Antipsychotic News and Research

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Antipsychotics are medicines used to treat the symptoms of mental disorders such as schizophrenia, depression, bipolar disorder (sometimes called manic-depressive illness), anxiety disorders, and attention deficit-hyperactivity disorder (ADHD). Sometimes medications are used with other treatments such as psychotherapy.

What is the impact of cholesterol on SARS-CoV-2 Spike protein-mediated membrane fusion?

Researchers assessed the impact of ceramide (CER) and cholesterol (CHOL) on membrane fusion mediated by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein.

20 Dec 2022

'One size fits all' approach may not help address the needs of all young people with psychosis

Gold standard treatment plans for people with early psychosis have a patchy success rate, suggesting the need to develop more tailored approaches.

2 Dec 2022

Do SSRIs lower the risk of long COVID?

Researchers conducted a retrospective study to determine whether SSRIs with immunomodulatory and antiplatelet properties can decrease the risk of post-acute sequelae of COVID-19 (PASC).

15 Nov 2022

Researchers unravel how the brain chemical dopamine relates to schizophrenia

Researchers at the Lieber Institute for Brain Development (LIBD) believe they have solved a riddle that has challenged scientists for more than 70 years: how the brain chemical dopamine relates to schizophrenia, the often-devastating brain disorder characterized by delusional thinking, hallucinations and other forms of psychosis.

1 Nov 2022

People with schizophrenia are 2.5 times more likely to develop dementia

People with psychotic disorders such as schizophrenia are 2.5 times more likely than those without a psychotic disorder to eventually develop dementia, according to a review of evidence led by UCL researchers.

6 Oct 2022

Study shortlists potential drug repurposing candidates to treat symptoms in ASD

Can you teach an old drug new tricks? Although drug treatments for the core symptoms of autism spectrum disorder (ASD) are not currently available, could an existing drug provide a new treatment, even if it previously had no association with ASD? This was the question asked by a new study in the journal Frontiers in Pharmacology. The researchers used a computer model that encompasses proteins involved in ASD and the way they interact.

12 Sep 2022

HKUMed team estimates a moderate link between antipsychotic use and breast cancer by over 30%

A research team from the Centre for Safe Medication Practice and Research (CSMPR), Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong (HKUMed) conducted the world's first systematic review and meta-analysis of observational studies with over two million individuals and estimated a moderate association between antipsychotic use and breast cancer by over 30%.

9 Sep 2022

Temporo-spatial pharmacometabolomics method to evaluate microregional effect of OLZ on brain tissue

Announcing a new article publication from Acta Pharmaceutica Sinica B. The brain is the most advanced organ with various complex structural and functional microregions.

5 Sep 2022

New report provides a detailed picture of people with younger onset dementia

Younger onset dementia has a devastating impact on the lives of people diagnosed and their families, with many developing complex care needs as their illness progresses. In a new study of 5,400 people with younger onset dementia by the Australian Institute of Health and Welfare (AIHW), over half (58%) required permanent residential aged care, with 25% of these people aged under 65 at the time of entry to care.

29 Jul 2022

Repurposing an antipsychotic drug to treat various types of cancer

To treat some of the psychosis issues associated with Parkinson's disease, physicians often prescribe pimavanserin, an antipsychotic drug that acts within the brain to prevent hallucinations and delusions.

28 Jul 2022

$50 million PCORI funding approved for studies focused on treating suicidal depression and bipolar depression

Research teams at Mass General Brigham's founding members, Brigham and Women's Hospital and Massachusetts General Hospital, have been approved for more than $50 million in funding awards by the Patient-Centered Outcomes Research Institute for studies focused on treating two important mental health conditions.

26 Jul 2022

Scientists identify papain-like protease inhibitor against COVID-19

In a new study, researchers identified a papain-like protease inhibitor for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

25 Jul 2022

How common is pediatric cannabis use and what are the risks?

New research evaluated the recent usage of marijuana and its derivative products, their effects and clinical manifestations, perceptions, pharmaceutics, epidemiological studies, and the long-term ramifications in pediatric populations.

12 Jul 2022

LUCID: music, medicine, and machine learning

In this interview, News-Medical speaks to Zoë Thomson, Co-founder and Chief Innovation Officer of LUCID, about how music and machine learning are changing how we approach mental and neuropsychiatric health.

27 Jun 2022

Researchers call for nursing homes to shift to non-medication-based methods to help dementia patients

A decade-long effort to reduce medication risks for nursing home residents with dementia has paid off in some ways – but produced unintended consequences that now need addressing, new research shows.

31 May 2022

Betting on ‘golden age’ of colonoscopies, private equity invests in gastro docs

Mariel needed a new gastroenterologist. Having just moved back to San Antonio, the 30-something searched for a doctor to manage her Crohn's disease, an inflammatory bowel condition that is successfully managed with medications and lifelong monitoring — including regular colonoscopies.

27 May 2022

Cannabidiol for Parkinson's disease symptom management

Scientists have published a review study in the Journal for Nurse Practitioners that has focussed on various aspects of the use of cannabidiol in Parkinson's.

17 May 2022

Dosing recommendations should always be respected while taking herbal supplements

Herbal supplements may be natural, but that does not mean they are always safe. A new case report appearing in Heart Rhythm Case Reports, an official journal of the Heart Rhythm Society, published by Elsevier, is a case in point.

16 May 2022

Neuroimaging advances show promise in helping transcranial electrical stimulation to effectively treat visual hallucinations

A literature review in Harvard Review of Psychiatry indicates that, while transcranial electrical stimulation (tES) has rarely been used in treating visual hallucinations (VH) among patients with psychiatric disorders, recent advances in neuroimaging technology show promise in helping tES to more effectively treat VH in psychiatric disorders where VH are a core symptom.

13 May 2022

Study shows massive variations in prescribing of “comfort kit” medications by hospice agencies

When a person nearing the end of their life enters hospice care, their hospice agency's doctors may prescribe a "comfort kit" of small amounts of medications that their caregivers can give them in case of urgent, distressing symptoms such as severe anxiety, agitation, delirium, nausea and more.