immunity News and Research

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New compound can reduce overactivation without impairing the body's immunity response

When the body detects a pathogen, such as bacteria or viruses, it mounts an immune system response to fight this invader. In some people, the immune system overreacts, resulting in an overactive immune response that causes the body to injure itself, which may prove fatal in some cases.

10 Mar 2021

New SARS-CoV-2 vaccine candidate produces strong immune response, prevents SARS-CoV-2 infection

A new SARS-CoV-2 vaccine candidate, developed by giving a key protein's gene a ride into the body while encased in a measles vaccine, has been shown to produce a strong immune response and prevent SARS-CoV-2 infection and lung disease in multiple animal studies.

10 Mar 2021

Delaying second doses of COVID-19 vaccines has benefits, but longer-term results rely on robust immunity

Delaying second doses of COVID-19 vaccines should reduce case numbers in the near term.

10 Mar 2021

Analysis shows moderate evidence for SARS-CoV-2 recombination

Recently, a team of researchers from the US performed a comprehensive recombination analysis across all medically relevant human coronaviruses, including 158,118 public seasonal hCoV, SARS-CoV-1, SARS-CoV-2, and MERS-CoV genome sequences with the help of the RDP4 software. They aimed at identifying the current and future risks of the emergence of recombinants of SARS-CoV-2

10 Mar 2021

New study assesses the effects of one versus two doses of COVID-19 vaccine

While receiving just one dose of a two-dose SARS-CoV-2 vaccine tends to decrease infections in the short-term if it produces a strong immune response, it may increase the potential for the virus to "escape" therapies in the longer-term if one-dose vaccinal immunity is weak.

9 Mar 2021

Translational research results in promising combination therapeutic candidate for type 1 diabetes

Translational research led by scientists at La Jolla Institute for Immunology (LJI) has resulted in a promising combination therapeutic candidate for adults with recent-onset type 1 diabetes.

9 Mar 2021

A genetic variant of TMPRSS2 may confer protection against severe COVID-19

Among a large sample of COVID-19 patients, researchers found that a genetic variant – caused by an amino acid substitution from valine to methionine – is associated with a reduced chance of severe disease.

9 Mar 2021

Researchers report zoonotic spillover of adapted SARS-CoV-2 from minks to humans

In a recent report made available on bioRxiv* preprint server, researchers from Poland and Finland reveal a spillover event of mink-adapted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from farmed mink to humans after an extensive adaptation process.

9 Mar 2021

Greater cross-neutralization against UK SARS-CoV-2 variant in vaccinated individuals with prior infection

A team of researchers in Spain has observed that, of those who have been vaccinated against SARS-CoV-2, higher titers of neutralizing antibodies for the B.1.1.7 variant (originating in the UK) were present in those who had previously been infected with the virus.

9 Mar 2021

Optimized SARS-CoV-2 vaccine candidate could be less reactogenic, say researchers

A new study, released as a preprint on the bioRxiv* server, reports an optimized coronavirus disease 2019 (COVID-19) vaccine candidate, which, claim the researchers, may be less likely to produce reactions like fevers. It may also have increased protective potential against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen that causes COVID-19.

9 Mar 2021

Worse problems with SARS-CoV-2 variants may be on the way

Researchers at the Department of Integrative Biomedical Sciences, University of Cape Town, South Africa, found evidence of a significant change in the selective forces acting on immunologically important SARS-CoV-2 genes, such as N and S. These likely coincided with the emergence of the 501Y lineages.

8 Mar 2021

How do viruses evolve in bats?

Bats have played a crucial epidemiological role in the evolution of many viruses and house many coronaviruses. Until 2002, coronaviruses had been known to cause mild respiratory ailments in human beings. However, this notion changed in the same year when a bat-borne virus caused the severe acute respiratory syndrome (SARS) pandemic.

