Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Four-gene/protein signature more accurately predicts metastatic prostate cancer

Prostate tumors that carry a "signature" of four molecular markers have the potential to become dangerously metastatic if not treated aggressively, researchers at Dana-Farber Cancer Institute report in a study published online today by the journal Nature. The discovery lays the groundwork for the first gene-based test for determining whether a man's prostate cancer is likely to remain dormant within the prostate gland, or spread lethally to other parts of the body.

3 Feb 2011

Inovio publishes scientific paper detailing SynCon DNA vaccine preclinical study for prostate cancer

Inovio Pharmaceuticals, a leader in the development of therapeutic and preventive vaccines against cancers and infectious diseases, announced today the publication of a scientific paper in the journal Human Vaccines detailing potent immune responses in a preclinical study of Inovio's SynCon DNA vaccine for prostate cancer targeting two antigens.

2 Feb 2011

EA sponsors research grant to investigate specific cancers and kinase mutations

Expression Analysis today announced a jointly sponsored research grant for up to eight American Cancer Society Grantees to investigate and draw parallels between specific cancers and recurring mutations in specific kinases, using targeted genome sequencing.

2 Feb 2011

Fluidigm launches new BioMark HD Real-time PCR System for genomic analysis

Fluidigm today introduced the new BioMark HD Real-time PCR System, the company's most advanced instrument for genomic analysis ever. The BioMark HD System is designed for researchers who require the sensitivity and throughput needed to study gene expression down to the single-cell level -- especially those who have limited amounts of sample or study rare populations of cells.

1 Feb 2011

Gut bacteria may influence mammalian brain development and adult behavior

A team of scientists from across the globe have found that gut bacteria may influence mammalian brain development and adult behavior. The study is published in the scientific journal PNAS, and is the result of an ongoing collaboration between scientists at Karolinska Institutet in Sweden and the Genome Institute of Singapore.

1 Feb 2011

Researchers discover 'common set of dysregulated miRNAs in murine lupus models'

Potentially impacting future diagnosis and treatment of lupus, an immune illness affecting more than 5 million people worldwide, researchers at the Virginia-Maryland Regional College of Veterinary Medicine at Virginia Tech have likely uncovered where the breakdown in the body's lymphocyte molecular regulatory machinery is occurring.

1 Feb 2011

VBL commences two studies to evaluate efficacy, safety of VB-111 in advanced cancers

VBL Therapeutics, a clinical-stage biotechnology company committed to the development of novel treatments for immune-inflammatory diseases and cancer, today announced the initiation of two studies to further evaluate the efficacy and safety of VB-111 in advanced cancers.

31 Jan 2011

Inovio announces regulatory approval for Phase 2 trial to treat leukemia using new vaccine delivery device

Inovio Pharmaceuticals, a leader in the development of therapeutic and preventive vaccines against cancers and infectious diseases, announced today the regulatory approval of a Phase 2 clinical trial to treat leukemia utilizing Inovio's new ELGEN 1000 automated vaccine delivery device.

31 Jan 2011

EA receives CLIA certification for clinical laboratory testing

Expression Analysis, a leading provider of genomic services for clinical trials and research, announced today it has received CLIA certification. This milestone comes as the company enters its tenth year of providing genomic expertise; something the company refers to as "Genomic Know-How.

29 Jan 2011

GE Capital provides capital to XDx to help increase commercialization of AlloMap molecular diagnostic test

GE Capital, Healthcare Financial Services announced today that it has provided, as sole lender, a $12.5 million senior secured multi-draw term loan facility to XDx, Inc. The financing provides XDx with working capital to expand the commercialization of its FDA-cleared, innovative, noninvasive AlloMap molecular diagnostic test and pursue the development of other gene expression-based tests for autoimmune diseases including lupus.

29 Jan 2011

Athersys enters definitive agreements to sell common stock, warrants

Athersys, announced today that it has entered into definitive agreements with certain investors to sell 4,366,667 shares of its common stock and warrants to purchase up to an additional 1,310,000 shares of common stock in a registered direct offering for gross proceeds of approximately $13.1 million, before deducting fees and offering expenses.

29 Jan 2011

Research provides new clues for compulsive behavior, cognitive defects linked with LND

Research from the University of California, San Diego School of Medicine provides new clues for the compulsive behavior and cognitive defects associated with a rare childhood neurological disease called Lesch-Nyhan Disease.

