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Potential drug to annul ADAM-17 protein activity needed

Over the past four years, in the installations of the Faculty of Medicine, University of Cadiz, a group of researchers, headed by Doctor Carmen Estrada, has been studying neurogenesis - the process of forming new neurons from mother cells - in the adult mammal brain. The purpose of this research project is to contribute to the knowledge of this process with the object of finding some additional mechanism that would facilitate the treatment of pathologies of the central nervous system (CNS) that are suffered in consequence of neuronal death.

19 Apr 2010

New p53 knockout rat model improves timelines for carcinogenicity screening

Sigma Life Science, the innovative biological products and services brand of Sigma-Aldrich, today introduced the world's first p53 'knockout' rat model, an important development that is expected to, due to the rat's closer physiological and metabolic similarity to humans, significantly improve timelines for carcinogenicity screening and reduce time to market for therapeutics.

19 Apr 2010

Organogenesis to showcase study results of Apligraf product at SAWC / WHS 2010

Organogenesis, Inc. will have a substantial presence at the 23rd Annual Symposium on Advanced Wound Care and Wound Healing Society being held April 17-20 in Orlando, FL. Results from several clinical and scientific studies will be presented which will further the understanding of Organogenesis' bilayered living cellular construct technology.

19 Apr 2010

Enhancing drug residence time may help develop better diagnostic, therapeutic agents

Research conducted at the Stony Brook University Institute for Chemical Biology & Drug Discovery that enhances the time a drug remains bound to its target, or residence time, may prove to be an important step in developing better diagnostic and therapeutic agents based partly on longer drug residence time.

17 Apr 2010

MedImmune to present ten abstracts at American Association for Cancer Research meeting

MedImmune today announced that ten abstracts on progress being made in various oncology programs will be presented during the Annual Meeting of the American Association for Cancer Research in Washington, DC from April 17 to 21.

17 Apr 2010

Endra Life Sciences launches Nexus 128 preclinical photoacoustic CT scanner

Endra Life Sciences today announced the launch of the Nexus 128, a preclinical photoacoustic computed tomography (CT) scanner for small animal imaging. The system is used for simple, fast, non-invasive quantification of tumor vasculature and other physiological parameters for preclinical research.

16 Apr 2010

New therapeutic approach for Duchenne muscular dystrophy

Researchers from Universit- Laval's Faculty of Medicine and the CHUQ Research Center have proven that it is possible to repair the defective gene responsible for Duchenne muscular dystrophy.

16 Apr 2010

Stemgent, Pfizer announce collaboration and research licensing agreement

Stemgent, Inc. and Pfizer Inc. today announced a collaboration and research licensing agreement that will lead to certain research reagents developed or discovered by Pfizer being made available to the global research community through Stemgent. Stemgent provides research tools and services to institutions, companies and universities in advancing in vitro and in vivo non-human stem cell research.

16 Apr 2010

Regulus Therapeutics' metabolic disease program data presented at Diabetes Keystone Symposium

Regulus Therapeutics Inc. today announced that new data from its metabolic disease program were presented at the "Diabetes" Keystone Symposium held April 12-17 in Whistler, British Columbia. The new pre-clinical research findings showed that therapeutic oligonucleotides targeting microRNA are able to improve insulin resistance and normalize plasma glucose in mouse models of diabetes while having no significant effect on glucose or insulin levels in normal mice.

16 Apr 2010

Brain regions play a fundamental role in empathetic and violent situations

"Just as our species could be considered the most violent, since we are capable of serial killings, genocide and other atrocities, we are also the most empathetic species, which would seem to be the other side of the coin", Luis Moya Albiol, lead author of the study and a researcher at the UV, tells SINC.

15 Apr 2010

PSI acquires PEG-based technology

Particle Sciences Inc. (PSI), a leading pharmaceutical CRO, is adding to its portfolio of drug delivery technologies through the acquisition of a versatile PEG-based technology. The technology covers a series of PEG-grafted cationic polymers that have a wide variety of applications in the pharmaceutical arena.

15 Apr 2010

TD2, Horizon Discovery announce strategic alliance to advance personalized medicine

A strategic alliance announced today between TGen Drug Development (TD2) and Horizon Discovery Limited will significant advance personalized medicine.

13 Apr 2010

Carestream Molecular Imaging, OncoVision sign exclusive agreement for Albira PET/SPECT/CT imaging system

Carestream Molecular Imaging, a division of Carestream Health, Inc., has signed an exclusive, multi-year worldwide agreement with OncoVision (Valencia, Spain), to sell, market and service the Albira PET/SPECT/CT imaging system for small animal research. With the addition of this innovative, multimodal imaging system, Carestream Molecular Imaging will offer the broadest portfolio of pre-clinical in vivo imaging modalities in the market.