8 Mar 2021

Self-assembling nanoparticles an effective vaccine candidate for SARS-CoV-2

The currently developed vaccines against SARS-CoV-2 include the RBD in their immunogen. With a similar objective, a new study developed an RBD protein-based vaccine candidate against the SARS-CoV-2, using self-assembling Helicobacter pylori-bullfrog ferritin nanoparticles as an antigen delivery system. The study is published recently in the journal mBio (by the American Society of Microbiology).

8 Mar 2021

Researchers present fragment-based computational design of antibodies that target structured epitopes

A new study describes a novel fragment-based method to design antibody complementarity determining region (CDR) loops.

8 Mar 2021

Apoptosis is an important mediator of pathogenesis in animal coronavirus infection

A new paper in the journal Life presents an early review of the viral factors involved in initiating and effecting apoptosis within infected cells.

8 Mar 2021

Novel bioinformatics tool could help improve COVID-19 diagnosis

An interesting new study by researchers at the University of Liverpool, University of Bristol and Public Health England in the UK describes a novel bioinformatics tool used to detect subgenomic messenger ribonucleic acid (mRNA) sequences from the virus. This may help develop new diagnostic tools and model the transmission of the virus.

8 Mar 2021

How can physicians distinguish between COVID-19 persistence and SARS-CoV-2 reinfection?

One of the most challenging tasks of physicians has been differentiating between persistent COVID-19 and SARS-CoV-2 reinfection. Recently, a team of researchers analyzed SARS-CoV-2 sequences from the publicly available reports on reinfection and persistence. They further characterized the markers of reinfecting sequences and studied the mutation rate in newly evolved persistent variants.

8 Mar 2021

One dose of SARS-CoV-2 vaccine candidate boosts neutralizing antibody response in COVID-19 convalescents

A new study details the results from a single dose of the FINLAY FR 1A recombinant dimeric receptor-binding domain (RBD) base vaccine during a phase I clinical trial with 30 COVID-19 convalescents to test its capacity for boosting natural immunity.

5 Mar 2021

SARS-CoV-2 proteins are potent suppressors of innate immunity

A new study describes the strong immune-suppressing activity of SARS-CoV-2 genes, among other coronavirus genes.

5 Mar 2021

Identification of neutralizing IFNL3 autoantibodies in severe COVID-19 cases

Scientists have recently developed a novel alternative molecular display technology called Molecular Indexing of Proteins by Self Assembly (MIPSA). Their research explains how this technology overcomes the critical disadvantages of PLATO and other full-length protein array technologies.

5 Mar 2021

immunity News and Research

New compound can reduce overactivation without impairing the body's immunity response

New SARS-CoV-2 vaccine candidate produces strong immune response, prevents SARS-CoV-2 infection

Delaying second doses of COVID-19 vaccines has benefits, but longer-term results rely on robust immunity

Analysis shows moderate evidence for SARS-CoV-2 recombination

New study assesses the effects of one versus two doses of COVID-19 vaccine

Translational research results in promising combination therapeutic candidate for type 1 diabetes

A genetic variant of TMPRSS2 may confer protection against severe COVID-19

Researchers report zoonotic spillover of adapted SARS-CoV-2 from minks to humans

Greater cross-neutralization against UK SARS-CoV-2 variant in vaccinated individuals with prior infection

Optimized SARS-CoV-2 vaccine candidate could be less reactogenic, say researchers

Worse problems with SARS-CoV-2 variants may be on the way

How do viruses evolve in bats?

Self-assembling nanoparticles an effective vaccine candidate for SARS-CoV-2

Researchers present fragment-based computational design of antibodies that target structured epitopes

Apoptosis is an important mediator of pathogenesis in animal coronavirus infection

Novel bioinformatics tool could help improve COVID-19 diagnosis

How can physicians distinguish between COVID-19 persistence and SARS-CoV-2 reinfection?

One dose of SARS-CoV-2 vaccine candidate boosts neutralizing antibody response in COVID-19 convalescents

SARS-CoV-2 proteins are potent suppressors of innate immunity

Identification of neutralizing IFNL3 autoantibodies in severe COVID-19 cases

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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