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New technique could lead to more effective therapies for AIDS

When researchers came up with the powerful cocktail of anti-HIV drugs known as highly active antiretroviral therapy (HAART), they hoped they had found a way to finally rid the body of the virus. But they were wrong.

4 Jan 2005

Elementary school intervention boosts positive functioning in early childhood

An elementary school intervention program that taught children impulse control and gave their teachers and parents better management skills has long-lasting effects extending into early adulthood, showing that the children are more productive and well-adjusted members of society at age 21, according to a new study.

4 Jan 2005

Calcium intake contributing factor in formation of kidney stones

Individuals with either calcium oxalate or calcium phosphate kidney stones should not take extra calcium on their own as suggested by previous research, but should check with their doctors to determine the dietary guidelines that work best for them, researchers at UT Southwestern Medical Center at Dallas have found.

4 Jan 2005

Technology that could double the effectiveness of cancer drugs

To identify the best treatment for recurrent ovarian cancer, researchers at Yale School of Medicine are studying a technology called the Yale apoptosis assay in combination with another technology called the ChemoFX assay, which could double the response rate to existing drugs.

4 Jan 2005

Genaissance patent for novel methods to correlate genetics with drug safety and efficacy

Genaissance Pharmaceuticals received a Notice of Allowance from the United States Patent and Trademark Office for a patent claiming methods for identifying correlations between the safety and efficacy of drugs and patients' unique genetic signatures.

4 Jan 2005

Genomics tools provide clues to what causes 400 million cases of gastrointestinal disease each year

In a study that could benefit medical and food-safety research, scientists have used comparative genomics tools to find clues about why some strains of the bacterium Campylobacter – which each year cause more than 400 million cases of gastrointestinal disease – are more virulent than others.

4 Jan 2005

Multi-state urinary tract infections likely caused by consumption of a contaminated food product of animal origin

A multi-state outbreak of urinary tract infections caused by drug-resistant Escherichia coli was probably due to consumption of a contaminated food product of animal origin, such as meat or milk, according to an article in the Jan. 15 issue of Clinical Infectious Diseases.

4 Jan 2005

Chronic users NSAIDs have greater risk of bleeding and visible damage to their small intestine

According to a study published today in the American Gastroenterological Association (AGA) journal Clinical Gastroenterology and Hepatology, chronic users of non-steroidal anti-inflammatory drugs (NSAIDs) have an increased risk of bleeding and visible damage to their small intestine.

4 Jan 2005

Signaling molecule involved in osteoarthritis identified

Using naturally-occurring mutant mice with a defective collagen gene, scientists at Harvard have identified a signaling molecule involved in one of the most common causes of disability among the elderly in the United States, osteoarthritis.

4 Jan 2005

Chronic constipation is uncomfortable, but not dangerous

There are a lot of common myths about constipation treatment. An article in the January issue of The American Journal of Gastroenterology dispels those myths and clears numerous misconceptions regarding chronic constipation.

4 Jan 2005

The rise in over the counter drugs, why?

Switching of prescription drugs to over the counter availability is increasingly common, but what are the motives behind this trend, ask US researchers in this week's BMJ?

3 Jan 2005

Eli Lilly aware in the 1980s that fluoxetine had troubling side effects

The BMJ has turned over confidential drug company documents that went missing from a 10 year old murder case to the US Food and Drug Administration (FDA) for review.

3 Jan 2005

New painkiller was discovered in natural form in venomous snails in 1979

The natural form of Prialt – a new drug for severe pain approved this week by the U.S. Food and Drug Administration – was discovered at the University of Utah in 1979 by an incoming freshman studying toxins produced by cone snails.

30 Dec 2004

Pegaptanib (Macugen) is an effective treatment for neovascular age-related macular degeneration

Results from two concurrent, prospective, double-blind, multi-center clinical trials show that pegaptanib (Macugen), an anti-vascular endothelial growth factor therapy, is an effective treatment for neovascular age-related macular degeneration (AMD), according to a paper in the Dec. 30 issue of the New England Journal of Medicine. Macugen was approved by the Food and Drug Administration on Dec. 17.

30 Dec 2004

Moderate physical exercise can stave off metabolic syndrome in people age 55 to 75

Researchers at Johns Hopkins have determined that in people age 55 to 75, a moderate program of physical exercise can significantly offset the potentially deadly mix of risk factors for heart disease and diabetes known as the metabolic syndrome.

30 Dec 2004

Is open source the answer for finding cures for tropical diseases?

Only about 1% of newly developed drugs are for tropical diseases, such as African sleeping sickness and dengue fever. While patent incentives have driven commercial pharmaceutical companies to make Western health care the envy of the world, the commercial model only works if companies can sell enough patented products to cover their R&D costs and produce profits for shareholders.

28 Dec 2004

Information submitted via new drug applications could easily be made accessible to the public

A researcher at Oregon Health & Science University and the Portland Veterans Affairs Medical Center is calling upon the U.S. Food and Drug Administration (FDA) to share more information provided by pharmaceutical companies regarding their clinical drug trials.

28 Dec 2004

Indian curry may be the next Alzheimer's weapon

A dietary staple of India, where Alzheimer's disease rates are reportedly among the world's lowest, holds potential as a weapon in the fight against the disease.

28 Dec 2004

Lessons learned from troubles with COX-2 inhibitors

One of the nation’s leading cardiovascular medical researchers has issued a call for less aggressive direct-to-consumer advertising and better safety assurances of medications in a special article posted online by JAMA because of its relevance to the recent withdrawals and warning labels on the pain-relieving drugs known as COX-2 inhibitors.

28 Dec 2004

Speculoscopy directly after a Pap smear may detect more cervical lesions than the Pap test alone

Inspecting the cervix with a bright light technology called speculoscopy directly after a Pap smear may detect more cervical lesions than the Pap test alone, according to a new review of studies about the procedure.

28 Dec 2004

Drugs News and Research

New technique could lead to more effective therapies for AIDS

Elementary school intervention boosts positive functioning in early childhood

Calcium intake contributing factor in formation of kidney stones

Technology that could double the effectiveness of cancer drugs

Genaissance patent for novel methods to correlate genetics with drug safety and efficacy

Genomics tools provide clues to what causes 400 million cases of gastrointestinal disease each year

Multi-state urinary tract infections likely caused by consumption of a contaminated food product of animal origin

Chronic users NSAIDs have greater risk of bleeding and visible damage to their small intestine

Signaling molecule involved in osteoarthritis identified

Chronic constipation is uncomfortable, but not dangerous

The rise in over the counter drugs, why?

Eli Lilly aware in the 1980s that fluoxetine had troubling side effects

New painkiller was discovered in natural form in venomous snails in 1979

Pegaptanib (Macugen) is an effective treatment for neovascular age-related macular degeneration

Moderate physical exercise can stave off metabolic syndrome in people age 55 to 75

Is open source the answer for finding cures for tropical diseases?

Information submitted via new drug applications could easily be made accessible to the public

Indian curry may be the next Alzheimer's weapon

Lessons learned from troubles with COX-2 inhibitors

Speculoscopy directly after a Pap smear may detect more cervical lesions than the Pap test alone

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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