12 Apr 2010

Cempra to make poster presentations on CEM-101 and CEM-102 at ECCMID 2010

Cempra Pharmaceuticals today announced poster presentations on its novel antibiotic CEM-101, a next-generation macrolide, and CEM-102, the company's proprietary front-loading oral dosing regimen of sodium fusidate, at the 20th European Congress of Clinical Microbiology and Infectious Disease, April 10 to 13, 2010, in Vienna Austria.

12 Apr 2010

Fate Therapeutics to acquire Ottawa biotechnology company Verio Therapeutics

Fate Therapeutics, Inc. announced today a definitive agreement to acquire Verio Therapeutics Inc., a privately held biotechnology company based in Ottawa, Ontario, which is developing drug candidates targeting the activation of endogenous stem cells. Verio Therapeutics is advancing the work of several of Canada's leading stem cell scientists, including Michael Rudnicki, Ph.D., FRSC, and Lynn Arthur Megeney, Ph.D., who have made breakthrough discoveries relating to muscle and pancreatic regeneration.

9 Apr 2010

Enrollment completes for Inovio Biomedical's dose escalation phase I trial of cervical cancer vaccine

Inovio Biomedical Corporation, a leader in DNA vaccine design, development and delivery, announced today that the company has completed enrollment of all subjects for its therapeutic cervical cancer vaccine (VGX-3100) phase I trial. VGX-3100 is a DNA vaccine targeting the E6 and E7 proteins of human papillomavirus (HPV) types 16 and 18, and is delivered via in vivo electroporation.

8 Apr 2010

CAV1 gene variation contributes to kidney transplant failure: JAMA

Among kidney transplant donors, variation of a gene that is an inhibitor of the development of fibrous connective tissue is significantly associated with an increased risk of graft failure, according to a study in the April 7 issue of JAMA.

7 Apr 2010

RXi Pharmaceuticals, TransDerm collaborate on study of RXi's proprietary compounds in dermatology applications

RXi Pharmaceuticals Corporation, a biopharmaceutical company pursuing the development and commercialization of proprietary therapeutics based on RNA interference (RNAi), and TransDerm, Inc., a biopharmaceutical company developing nucleic acid skin delivery technologies and therapeutics for skin disorders, announced today that they will collaborate on studying the potential utility of RXi's proprietary compounds in dermatology models.

7 Apr 2010

Src can be most promising targets for cancer therapy

Src (short for sarcoma) is a family of proto-oncogenic tyrosine kinases active in many cancer tumors, including medulloblastoma, the most common malignant cancer in children. Src represents one of the most promising targets for cancer therapy.

6 Apr 2010

FDA-approved contrast agent improves optical imaging of stem cells

A study published in the current issue of Cell Transplantation (19:1) has found that using the FDA-approved contrast agent Indocyanine Green (ICG) to label human embryonic stem cell-derived cardiomyocytes (hESC-CMs) substantially improved efforts to optically track stem cells after transplanting them into heart tissues.

6 Apr 2010

in vivo News and Research

Potential drug to annul ADAM-17 protein activity needed

New p53 knockout rat model improves timelines for carcinogenicity screening

Organogenesis to showcase study results of Apligraf product at SAWC / WHS 2010

Enhancing drug residence time may help develop better diagnostic, therapeutic agents

MedImmune to present ten abstracts at American Association for Cancer Research meeting

Endra Life Sciences launches Nexus 128 preclinical photoacoustic CT scanner

New therapeutic approach for Duchenne muscular dystrophy

Stemgent, Pfizer announce collaboration and research licensing agreement

Regulus Therapeutics' metabolic disease program data presented at Diabetes Keystone Symposium

Brain regions play a fundamental role in empathetic and violent situations

PSI acquires PEG-based technology

TD2, Horizon Discovery announce strategic alliance to advance personalized medicine

Carestream Molecular Imaging, OncoVision sign exclusive agreement for Albira PET/SPECT/CT imaging system

Cempra to make poster presentations on CEM-101 and CEM-102 at ECCMID 2010

Fate Therapeutics to acquire Ottawa biotechnology company Verio Therapeutics

Enrollment completes for Inovio Biomedical's dose escalation phase I trial of cervical cancer vaccine

CAV1 gene variation contributes to kidney transplant failure: JAMA

RXi Pharmaceuticals, TransDerm collaborate on study of RXi's proprietary compounds in dermatology applications

Src can be most promising targets for cancer therapy

FDA-approved contrast agent improves optical imaging of stem cells

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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