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Moderna booster vaccination overcomes SARS-CoV-2 Omicron variant antibody escape

A new study reports the results of a study focused on immune evasion characteristics, specifically the ability to escape neutralization by antibodies to the earlier SARS-CoV-2 variants or to the spike antigen used in COVID-19 vaccines.

16 Dec 2021

Therapeutic antibodies deemed ineffective against Omicron variant of SARS-CoV-2

A new study found that the Omicron S protein evades antibodies with a 44-fold higher efficiency than the Delta variant's spike, rendering therapeutic antibodies ineffective and likely negatively impacting antibody protection induced by infection or double vaccination.

16 Dec 2021

Experimental and computational synergy considered a promising approach in COVID-19 patients

Thanks to the large amount of -omics data becoming increasingly available, sophisticated computational models are developed for new fields such as immunology and the predictions they generate will help identify key molecules in inflammatory processes.

16 Dec 2021

Neutralization potency of COVID-19 vaccine boosters against SARS-CoV-2 variant pseudoviruses

A new study has used this assay to evaluate sera, obtained from 239 individuals vaccinated via any of the above-stated vaccines against SARS-CoV-2’s original strain, the Delta, and Omicron SARS-CoV-2 pseudoviruses.

16 Dec 2021

Human monoclonal antibody protects against SARS-CoV-2 and SARS-CoV in vivo

Scientists identified a human monoclonal antibody (mAb), which successfully neutralized or bound all sarbecoviruses tested in vitro.

16 Dec 2021

Exploring the plasma neutralization properties of the Omicron variant of SARS-CoV-2

A new study determines the ability of individuals with varying exposure to SARS-CoV-2 infection and vaccination, to neutralize SARS- CoV-2 pseudotypes.

16 Dec 2021

Evaluation of SARS-CoV-2 neutralizing antibodies in mothers and infants

A new study assessed nAb activities against five strains of SARS-CoV-2 in paired maternal and infant cord blood samples.

15 Dec 2021

How SARS-CoV-2 affects the male reproductive system

Researchers review the potentially harmful consequences on the male reproductive system in COVID-19 patients.

15 Dec 2021

Evaluation of SARS-CoV-2 Omicron's immune evasion potential

Researchers use VSV vector and Omicron spike protein containing all 32 mutations to create the pseudotyped SARS-CoV-2 Omicron variant (PV-Omicron).

15 Dec 2021

Weak T-cell clonal response to SARS-CoV-2 vaccination in IBD patients deficient in antibody-responders

Researchers investigate the post-vaccination clonal T-cell response and its relationship to antibody responses in IBD patients.

15 Dec 2021

Discovery can pave the way for new strategies to reduce atherosclerosis using omega-3 fatty acids

A receptor activated by substances formed from omega-3 fatty acids plays a vital role in preventing inflammation in blood vessels and reducing atherosclerosis, a new study from Karolinska Institutet in Sweden published in The Journal of Clinical Investigation reports.

15 Dec 2021

Combination treatment can effectively inhibit tumor growth

Researchers at the Paul Scherrer Institute PSI have tested various methods to check how effective they are in combatting certain types of cancer.

15 Dec 2021

Novel bioinformatics pipeline for fast and scalable analysis of large viral phylogenies

A team of researchers recently developed a bioinformatics approach to analyze viral phylogenetic clusters.

15 Dec 2021

Exploring the possibility of developing a plant-based oral vaccine against COVID-19

New research optimizes methods for the in-planta expression of the recombinant protein corresponding to the Receptor Binding Domain (RBD) subunit of the surface-exposed Spike glycoprotein of SARS-CoV-2.

15 Dec 2021

Receptor binding of SARS-CoV-2 Omicron variant compared to other variants

Researchers compared the binding of the new SARS-CoV-2 VOC Omicron’s RBD and ACE2 receptor with the original Wuhan SARS-CoV-2 strain and other VOCs such as Beta and Delta.

15 Dec 2021

SARS-CoV-2 Omicron variant binding to its receptor and therapeutic entities

Researchers generated a set of computed structural models of the Omicron receptor-binding domain attached to its receptor angiotensin-converting enzyme.

15 Dec 2021

Monoclonal antibody activity against SARS-CoV-2 Omicron variant

Scientists from Germany have recently pointed out that the third booster dose of mRNA-based COVID-19 vaccine is highly effective in neutralizing the omicron variant of SARS-CoV-2.

15 Dec 2021

Structure of human receptor and Omicron variant

Researchers studied the complex structure of the receptor-binding domain of the omicron variant with the human host receptor angiotensin-converting enzyme 2.

15 Dec 2021

Study provides new insights into molecular drivers of treatment resistance in prostate cancer

An international research team co-led by scientists at Roswell Park Comprehensive Cancer Center and The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute has identified an important accelerator of treatment-resistant prostate cancer.

14 Dec 2021

Omicron evades immunity more than other SARS-CoV-2 variants

Researchers find that the SARS-CoV-2 Omicron variant shows a much more extensive escape from vaccine-elicited immunity.

14 Dec 2021

Receptor News and Research

Moderna booster vaccination overcomes SARS-CoV-2 Omicron variant antibody escape

Therapeutic antibodies deemed ineffective against Omicron variant of SARS-CoV-2

Experimental and computational synergy considered a promising approach in COVID-19 patients

Neutralization potency of COVID-19 vaccine boosters against SARS-CoV-2 variant pseudoviruses

Human monoclonal antibody protects against SARS-CoV-2 and SARS-CoV in vivo

Exploring the plasma neutralization properties of the Omicron variant of SARS-CoV-2

Evaluation of SARS-CoV-2 neutralizing antibodies in mothers and infants

How SARS-CoV-2 affects the male reproductive system

Evaluation of SARS-CoV-2 Omicron's immune evasion potential

Weak T-cell clonal response to SARS-CoV-2 vaccination in IBD patients deficient in antibody-responders

Discovery can pave the way for new strategies to reduce atherosclerosis using omega-3 fatty acids

Combination treatment can effectively inhibit tumor growth

Novel bioinformatics pipeline for fast and scalable analysis of large viral phylogenies

Exploring the possibility of developing a plant-based oral vaccine against COVID-19

Receptor binding of SARS-CoV-2 Omicron variant compared to other variants

SARS-CoV-2 Omicron variant binding to its receptor and therapeutic entities

Monoclonal antibody activity against SARS-CoV-2 Omicron variant

Structure of human receptor and Omicron variant

Study provides new insights into molecular drivers of treatment resistance in prostate cancer

Omicron evades immunity more than other SARS-CoV-2 variants

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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