Clinical Trial News and Research

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New research project aims to treat patients with secondary brain damage

The Universities of Birmingham and Cambridge have launched a new research project aimed at discovering if selective P2X7 receptor blocker drugs can be repurposed to treat patients with secondary brain damage.

9 Mar 2021

Current vaccines and therapies may be less effective at neutralizing new SARS-CoV-2 variants

A new study of the U.K. and South Africa variants of SARS-CoV-2 predicts that current vaccines and certain monoclonal antibodies may be less effective at neutralizing these variants and that the new variants raise the specter that reinfections could be more likely.

8 Mar 2021

CAR T-cell therapy triples expected length of remission for relapsed multiple myeloma patients

A new type of CAR T-cell therapy more than triples the expected length of remission for multiple myeloma patients who have relapsed several times, according to an international clinical trial with UT Southwestern as the lead enrolling site.

8 Mar 2021

Clinical trial launched to test the effectiveness of mouthwash in reducing COVID-19 spread

Researchers at the University of North Carolina at Chapel Hill Adams School of Dentistry have launched a clinical trial to test whether mouthwash can reduce a person's risk of spreading coronavirus.

8 Mar 2021

FDA-approved drug has limited treatment efficacy for hypoactive sexual desire disorder

An independent analysis of the medical trials which formed the final basis of approval by the US Food and Drug Administration (FDA) strongly suggests the drug bremelanotide has very limited effectiveness as a treatment for hypoactive sexual desire disorder (HSDD) in women, and that trial participants preferred a placebo.

8 Mar 2021

New trend can widen racial disparities in patient enrollment in cancer clinical trials

For the drug approval process in the United States, investigators have been expanding clinical trials to sites outside the country.

8 Mar 2021

Survey identifies top factor for longevity in clinical research coordinator positions

Strong, collaborative relationships with principal investigators are a key factor of longevity in clinical research coordinator positions -- an essential, but increasingly transient job in executing treatment-advancing clinical trials, Vanderbilt University Medical Center researchers found.

5 Mar 2021

Study proposes a new, noninvasive way to detect kidney transplant rejection

Patients can spend up to six years waiting for a kidney transplant. Even when they do receive a transplant, up to 20 percent of patients will experience rejection.

5 Mar 2021

Research reveals gender disparities in COVID-19 clinical trial leadership

Less than one-third of COVID-19 clinical trials are led by women, which is half the proportion observed in non-COVID-19 trials, according to research led by Queen Mary University of London, University of St Andrews, Brigham and Women's Hospital and Harvard Medical School.

5 Mar 2021

ACTIV-3 clinical trial evaluating investigational COVID-19 therapies closes enrollment in two sub-studies

The ACTIV-3 clinical trial, which is evaluating the safety and efficacy of investigational therapeutics for COVID-19 in hospitalized patients, has closed enrollment in two sub-studies: one examining the investigational monoclonal antibody therapy VIR-7831, and another evaluating the investigational combination monoclonal antibody therapy containing BRII-196 and BRII-198.

5 Mar 2021

One dose of SARS-CoV-2 vaccine candidate boosts neutralizing antibody response in COVID-19 convalescents

A new study details the results from a single dose of the FINLAY FR 1A recombinant dimeric receptor-binding domain (RBD) base vaccine during a phase I clinical trial with 30 COVID-19 convalescents to test its capacity for boosting natural immunity.

5 Mar 2021

Experimental safety switch reduces severity of CAR-T immunotherapy-related side effects

UNC Lineberger Comprehensive Cancer Center researchers have successfully used an experimental safety switch, incorporated as part of a chimeric antigen receptor T-cell (CAR-T) therapy, a type of immunotherapy, to reduce the severity of treatment side effects that sometimes occur.

4 Mar 2021

AI-based method for repurposing existing drugs into potential treatments for Alzheimer's

New treatments for Alzheimer's disease are desperately needed, but numerous clinical trials of investigational drugs have failed to generate promising options.

