Cell Metabolism News and Research

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Ketone body can strengthen the fitness and antitumor activity of CAR T cells

A naturally occurring byproduct of liver metabolism–the ketone body, β-hydroxybutyrate (BHB)–can strengthen the fitness and antitumor activity of CAR T cells.

6 Mar 2026

Researchers show red blood cells drive better glucose tolerance at high altitude

Chronic hypoxia improves glucose tolerance in mice through insulin-independent mechanisms, with red blood cells acting as a major systemic glucose sink. Increased erythrocyte production and altered glycolytic flux help reduce circulating glucose while supporting oxygen delivery to tissues.

22 Feb 2026

Low oxygen turns red blood cells into powerful glucose sinks

Scientists have long known that people living at high altitudes, where oxygen levels are low, have lower rates of diabetes than people living closer to sea level.

19 Feb 2026

Hypoxia rewires red blood cells to clear excess glucose

In a 2023 paper on hypoxia and glucose metabolism, our lab showed how organisms rewire their metabolism to adapt to low oxygen levels-such as those found at high altitudes.

19 Feb 2026

Methionine: A dietary key to surviving infection

As soon as you are wounded-whether from grabbing a hot pan or contracting the flu-you begin a unique journey through variable symptoms toward either recovery or death.

22 Jan 2026

Preclinical study reveals potential new treatment for severe liver fibrosis

Researchers at McMaster University are leading preclinical studies into a novel drug candidate developed by Espervita Therapeutics that has the potential to prevent and reverse liver fibrosis - a dangerous, disease-induced build-up of scar tissue in the liver that often leads to cancer.

13 Jan 2026

Obesity study reveals gut fat's unique inflammatory role and immune cell richness

Abdominal fat is not a uniform tissue. A new study from Karolinska Institutet, Steno Diabetes Center Copenhagen, and Helmholtz Munich reveals that fat located close to the large intestine contains an unusually high number of inflammatory fat cells and immune cells.

13 Jan 2026

Digital twin technology guides personalized treatment for brain cancer patients

A new machine-learning-based approach to mapping real-time tumor metabolism in brain cancer patients, developed at the University of Michigan, could help doctors discover which treatment strategies are most likely to be effective against individual cases of glioma.

12 Jan 2026

Metabolic BMI reveals hidden health risks in normal weight individuals

People of normal weight may also be at risk of diabetes and similar diseases. A study from the University of Gothenburg reveals that those with an unexpectedly high so-called metabolic BMI have up to a five times higher risk level.

12 Jan 2026

Natural daylight during office hours improves glucose stability in type 2 diabetes

Natural daylight exposure during office hours improves glucose control and boosts fat oxidation in individuals with type 2 diabetes, enhancing metabolic health.

8 Jan 2026

Why promising microbiome therapies rarely work in patients

Addressing the microbiome's translational gap involves understanding biological complexity and developing function-driven, patient-specific interventions.

8 Jan 2026

Study shows beneficial impact of natural light on people with type 2 diabetes

Metabolic diseases have reached epidemic proportions in our society, driven by a sedentary lifestyle coupled with circadian misalignment - a desynchrony between our intrinsic biological clocks and environmental signals.

7 Jan 2026

A single immune protein may help explain why kidney and heart disease often develop together

This review synthesizes clinical, genetic, and mechanistic evidence showing that suPAR and related uPAR fragments are strongly associated with kidney, cardiovascular, and metabolic disease risk. It highlights suPAR as a stable biomarker of innate immune activation with potential pathogenic roles, while underscoring major gaps in assay standardization and therapeutic validation.

6 Jan 2026

Remodeling the tumor microenvironment to unlock CAR-T cell potential

Chimeric antigen receptor T (CAR-T) cell therapy has revolutionized hematologic cancer treatment, but its efficacy in solid tumors remains limited by poor infiltration into the complex tumor microenvironment (TME).

22 Dec 2025

Specific gut bacterium reduces weight gain and improves metabolic health

The gut microbiome is intimately linked to human health and weight. Differences in the gut microbiome-the bacteria and fungi in the gut-are associated with obesity and weight gain, raising the possibility that changing the microbiome could improve health.

16 Dec 2025

Revolutionary quantum sensors could enable earlier cancer diagnosis and treatment

A revolutionary quantum sensing project that could transform cancer treatment by tracking how immune cells interact with tumors has been awarded a prestigious £2 million Future Leaders Fellowship.

16 Dec 2025

Dietary restriction boosts antitumour immunity by rewiring T cell metabolism

Dietary restriction reshapes CD8+ T cell metabolism by increasing ketone body–driven acetyl-CoA production, preventing terminal exhaustion and enhancing tumour control in mice. This metabolic reprogramming also boosts responsiveness to PD-1 blockade, suggesting a potential strategy to improve cancer immunotherapy.

10 Dec 2025

New atomic structure reveals how NBCn1 transporter protein aids breast cancer cell survival

UCLA scientists have characterized the structure and function of a key survival protein in breast cancer cells that helps explain how these tumors resist environmental stress and thrive in acidic, low-oxygen environments that would normally be toxic to healthy cells.

5 Dec 2025

Obesity-driven estrone emerges as a key driver of deadly postmenopausal breast cancer

A new analysis of research into the most common type of breast cancer has zeroed in on an overlooked hormone that may be responsible for the increased risk of breast cancer death in post-menopausal women with obesity.

2 Dec 2025

Study finds GLP-1 drugs improve strength and reverse aging biology in mice

Researchers showed that GLP-1 receptor agonism counteracts aging across multiple organs in mice, improving strength and reversing molecular aging signatures without meaningful effects on body weight. These benefits depended largely on hypothalamic GLP-1R signaling and closely mirrored the anti-aging patterns produced by rapamycin.

23 Nov 2025