

New study findings indicate that antibody detection shows a distinct pattern depending on the type of antibody detected, the target antigen, the test design, antibody avidity level, and COVID-19 severity.

9 Dec 2021

Gene therapy and diabetes drug may be treatments for late-onset retinal degeneration

Scientists have discovered that gene therapy and the diabetes drug metformin may be potential treatments for late-onset retinal degeneration (L-ORD), a rare, blinding eye disease.

9 Dec 2021

Effect of SARS-CoV-2 variant emergence on efficacy of neutralizing antibodies and vaccines

A review article focuses on the efficacy of neutralizing antibodies and vaccines against the SARS-CoV-2 variants.

9 Dec 2021

Glycans strengthen and lengthen SARS-Cov-2 spike binding to ACE2

New study results provide evidence that the binding between SARS-CoV-2 RBD and host ACE2 receptor is aided by the glycosylation on each protein.

9 Dec 2021

Immunogenicity and safety of COVID-19 subunit vaccine Nanocovax in animal models

Researchers have developed Nanocovax, a COVID-19 subunit vaccine based on recombinant protein technology to produce the extracellular (soluble) portion of the S protein of SARS-CoV-2.

9 Dec 2021

UVA researchers uncover common link between lupus and macular degeneration

University of Virginia School of Medicine researchers have made a discovery linking lupus, a potentially debilitating autoimmune disorder, and macular degeneration, a leading cause of blindness.

9 Dec 2021

Sugar-binding pockets in N-terminal domain may increase SARS-CoV-2 infectivity

The N-terminal domain has a fold that can bind sugar, and new research led by Jonathan Lees from Oxford Brookes University found the sugar-binding pockets near the N-terminal domain help to increase viral infectivity. Furthermore, the findings show that the SARS-CoV-2 sugar-binding pockets are evolving with added loops observed in the pockets of new variants.

9 Dec 2021

SARS-CoV-2 variants are evolving new ways to evade antibodies and vaccines

Continued replication of severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2) under selective pressure from natural and vaccine-induced immunity has led to the emergence of variants of concern (VOCs) with increased transmissibility or virulence.

8 Dec 2021

Neutralization antibodies elevated in nursing home residents after COVID-19 mRNA boosters

Researchers from the United States, in their recent study published on the preprint server medRxiv*, have evaluated the humoral responses to third vaccine dose in nursing home residents and healthcare workers (HCW) and found that that second booster (or third vaccine dose) significantly increased anti-spike, anti-receptor binding domain (RBD), and neutralization titers in almost all nursing home residents and HCW to considerably higher levels than what was attained after the completion of the initial two-dose vaccine series.

8 Dec 2021

Receptor News and Research

Mutational landscape of SARS-CoV-2 Omicron variant

Impact of mRNA-1273 vaccination during early pregnancy

Research suggests targeting fusion peptide-calcium interaction may help treat COVID-19

Study finds sarbecoviruses circulating in wildlife outside Asia can infect human cells

Neutralizing antibody response against SARS-CoV-2 variants in health care workers pre- and post-vaccination

Analysis finds substantially more mutations in the omicron SARS-CoV-2 variant

SARS-CoV-2 Omicron variant may bind with ACE2 receptor more efficiently

Long term vaccine response following Pfizer COVID-19 vaccination in hemodialysis patients

Characterization of SARS-CoV-2 spike protein mutation with no associated increase in epidemiological fitness

Novel waveform-based approach to determine the propensity of betacoronaviruses to infect humans

Study reveals the role of intracellular receptor PQBP1 in response to Tau protein

Kinetics and persistence of SARS-CoV-2 antibody responses

Gene therapy and diabetes drug may be treatments for late-onset retinal degeneration

Effect of SARS-CoV-2 variant emergence on efficacy of neutralizing antibodies and vaccines

Glycans strengthen and lengthen SARS-Cov-2 spike binding to ACE2

Immunogenicity and safety of COVID-19 subunit vaccine Nanocovax in animal models

UVA researchers uncover common link between lupus and macular degeneration

Sugar-binding pockets in N-terminal domain may increase SARS-CoV-2 infectivity

SARS-CoV-2 variants are evolving new ways to evade antibodies and vaccines

Neutralization antibodies elevated in nursing home residents after COVID-19 mRNA boosters

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Latest News