B Cell News and Research

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MUSC researchers unravel the mystery of cancer recurrence

MUSC Hollings Cancer Center researchers have unlocked a discovery that could help to explain why cancer can recur in patients who have undergone chemotherapy or radiotherapy.

28 May 2024

Light therapy may affect healing in the brains of people who suffered traumatic brain injury

Low-level light therapy appears to affect healing in the brains of people who suffered significant brain injuries, according to a study published today in Radiology, a journal of the Radiological Society of North America.

28 May 2024

Underappreciated set of enzymes connected to the regulation of hippo pathway in cancer

Within the family of cell membrane lipids known as phosphoinositides and the kinase enzymes that regulate them, phosphoinositide 3-kinases (PI3Ks) have been cast in a starring role as scientists study their involvement in cancer, diabetes and many cellular activities.

28 May 2024

Research reveals loneliness as a complex interplay of social impairments, oxytocin, and illness

A recent review in the journal Neuroscience & Biobehavioral Reviews presents a multidimensional model of loneliness, exploring its impact on social interactions, the oxytocin system, and illness. The study emphasizes the need for multidisciplinary collaboration to understand and address loneliness effectively.

28 May 2024

New paper reveals the broad potential of TNIK as a therapeutic target for some aging-related diseases

A new paper in Trends in Pharmacological Sciences from researchers at generative artificial intelligence (AI)- and robotics-powered clinical stage drug discovery company Insilico Medicine ("Insilico") and ETH Zurich reveals the broad potential of TNIK as a therapeutic target for some of the most pervasive aging-related diseases, including fibrosis, cancer, obesity, and Alzheimer's.

28 May 2024

Understanding the link between EBV-infected B cells and multiple sclerosis

The Wistar Institute's Paul M. Lieberman, Ph.D., and lab team led by senior staff scientist and first author, Samantha Soldan, Ph.D., have demonstrated how B cells infected with the Epstein-Barr virus (EBV) can contribute to a pathogenic, inflammatory phenotype that contributes to multiple sclerosis (MS); the group has also shown how these problematic B cells can be selectively targeted in a way that reduces the damaging autoimmune response of multiple sclerosis.

28 May 2024

Study reveals pivotal role of the circadian clock in enhancing checkpoint inhibitor cancer therapy

A multidisciplinary research team at the University of California, Irvine has revealed that the circadian clock – the biological pacemaker that governs daily rhythms in physiological processes, including immune functions – can be leveraged to enhance the efficacy of checkpoint inhibitor cancer therapy.

28 May 2024

Understanding genetic mosaicism in human cells

In a study led by Jan Korbel at the European Molecular Biology Laboratory (EMBL) and Ashley Sanders at the Berlin Institute for Medical Systems Biology of the Max Delbrück Center (MDC-BIMSB), researchers have found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations – copy number variations and chromosomal rearrangements, for example – without causing any apparent disease or abnormality.

28 May 2024

New subset of T cells may enhance cancer immunotherapy

A team of cancer researchers, led by the University of Houston, has discovered a new subset of T cells that may improve the outcome for patients treated with T-cell therapies.

28 May 2024

Researchers discover how protein XPD detects and repairs DNA damage

Researchers at the University of Würzburg, led by Caroline Kisker in cooperation with Claudia Höbartner, discovered how the protein XPD detects a severe DNA damage and controls its repair.

28 May 2024

Researchers develop mathematical model to predict effective dosage range of cancer treatment

Cancer poses significant challenges due to the development of resistance and the likelihood of relapse. Resistance may arise from permanent genetic changes in cancer cells or non-genetic alterations in cancer cell behavior induced by treatment.

28 May 2024

Changing the landscape of R&D to build clinical success from the ground up

In this interview, NewsMedical talks to Amanda Jones at Revvity about the strategies and solutions available to revolutionize the landscape of R&D in clinical research.

From Revvity 28 May 2024

Heart failure triggers multimorbidity by altering stem cells, study reveals

Researchers identified that heart failure (HF) promotes multimorbidity by altering hematopoietic stem cells (HSCs) to produce pro-inflammatory macrophages, increasing vulnerability in multiple organs. The study highlights the role of suppressed TGF-β signaling in these alterations, contributing to chronic inflammation and subsequent health issues.

28 May 2024

Study reveals cancer treatment disparities at minority-serving hospitals

It’s important to ensure that care provided at US hospitals that predominantly serve Black and Hispanic populations is as high-quality as the care provided at other US hospitals.

27 May 2024

Researchers identify novel way to potentially slow down or halt Alzheimer’s progression

Researchers at the Icahn School of Medicine at Mount Sinai have made a significant breakthrough in Alzheimer's disease research by identifying a novel way to potentially slow down or even halt disease progression.

27 May 2024

Study finds rise in hospitalizations for ischemic priapism

Researchers analyzed nationwide data from Germany to evaluate trends and outcomes in hospitalized cases of high- and low-flow priapism, finding increased hospitalizations for ischemic priapism and reduced cases linked to sickle cell disease.

26 May 2024

Hybrid technique identifies anti-nephrin autoantibodies as biomarker for kidney disorders with nephrotic syndrome

A groundbreaking study, presented today at the 61st ERA Congress, has uncovered a significant breakthrough in the diagnosis and monitoring of kidney diseases associated with nephrotic syndrome.

25 May 2024

Advanced techniques reveal plectasin's velcro-like action against bacteria

A small antibiotic called plectasin uses an innovative mechanism to kill bacteria. By assembling into large structures, plectasin latches onto its target on the bacterial cell surface comparable to how both sides of Velcro form a bond.

25 May 2024

AI-based body composition analysis predicts lung cancer treatment outcomes

Tafadzwa Chaunzwa, MD, a researcher in the Artificial Intelligence in Medicine (AIM) Program at Mass General Brigham and a senior resident physician at the Harvard Radiation Oncology Program, is the lead author of a paper published in JAMA Oncology.

24 May 2024

Study sheds new light on the intricate molecular mechanisms underlying schizophrenia

Schizophrenia is a complex disease with variable presentations, and the diverse nature of this mental health disorder has made understanding the mechanisms that cause the disease, and subsequently developing effective treatments, especially challenging.

24 May 2024

B Cell News and Research

MUSC researchers unravel the mystery of cancer recurrence

Light therapy may affect healing in the brains of people who suffered traumatic brain injury

Underappreciated set of enzymes connected to the regulation of hippo pathway in cancer

Research reveals loneliness as a complex interplay of social impairments, oxytocin, and illness

New paper reveals the broad potential of TNIK as a therapeutic target for some aging-related diseases

Understanding the link between EBV-infected B cells and multiple sclerosis

Study reveals pivotal role of the circadian clock in enhancing checkpoint inhibitor cancer therapy

Understanding genetic mosaicism in human cells

New subset of T cells may enhance cancer immunotherapy

Researchers discover how protein XPD detects and repairs DNA damage

Researchers develop mathematical model to predict effective dosage range of cancer treatment

Changing the landscape of R&D to build clinical success from the ground up

Heart failure triggers multimorbidity by altering stem cells, study reveals

Study reveals cancer treatment disparities at minority-serving hospitals

Researchers identify novel way to potentially slow down or halt Alzheimer’s progression

Study finds rise in hospitalizations for ischemic priapism

Hybrid technique identifies anti-nephrin autoantibodies as biomarker for kidney disorders with nephrotic syndrome

Advanced techniques reveal plectasin's velcro-like action against bacteria

AI-based body composition analysis predicts lung cancer treatment outcomes

Study sheds new light on the intricate molecular mechanisms underlying schizophrenia

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