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UAB Research Probes Molecular Basis Of Rare Genetic Disorder

An international group co-led by University of Alabama at Birmingham researcher Mary MacDougall, Ph.D., has unraveled the molecular basis for the rare, inherited genetic disorder, Singleton-Merten Syndrome (SMS). Individuals with SMS develop extreme, life-threatening calcification of the aorta and heart valves, early-onset periodontitis and root resorption of the teeth, decreases in bone density, and loss of bone tissue at the tips of fingers and toes.

23 Jan 2015

Noninvasive laser therapy triggers stem cells to repair enamel of teeth

A Harvard-led team is the first to demonstrate the ability to use low-power light to trigger stem cells inside the body to regenerate tissue, an advance they reported in Science Translational Medicine.

29 May 2014

New bioinspired gel material could help repair damaged teeth and bone

A bit of pressure from a new shrinking, sponge-like gel is all it takes to turn transplanted unspecialized cells into cells that lay down minerals and begin to form teeth.

6 Mar 2014

OrthoTrophix commences TPX-100 Phase 2 clinical study in knee osteoarthritis patients

OrthoTrophix, Inc., a privately held biopharmaceutical company, announced today that the Company started a Phase 2 clinical study of its cartilage repair therapeutic agent, TPX-100, with knee osteoarthritis patients in the U.S. The Company also announced that it had successfully closed the second and last tranche of its Series A preferred stock financing.

20 Feb 2014

Olympic athletes lose to poor dental health

Olympic athletes appear to be at an increased risk of poor dental health, an outcome that may negatively impact on their well being and also on their ability to train and perform, research shows.

1 Oct 2013

Almost 50% percent of population suffers from tooth sensitivity

Almost 50% percent of the population suffers from tooth sensitivity to cold, sweet and hot foods and liquids, according to a nationwide survey of 1,056 adults age 18—65+. Almost half of respondents had tried sensitivity toothpastes, but only about one-third of those found their experience to be positive, noted Larry Fishman, president of Majestic Drug Co., Inc.

2 Aug 2013

Scientists report loss of dental material may be linked to reduction of tooth wear

Scientists of the Max Planck Institute for Evolutionary Anthropology in Leipzig and the Senckenberg Research Institute in Frankfurt together with dental technicians have digitally analysed modern human teeth using an engineering approach, finite element method, to evaluate the biomechanical behaviour of teeth under realistic loading.

25 Apr 2013

Scientists develop new method for replacing missing teeth

Scientists have developed a new method of replacing missing teeth with a bioengineered material generated from a person's own gum cells.

11 Mar 2013

Oral Candida infection weakens tooth enamel

Oral infection with Candida albicans is associated with demineralization of tooth enamel, potentially increasing susceptibility to caries, research shows.

11 Feb 2013

Catenin required in odontoblasts for tooth root formation

Today, the International and American Associations for Dental Research (IADR/AADR) published a paper titled "--catenin is Required in Odontoblasts for Tooth Root Formation." The paper, written by lead authors Tak-Heun Kim and Cheol-Hyeon Bae, Chonbuk National University Korea School of Dentistry, Laboratory for Craniofacial Biology, is published in the IADR/AADR Journal of Dental Research.

23 Jan 2013

Scientists report advance toward preventing tooth sensitivity

Taking inspiration from Mother Nature, scientists are reporting an advance toward preventing the tooth sensitivity that affects millions of people around the world. Their report on development of the substance, similar to the adhesive that mussels use to attach to rocks and other surfaces in water, appears in the journal ACS Applied Materials & Interfaces.

4 Jan 2013

Scientists to develop hydrogels that can be injected into patients to form active biological scaffolds

Smart scaffolding that can guide cells, proteins and small-molecule drugs to make new tissue and repair damage inside the body is in the works at Rice University.

14 Nov 2012

Phantom caries revealed?

Microcomputed tomography of teeth can detect demarcated radiolucencies below the enamel–dentin junction that are of noncarious origin, and can therefore be classified as possible developmental irregularities, show study results.

6 Nov 2012

Partial dentin removal superior to stepwise excavation over long term

Partial caries removal treatment for individuals with deep caries lesions results in significantly improved pulp vitality after 3 years than does stepwise excavation, indicate Brazilian study findings.

1 Nov 2012

Age impacts salivary markers of oxidative stress, oral pathology

Age has a significant impact on the variance of salivary markers of oxidative stress, and could shed light on the pathogenesis of oral diseases, report Slovakian researchers.

4 Oct 2012

New JEBDP series provides updates on evidence-based care in periodontics and implant dentistry

What's the latest, research-supported best practice in periodontal care and implant dentistry? Dental specialists and generalists alike can read about it in the first of a new series from The Journal of Evidence-Based Dental Practice (JEBDP), the foremost publication of information about evidence-based dental practice, published by Elsevier.

4 Oct 2012

Long-term study shows effectiveness of fissure sealing

Sealing pits and fissures with a resin-based material can arrest the progression of noncavitated dentinal occlusal caries, show results of a 36-month clinical trial.

10 Jul 2012

Odontoblast cells are part of immune system, protect teeth from decay: New research

It is known that teeth can protect themselves, to some extent, from attack by bacteria but that inflammation within a tooth can be damaging and, in extreme cases, lead to abscess or death of the tooth. New research published in BioMed Central's open access journal BMC Immunology shows that odontoblast cells are part of the immune system and fight to protect teeth from decay.

23 Jan 2011

New study reveals potential role of TGF-β1 in kidney disease

Fibrosis in the kidney is one of the key causes of progressive renal failure. High levels of the inflammatory molecule TGF-β1 in the kidney tubules due to tissue damage can cause fibrosis as well as nephron degeneration, resulting in loss of kidney function. To clarify the mechanisms regulating TGF-β1-mediated renal fibrosis, Koesters et al expressed high levels of TGF-β1 in renal tubules of mice. Nephron degeneration in this system was mediated by decomposition of the tubular cells. These data suggest that TGF-β1 may play a novel role in cell death of renal cells, thus contributing to renal fibrosis.

28 Jul 2010

New REMESENSE TOOTH DESENSITIZER for treating tooth hypersensitivity

Nuline Pharmaceuticals, LLC announces the introduction of REMESENSE (dipotassium oxalate 3%) TOOTH DESENSITIZER, an Rx Class II medical device now available in the U.S. REMESENSE was introduced globally in 2008. It is presently sold in 16 countries, ranging from England and the European Union to Asia and Africa. Nuline expects to launch REMESENSE in Canada and other countries later this year or by early 2011.

15 Jul 2010