Nephrology News and Research

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Nephrology is a branch of internal medicine and pediatrics dealing with the study of the function and diseases of the kidney.

Warning against colloids in fluid resuscitation

Hydroxyethyl starch offers no benefits over saline for fluid resuscitation in critically ill patients and may have renal consequences, shows a randomized trial.

23 Oct 2012

Donor gene clue to kidney transplant rejection

Genetic study results show that long-term kidney transplant rejection risk may be increased if the organ donor has a variant form of the multidrug resistance 1 gene.

23 Oct 2012

Methylation provides clues to gastric cancer subtypes

Research published in Science Translational Medicine shows that many gastric cancers are associated with significant epigenetic alterations along the DNA triggered by methylation.

22 Oct 2012

Primary care physicians miss hepatitis vaccine targets

Primary care physicians are failing to meet guidelines for hepatitis A virus and hepatitis B virus vaccination in patients with chronic hepatitis C infection, according to US research.

22 Oct 2012

$Ustekinumab success in refractory Crohn’s disease$

Ustekinumab success in refractory Crohn’s disease

Patients with Crohn’s disease who have failed to respond adequately to anti–tumor necrosis factor treatment may benefit from the monoclonal antibody ustekinumab, results of a double-blind, placebo-controlled trial suggest.

22 Oct 2012

Closer to engineering new kidney tissue

With a worldwide shortage of kidneys for patients who need kidney transplants, researchers are diligently working to find ways to engineer new kidney tissue from a patient's own cells or another source. They've come a step closer to realizing that goal with a breakthrough described in an upcoming Journal of the American Society of Nephrology (JASN) study.

20 Oct 2012

Clinical trial to study immunosuppressant tacrolimus against generics

A new study at the University of Cincinnati seeks to end the questions over generic-vs.-brand for a common immunosuppressive drug for transplant patients, tacrolimus.

20 Oct 2012

Kaiser Permanente Research Affiliates receives prestigious designation from AHRQ

A new research collaboration led by Kaiser Permanente has received a prestigious designation from the federal Agency for Healthcare Research and Quality to serve of as one of the nation's 11 Evidence-based Practice Centers.

20 Oct 2012

NIH-funded study of weight loss in adults with type 2 diabetes finds no cardiovascular benefits

An intensive diet and exercise program resulting in weight loss does not reduce cardiovascular events such as heart attack and stroke in people with longstanding type 2 diabetes, according to a study supported by the National Institutes of Health.

20 Oct 2012

Damage of endothelial glycocalyx may lead to heart troubles in kidney failure patients

Individuals with kidney failure often develop heart problems, but it's not clear why. A study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN) provides evidence that their kidneys' inability to excrete waste products in the urine, which leads to build-up of these products in the blood, may damage the sugary lining of blood vessels and lead to heart troubles.

20 Oct 2012

Daily whole body vibration may combat prediabetes in adolescents

Daily sessions of whole-body vibration may combat prediabetes in adolescents, dramatically reducing inflammation, average blood glucose levels and symptoms such as frequent urination, researchers report.

20 Oct 2012

Liver x receptor plays an important role in diabetic nephropathy

Researchers have discovered a new therapeutic target for diabetic nephropathy, the leading cause of kidney failure.

19 Oct 2012

Study hopes to improve the outlook for native Americans with kidney disease

Americans have a 1 in 10 chance of suffering from kidney disease, according to statistics from the Centers for Disease Control and Prevention. For Native Americans, the risk doubles.

19 Oct 2012

Longer looks: A Nobel for the economist behind the National Resident Matching Program; Helping Charlie end his life

A noted economist at Harvard, (Al) Roth was responsible for algorithms that matched medical students with their residency programs, children with their schools in Boston, and more recently, compatible kidney donors and transplant patients in paired donations.

19 Oct 2012

Active surveillance of small kidney masses offers similar cancer outcomes to radical or partial surgery

Active surveillance of small kidney masses is a safe and effective alternative to immediate surgery, with similar overall and cancer specific survival rates, according to a study published in the November issue of the urology journal BJUI.

19 Oct 2012

Phase 3 study of INLYTA fails to meet primary endpoint in treatment-naïve patients with RCC

Pfizer Inc. announced today that a Phase 3 study of INLYTA (axitinib) did not meet its primary endpoint of demonstrating statistically significantly longer progression-free survival, versus sorafenib, in treatment-naïve patients with advanced renal cell carcinoma.

18 Oct 2012