Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Exiqon launches 2nd generation of miRCURY LNA microRNA Inhibitor libraries for genome-wide screening

Exiqon A/S, a leading supplier of high-value gene expression analysis products, today announced the launch of the 2nd generation of miRCURY LNA microRNA Inhibitor libraries for genome-wide screening of microRNA function in human and mouse. Several libraries have already been shipped to the first customers.

12 Jan 2011

Affymetrix enters distribution agreement with Fisher Scientific for GeneAtlas System

Affymetrix, Inc. today announced that it has signed a distribution agreement with Fisher Scientific, Inc., part of Thermo Fisher Scientific, to distribute the GeneAtlas™ System and its related consumables through the Fisher Scientific channel throughout the United States and Canada.

From Thermo Fisher Scientific Inc. 12 Jan 2011

Lipoprotein receptor LRP1 also regulates food intake and energy balance in central nervous system: Study

A study by researchers at Mayo Clinic's campus in Florida and Washington University School of Medicine adds a new twist to the body of evidence suggesting human obesity is due in part to genetic factors. While studying hormone receptors in laboratory mice, neuroscientists identified a new molecular player responsible for the regulation of appetite and metabolism.

12 Jan 2011

Analysis of medical database reveals new diagnostic markers for allergic disorders

Researchers at the University of Gothenburg, Sweden, have developed new methods for analysing medical databases that can be used to identify diagnostic markers more quickly and to personalise medication for allergic disorders. They could also reduce the need for animal trials in clinical studies.

12 Jan 2011

Study identifies over 30 breast cancer gene targets involved in drug resistance to chemotherapy

A new study conducted by Josh LaBaer's research team in the Biodesign Institute at Arizona State University has pinpointed more than 30 breast cancer gene targets ---including several novel genes---that are involved in drug resistance to a leading chemotherapy treatment.

11 Jan 2011

GSK, Epizyme enter partnership to discover, develop, and market epigenetic therapeutics

Epizyme today announced a worldwide strategic alliance with GlaxoSmithKline to discover, develop, and market novel small molecule therapeutics targeting histone methyltransferases, an important class of epigenetic enzymes, for the treatment of cancer and other diseases.

11 Jan 2011

Study: Protein that plays a key role in some antioxidant therapies can promote atherosclerosis

UCLA researchers have found that a protein that plays an important role in some antioxidant therapies may not be as effective due to additional mechanisms that cause it to promote atherosclerosis, or clogging of the arteries.

11 Jan 2011

All fat cells not the same

All fat cells are not the same - a fact that has implications in the understanding and treatment of type 2 diabetes and obesity, said researchers from Baylor College of Medicine (www.bcm.edu) in a report that appears in the current issue of the Journal of Cell Biology (http://www.jcb.rupress.org/).

10 Jan 2011

Sangamo completes enrollment in SB-509-901 Phase 2b clinical trial in diabetic neuropathy

Sangamo BioSciences, Inc. announced today that the company completed enrollment of its Phase 2b double-blind, placebo-controlled clinical trial (SB-509-901) in subjects with diabetic neuropathy (DN). The company expects to have efficacy data from this study in the second half of 2011. The company also plans to present the first human clinical data from its Phase 1 trials of SB-728-T in HIV/AIDS in the first quarter of 2011.

10 Jan 2011

MMRF awards $3 million under 2010 Biotech Investment Awards program

The Multiple Myeloma Research Foundation (MMRF) today announced that it has awarded $1 million to each of three Boston-area biotech companies through its 2010 Biotech Investment Awards program: Constellation Pharmaceuticals, Inc., Epizyme, Inc. and Karyopharm Therapeutics, Inc. Since the inception of this MMRF program in 2006, $11 million has been committed to 11 biotech companies in multi-year, results-driven funding for the development of innovative treatments for patients with multiple myeloma.

7 Jan 2011

Athersys completes patient enrollment in MultiStem Phase I study for leukemia

Athersys, Inc. today announced that it has completed patient enrollment of the single dose arm of a clinical study involving administration of MultiStem to patients being treated for leukemia or other blood born cancers.

7 Jan 2011

JMD publishes results of Tissue of Origin Test validation, reproducibility study

Pathwork Diagnostics, Inc., a privately held molecular diagnostics company focused on oncology, announced today that The Journal of Molecular Diagnostics has published the results of a significant Tissue of Origin Test validation and reproducibility study.