4 Mar 2021

Intrapericardial injection provides a less invasive means of treating cardiac injury

Injecting hydrogels containing stem cell or exosome therapeutics directly into the pericardial cavity could be a less invasive, less costly, and more effective means of treating cardiac injury, according to new research from North Carolina State University and the University of North Carolina at Chapel Hill.

4 Mar 2021

Rapid point-of-care test used to diagnose respiratory infections can reduce antibiotic prescribing

A rapid microbiological point-of-care test to diagnose respiratory infections has proved popular with GPs and could reduce antibiotic prescribing in primary care, according to a National Institute for Health Research funded study by researchers at the Centre for Academic Primary Care, University of Bristol.

4 Mar 2021

UK public health authorities review early data on the effectiveness of Pfizer and AstraZeneca COVID-19 vaccines

A team of UK scientists has recently evaluated the effectiveness of the Pfizer (BNT162b2) and AstraZeneca (ChAdOx1) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The findings reveal that both vaccines are effective in significantly reducing SARS-CoV-2 infection in older adults and providing long-term protection.

3 Mar 2021

Delayed second dose strategy with mRNA vaccines may reduce COVID-19 mortality, say researchers

An interesting new preprint shows that even if countries are forced to delay the second dose of the current vaccines administered against SARS-CoV-2, to arrest the ongoing COVID-19 pandemic, the cumulative mortality would still fall significantly.

3 Mar 2021

Semaglutide drug also helps diabetic patients lose body weight, shows study

A drug approved for diabetes has now been shown to also help patients with diabetes lose on average 10 percent of their body weight, UT Southwestern reports in a landmark international study.

3 Mar 2021

Evonik partners with BioNTech to manufacture lipids for COVID-19 vaccine

Caused by SARS-CoV-2, the coronavirus disease 2019 (COVID-19) pandemic continues to spread across the globe.

From Evonik 2 Mar 2021

New injectable hydrogel could heal cardiac tissue after heart attack

Researchers at CÚRAM, the SFI Research Centre for Medical Devices based at National University of Ireland Galway, and BIOFORGE Lab, at the University of Valladolid in Spain, have developed an injectable hydrogel that could help repair and prevent further damage to the heart muscle after a heart attack.

2 Mar 2021

Clinical Trial News and Research

New research project aims to treat patients with secondary brain damage

Current vaccines and therapies may be less effective at neutralizing new SARS-CoV-2 variants

CAR T-cell therapy triples expected length of remission for relapsed multiple myeloma patients

Clinical trial launched to test the effectiveness of mouthwash in reducing COVID-19 spread

FDA-approved drug has limited treatment efficacy for hypoactive sexual desire disorder

New trend can widen racial disparities in patient enrollment in cancer clinical trials

Survey identifies top factor for longevity in clinical research coordinator positions

Study proposes a new, noninvasive way to detect kidney transplant rejection

Research reveals gender disparities in COVID-19 clinical trial leadership

ACTIV-3 clinical trial evaluating investigational COVID-19 therapies closes enrollment in two sub-studies

One dose of SARS-CoV-2 vaccine candidate boosts neutralizing antibody response in COVID-19 convalescents

Experimental safety switch reduces severity of CAR-T immunotherapy-related side effects

AI-based method for repurposing existing drugs into potential treatments for Alzheimer's

Intrapericardial injection provides a less invasive means of treating cardiac injury

Rapid point-of-care test used to diagnose respiratory infections can reduce antibiotic prescribing

UK public health authorities review early data on the effectiveness of Pfizer and AstraZeneca COVID-19 vaccines

Delayed second dose strategy with mRNA vaccines may reduce COVID-19 mortality, say researchers

Semaglutide drug also helps diabetic patients lose body weight, shows study

Evonik partners with BioNTech to manufacture lipids for COVID-19 vaccine

New injectable hydrogel could heal cardiac tissue after heart attack

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