Endra Life Sciences launches Nexus 128 preclinical photoacoustic CT scanner

NewsGuard 100/100 Score

Endra Life Sciences today announced the launch of the Nexus 128, a preclinical photoacoustic computed tomography (CT) scanner for small animal imaging.  The system is used for simple, fast, non-invasive quantification of tumor vasculature and other physiological parameters for preclinical research.   The Nexus 128 makes in vivo quantification of tumor vasculature possible without the need for contrast agents and helps preclinical researchers gain deeper insight into areas such as how drugs treat disease and cancer progression, without ionizing radiation or complicated equipment.

Endra Life Sciences was founded by Enlight Biosciences, a funding syndicate of six of the world's leading pharmaceutical companies focused on commercializing transformational technologies. 

"Photoacoustic imaging combines ultrasound with the rich contrast of optical imaging, based on the same principles that give cells, organs, and tissues their unique colors,"  said Michael Thornton, Endra's President and Chief Operating Officer.   "It provides high spatial resolution at depth far exceeding that of conventional optical imaging techniques such as fluorescence and bioluminescence. We are excited to make this technology widely available to cancer biology researchers for the first time."

"Mouse models of cancer are used extensively to study tumor development and the effects of new therapies, but until now the tools to measure this effect have had depth limitations," said Dr. Rakesh Jain,  Director, Edwin L. Steele Laboratory for Tumor Biology at Harvard Medical School, and Enlight Biosciences Advisor.  "The ability to track abnormal vessel growth and normalization in vivo with high resolution throughout a tumor mass during therapeutic intervention is a powerful new capability that will be widely used in cancer research." 

The name Nexus 128 represents the convergence of light and sound in a powerful new imaging approach.  It employs a detector array consisting of 128 individual acoustic receiver elements arranged in a patented geometry.  The system generates multispectral, quantitative, three dimensional images of tumor vasculature and hemoglobin concentration in under 2 minutes, and completes volumetric anatomical scans in as little as 12 seconds.  "For the past several years, our research group has developed quantitative photoacoustic spectroscopy imaging techniques and applied them to mouse models of cancer," said Dr. Keith Stantz, faculty member of Purdue University.  "We have been using Endra's photoacoustic tomography prototype system regularly for the past year.  The simplified animal handling and high throughput allow us to image entire study groups within a couple of hours."


Endra Life Sciences


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Ultrahigh-spatial-resolution PCD-CT improves assessment of coronary artery disease