6 Jan 2011

Signal Genetics, Caris Life Sciences announce new agreement to commercialize MyPRS tool

Signal Genetics, the parent company of Myeloma Health LLC, a privately held predictive genetic testing company focused on oncology, and Caris Life Sciences, Inc., a leading biosciences company focused on enabling precise and personalized healthcare through the highest quality anatomic pathology, molecular profiling and blood-based diagnostic services, today announced a new agreement under which Caris Life Sciences will offer Signal Genetics' new gene expression profile test for Multiple Myeloma to community-based hematologists/medical oncologists nationwide.

6 Jan 2011

Mutated TDP-43 can cause neurons to die: Study

Lou Gehrig's disease, or amyotrophic lateral sclerosis, and frontotemporal lobar degeneration are characterized by protein clumps in brain and spinal-cord cells that include an RNA-binding protein called TDP-43. This protein is the major building block of the lesions formed by these clumps.

6 Jan 2011

Odyssey Thera granted U.S. Patent for high-throughput screening of proteins

Odyssey Thera, Inc. announced today that the United States Patent and Trademark Office granted U.S. Patent No. 7,855,167. The invention describes technologies and high-throughput methods for identifying bimolecular interactions in vivo based on protein-fragment complementation assays.

6 Jan 2011

Celgene announces regulatory submissions for blood cancer therapies REVLIMID and ISTODAX

Celgene International Sàrl announced regulatory submissions for its blood cancer therapies REVLIMID (lenalidomide) and ISTODAX (romidepsin).

5 Jan 2011

New mouse model with deficiency of lipoprotein lipase in neurons

Researchers at the University of Colorado School of Medicine have created a new and exciting mouse model to study how lipid sensing and metabolism in the brain relate to the regulation of energy balance and body weight. The research team, led by Hong Wang, PhD, created mice with a deficiency of lipoprotein lipase (LPL) in neurons, and observed two important reactions.

5 Jan 2011

Cold Spring Harbor Protocols features organ culture methods and transcriptome analysis

New technologies and methods are spurring a renaissance in the study of organogenesis. Organogenesis, essentially the process through which a group of cells becomes a functioning organ, has important connections to biological processes at the cellular and developmental levels, and its study offers great potential for medical treatments through tissue engineering approaches.

4 Jan 2011

CDK1 protein deactivates EZH2 enzyme that causes cancer spread

By sticking a chemical group to it at a specific site, a protein arrests an enzyme that may worsen and spread cancer, an international research team led by scientists at The University of Texas MD Anderson Cancer Center reports in the January issue of Nature Cell Biology.

4 Jan 2011

Met-FISC complex formation critical step in juvenile hormone signaling pathway

Just as raging hormones are part of the process of a child's maturation through the teen years to adulthood, juvenile hormones, a group of insect isoprenoids, play an important role as butterflies, fruit flies and mosquitoes transform their body structures as they molt from larva to pupa and then adults.

28 Dec 2010

Gene Expression News and Research

Further Reading

Exiqon launches 2nd generation of miRCURY LNA microRNA Inhibitor libraries for genome-wide screening

Affymetrix enters distribution agreement with Fisher Scientific for GeneAtlas System

Lipoprotein receptor LRP1 also regulates food intake and energy balance in central nervous system: Study

Analysis of medical database reveals new diagnostic markers for allergic disorders

Study identifies over 30 breast cancer gene targets involved in drug resistance to chemotherapy

GSK, Epizyme enter partnership to discover, develop, and market epigenetic therapeutics

Study: Protein that plays a key role in some antioxidant therapies can promote atherosclerosis

All fat cells not the same

Sangamo completes enrollment in SB-509-901 Phase 2b clinical trial in diabetic neuropathy

MMRF awards $3 million under 2010 Biotech Investment Awards program

Athersys completes patient enrollment in MultiStem Phase I study for leukemia

JMD publishes results of Tissue of Origin Test validation, reproducibility study

Signal Genetics, Caris Life Sciences announce new agreement to commercialize MyPRS tool

Mutated TDP-43 can cause neurons to die: Study

Odyssey Thera granted U.S. Patent for high-throughput screening of proteins

Celgene announces regulatory submissions for blood cancer therapies REVLIMID and ISTODAX

New mouse model with deficiency of lipoprotein lipase in neurons

Cold Spring Harbor Protocols features organ culture methods and transcriptome analysis

CDK1 protein deactivates EZH2 enzyme that causes cancer spread

Met-FISC complex formation critical step in juvenile hormone signaling pathway

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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