29 Jan 2011

XDx establishes $12.5 million multi-draw term loan facility with GE Capital

XDx, a San Francisco-based molecular diagnostics company focused on non-invasive gene expression-based tests for the monitoring of organ transplant rejection and autoimmune diseases, announced today that it has established a $12.5 million senior secured multi-draw term loan facility with GE Capital, Healthcare Financial Services.

28 Jan 2011

Preclinical data on Inovio’s intradermal electroporation delivery devices presented at Phacilitate Vaccine Forum

Inovio Pharmaceuticals, Inc., a leader in the development of novel therapeutic and preventive vaccines against cancers and infectious diseases, announced today the presentation of recent preclinical data using its next generation of minimally invasive intradermal (skin) electroporation delivery devices at the Phacilitate Vaccine Forum 2011 in Washington, DC.

28 Jan 2011

New molecular player responsible for regulation of appetite and metabolism

A study by researchers at Mayo Clinic's campus in Florida and Washington University School of Medicine adds a new twist to the body of evidence suggesting human obesity is due in part to genetic factors. While studying hormone receptors in laboratory mice, neuroscientists identified a new molecular player responsible for the regulation of appetite and metabolism.

28 Jan 2011

Scientists discover new mechanism neurons use to fine-tune electrical output

Scientists in the Hotchkiss Brain Institute at the Faculty of Medicine, University of Calgary, have discovered a new mechanism that nerve cells (neurons) use to fine-tune their electrical output. The exciting discovery, published this week in the prestigious journal Nature Neuroscience, provides new insights about how the activity of the nervous system is regulated at the cellular level.

27 Jan 2011

NuGEN, Caliper enter co-marketing agreement in next generation sequencing sample preparation methods

NuGEN Technologies, Inc. and Caliper Life Sciences, Inc. today announced a co-marketing agreement for the development of automated methods for next generation sequencing sample preparation on Caliper's Sciclone® NGS Workstation.

27 Jan 2011

NuGEN expands NGS utility for microbial transcriptome analysis with Ovation Prokaryotic RNA-Seq System

NuGEN Technologies, a leader in genomics sample preparation, expands the utility of next-generation sequencing for the analysis of microbial species and microbiome samples with its Ovation Prokaryotic RNA-Seq System.

27 Jan 2011

NanoString Technologies launches nCounter Mouse miRNA Expression Assay Kit

NanoString Technologies, Inc., a privately held life sciences company marketing a complete solution for detecting and counting large sets of target molecules in biological samples, today announced the expansion of its microRNA (miRNA) product line with a multiplexed assay for profiling the mouse miRNA transcriptome.

From NanoString Technologies 25 Jan 2011

Study results of Pathwork Diagnostics's Tissue of Origin Test presented at ASCO 2011

Pathwork Diagnostics, Inc., a privately held molecular diagnostics company focused on oncology, announced today that results from a decision impact study of its Tissue of Origin Test were presented this weekend at the ASCO 2011 Gastrointestinal Cancers Symposium in San Francisco.

25 Jan 2011

Gene Expression News and Research

Further Reading

Four-gene/protein signature more accurately predicts metastatic prostate cancer

Inovio publishes scientific paper detailing SynCon DNA vaccine preclinical study for prostate cancer

EA sponsors research grant to investigate specific cancers and kinase mutations

Fluidigm launches new BioMark HD Real-time PCR System for genomic analysis

Gut bacteria may influence mammalian brain development and adult behavior

Researchers discover 'common set of dysregulated miRNAs in murine lupus models'

VBL commences two studies to evaluate efficacy, safety of VB-111 in advanced cancers

Inovio announces regulatory approval for Phase 2 trial to treat leukemia using new vaccine delivery device

EA receives CLIA certification for clinical laboratory testing

GE Capital provides capital to XDx to help increase commercialization of AlloMap molecular diagnostic test

Athersys enters definitive agreements to sell common stock, warrants

Research provides new clues for compulsive behavior, cognitive defects linked with LND

XDx establishes $12.5 million multi-draw term loan facility with GE Capital

Preclinical data on Inovio’s intradermal electroporation delivery devices presented at Phacilitate Vaccine Forum

New molecular player responsible for regulation of appetite and metabolism

Scientists discover new mechanism neurons use to fine-tune electrical output

NuGEN, Caliper enter co-marketing agreement in next generation sequencing sample preparation methods

NuGEN expands NGS utility for microbial transcriptome analysis with Ovation Prokaryotic RNA-Seq System

NanoString Technologies launches nCounter Mouse miRNA Expression Assay Kit

Study results of Pathwork Diagnostics's Tissue of Origin Test presented at ASCO 2011

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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