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Risk of having a heart attack is elevated in the weeks after stopping use of nonsteroidal anti-inflammatory drugs

The risk of having a heart attack is elevated in the weeks after stopping use of nonsteroidal anti-inflammatory drugs, according to an article in the December issue of The Archives of Internal Medicine, one of the JAMA/Archives journals.

13 Dec 2004

Instead of chemotherapy, drugs that influence the X protein's behavior might become an alternative cancer therapy

Identifying the link between chronic hepatitis B infection and liver cancer may one day help cancer patients sidestep the poison of chemotherapy, a Purdue University study suggests.

13 Dec 2004

Link found between bisphosphonates and a serious bone disease called osteonecrosis of the jaw

Doctors at Long Island Jewish (LIJ) Medical Center recently discovered a link between a common chemotherapy drug and a serious bone disease called osteonecrosis of the jaw (ONJ).

13 Dec 2004

Celebrex like gene suppresses the growth of colon cancer

Cancer researchers at the Case Western Reserve University (Case) School of Medicine, University Hospitals of Cleveland (UHC) and the Howard Hughes Medical Institute have found a "Celebrex-like" gene that suppresses the growth of colon cancer.

13 Dec 2004

Successful human trial of obesity drug that mimicks metabolic effects of growth hormone

The AOD9604 molecule is a small orally active peptide modelled on one section of the human growth hormone molecule. Growth hormone naturally occurs in the body and has profound stimulatory effects on fat metabolism, with levels of the hormone typically becoming suppressed in the obese state.

13 Dec 2004

Compounds in Christmas trees could help treat arthritis and pain

Researchers have identified a group of anti-inflammatory compounds in the bark of the Scotch pine - widely used for Christmas trees - that they say could be developed into food supplements or drugs for treating arthritis and pain.

13 Dec 2004

Wiping out a protein in skin cancer cells could significantly stall melanoma tumor development

The protein, Akt3, appears to be responsible for promoting tumor cell survival and development in 43 percent to 60 percent of non-inherited melanomas.

13 Dec 2004

FDA accepts Genmab's Investigational New Drug Application for active rheumatoid arthritis treatment

Genmab announced today the US Food and Drug Administration (FDA) accepted its Investigational New Drug Application (IND) to start a Phase I/II dose escalation trial for HuMax-CD20 to treat patients with active rheumatoid arthritis (RA) who have failed one treatment with one or more disease modifying anti-rheumatic drugs (DMARDs).

13 Dec 2004

Findings could lead to new knowledge that could speed the development of drugs to block botulism or tetanus toxins more rapidly

The first detailed structure of a botulism toxin attached to its target protein reveals that the toxin snakes the protein around itself — a sort of “reverse anaconda” — to recognize the receptor.

13 Dec 2004

Computational model of addiction which can be used to make predictions about human behavior

A University of Minnesota researcher developed a computational model of addiction which can be used to make predictions about human behavior, animal behavior, and neurophysiology.

13 Dec 2004

Newly discovered genetic defect might represent an important risk factor for major depression

A newly discovered genetic defect might represent an important risk factor for major depression, a condition which effects 20 million people in the U.S., according to Duke University Medical Center researchers.

13 Dec 2004

Lupus drug may also be useful in treating psoriasis

A new drug candidate previously shown to reduce harmful side effects of the autoimmune disease lupus also may be useful in treating psoriasis.

13 Dec 2004

Novel anti-rejection protocol should allow major improvement efficacy and quality of life after intestinal and multivisceral transplants

Transplant researchers at the University of Pittsburgh's Thomas E. Starzl Transplantation Institute have dramatically improved intestinal transplant graft survival, and reduced rejection and infection rates by successfully using a novel immunosuppression minimization protocol, thus improving patients' overall quality of life and avoiding the use of several anti-rejection drugs, which can cause serious infections and major complications.

13 Dec 2004

Importance of the phosphatidylinositol 3 kinase (PI3K) pathway to breast cancer development

Because up to 75 percent of breast cancer patients have an abnormality in a specific cell signaling pathway, drugs that target different molecules along that pathway may be especially effective for treating the disease, says a researcher from The University of Texas M. D. Anderson Cancer Center.

13 Dec 2004

Study sheds light on how bacteria persist despite antibiotics

Researchers at the Hebrew University of Jerusalem and Rockefeller University in New York have demonstrated the constant presence of antibiotic-tolerant "persistent cells" within bacteria colonies and have shown, through mathematical modeling, how these cells develop into "normal" cells following their survival of even heavy dosages of antibiotics.

13 Dec 2004

Pharmaceutical, biotechnology and drug discovery companies are increasingly turning their attention to cell-based assays

Pharmaceutical, biotechnology and drug discovery companies are increasingly turning their attention to cell-based assays, as these assays offer a more accurate representation of the real-life cell model than the traditional enzyme- or antibody-based assays.

13 Dec 2004

Excellent news for the many people who suffer from high blood pressure

An international trial comparing blood-pressure lowering treatments has been stopped early due to the significantly better performance of one of the treatments in the trial.

8 Dec 2004

Wide angle X-ray scattering (WAXS) could help produce lead drugs for disease therapy

Structural changes in proteins can now be seen in increased detail, using a new application of an existing technique. The application, developed at the U.S. Department of Energy's Argonne National Laboratory, could help produce lead drugs for disease therapy.

8 Dec 2004

Need to correct racial disparities in health

The number of lives saved by medical advances over the last 10 years is far outdistanced by the number of lives lost to racial disparities in health status, according to a Virginia Commonwealth University family medicine and public health physician.

8 Dec 2004

Greater risk of heart attack associated with Vioxx than Celebrex

In the first epidemiological study designed and executed specifically to determine the heart-attack risk associated with COX-2 inhibitors rofecoxib (Vioxx) and celecoxib (Celebrex), researchers at the University of Pennsylvania School of Medicine found a greater risk of heart attack associated with Vioxx than Celebrex, although neither of the two drugs showed a statistically significant elevated risk of heart attack relative to people who did not use the drugs.

8 Dec 2004

Drugs News and Research

Risk of having a heart attack is elevated in the weeks after stopping use of nonsteroidal anti-inflammatory drugs

Instead of chemotherapy, drugs that influence the X protein's behavior might become an alternative cancer therapy

Link found between bisphosphonates and a serious bone disease called osteonecrosis of the jaw

Celebrex like gene suppresses the growth of colon cancer

Successful human trial of obesity drug that mimicks metabolic effects of growth hormone

Compounds in Christmas trees could help treat arthritis and pain

Wiping out a protein in skin cancer cells could significantly stall melanoma tumor development

FDA accepts Genmab's Investigational New Drug Application for active rheumatoid arthritis treatment

Findings could lead to new knowledge that could speed the development of drugs to block botulism or tetanus toxins more rapidly

Computational model of addiction which can be used to make predictions about human behavior

Newly discovered genetic defect might represent an important risk factor for major depression

Lupus drug may also be useful in treating psoriasis

Novel anti-rejection protocol should allow major improvement efficacy and quality of life after intestinal and multivisceral transplants

Importance of the phosphatidylinositol 3 kinase (PI3K) pathway to breast cancer development

Study sheds light on how bacteria persist despite antibiotics

Pharmaceutical, biotechnology and drug discovery companies are increasingly turning their attention to cell-based assays

Excellent news for the many people who suffer from high blood pressure

Wide angle X-ray scattering (WAXS) could help produce lead drugs for disease therapy

Need to correct racial disparities in health

Greater risk of heart attack associated with Vioxx than Celebrex

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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