Glucocorticoid News and Research

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Glucocorticoid is a compound that belongs to the family of compounds called corticosteroids (steroids). Glucocorticoids affect metabolism and have anti-inflammatory and immunosuppressive effects. They may be naturally produced (hormones) or synthetic (drugs).

Study offers a potential new strategy to improve treatment responses in multiple myeloma patients

Researchers at the VIB-UGent Center for Medical Biotechnology have discovered a promising strategy to improve treatment responses in multiple myeloma patients by blocking a protein that plays a key role in drug resistance.

15 Apr 2025

New research sheds light on prostate cancer resistance mechanisms

According to the American Cancer Society, approximately 1 in 8 men in the U.S. will be diagnosed with prostate cancer during their lifetime.

27 Mar 2025

Chronic stress rewires the brain, dulling sound perception

Repeated stress disrupts auditory processing, making sounds seem quieter over time, as shown in a new study on mice.

17 Feb 2025

Diabetes medications may help lower COPD flare-up risk, study finds

The study reveals SGLT-2is are linked to fewer COPD exacerbations in type 2 diabetes, suggesting a need for further clinical trials to confirm these findings.

11 Feb 2025

Maternal stress in early pregnancy affects long-term health of offspring

Maternal stress hormone levels during early pregnancy can have a lasting effect on the stress system of the offspring.

22 Jan 2025

Annona squamosa extracts show promise in treating pain and arthritis

In Brazil, researchers have identified substances with analgesic, anti-inflammatory, anti-hyperalgesic (against persistent pain) and anti-arthritic activity in the leaves of Annona squamosa, a tree popularly known in the country as fruta-do-conde or pinha.

20 Dec 2024

Brain tumors exploit body's daily rhythms to fuel growth

Scientists explore how daily glucocorticoid signaling influences glioblastoma growth and synchronizes its circadian rhythms with the host.

18 Dec 2024

Disrupting the circadian rhythm of glioblastoma slows tumor growth, study says

Virtually every cell in the human body has an internal clock. These clocks take their cues from a central clock in the brain. In a normal, biological process called synchrony, the central clock coordinates daily rhythms around the body, so that every cell and tissue recognizes the same external time of day.

13 Dec 2024

Steritas announces collaboration with argenx to advance evidence for novel steroid-sparing therapeutics

Steritas LLC., a company dedicated to enhancing care for steroid-treated patients, today announced a licensing agreement with argenx, a global immunology company, for use of its STOX® Suite of steroid-toxicity clinical outcome assessments (COAs) across argenx's development programs for differentiated immunology therapeutics.

From Steritas LLC 25 Nov 2024

New study links circadian gene variants to winter depression

Variants of the PER3 gene disrupt adrenal adaptation to winter light, leading to serotonin disruption and depression-like behaviors in humanized mice models.

13 Nov 2024

How gut bacteria regulate stress and sleep cycles

This study reveals that gut microbiota, particularly Lactobacillus species, regulate the daily rhythm of stress hormones like corticosterone, influencing stress responses and brain function at different times of the day. Disruptions in gut bacteria lead to altered stress responses and increased susceptibility to disorders like depression.

10 Nov 2024

Lupus Research Alliance launches first Translational Bridge Award to accelerate lupus treatments

The Lupus Research Alliance (LRA) is excited to announce the first-ever recipients of the Translational Bridge Award (TBA), established this year to accelerate the translation of groundbreaking research into potential treatments and diagnostics for lupus.

8 Nov 2024

Emerging therapies transform autoimmune hepatitis treatment approaches

Autoimmune hepatitis (AIH) is a chronic, progressive liver disease caused by immune system dysregulation that targets the liver. If untreated, AIH can lead to severe complications, including cirrhosis and liver failure.

6 Nov 2024

Study uncovers key role of gut microbiota in regulating stress responses

A pioneering study has uncovered the vital role that gut microbiota plays in regulating stress responses by interacting with the body's circadian rhythms.

5 Nov 2024

Curcumin shows promise in preventing and treating oral submucosal fibrosis

Researchers explore the mechanisms, therapeutic potential, and clinical applications of curcumin in preventing and treating oral submucosal fibrosis.

30 Oct 2024

Professor Vicki Clifton shares discoveries about placenta's influence on maternal mental health

In a revealing Genomic Press Interview published in Brain Medicine on October 29, 2024, Professor Vicki Clifton shares transformative discoveries about the placenta's unexpected influence on maternal mental health, potentially revolutionizing our understanding of pregnancy-related anxiety and depression.

29 Oct 2024

Low-carb diet may improve beta-cell function in type 2 diabetes patients

This study shows a carbohydrate-restricted diet boosts β-cell function in type 2 diabetes, offering a sustainable approach to manage the disease effectively.

24 Oct 2024

The new science behind the health benefits of caffeine

A study reveals caffeine's potential to enhance heart health by improving endothelial function in systemic lupus erythematosus patients through EPC survival.

9 Oct 2024

Inflammatory proteins linked to higher risk of endometrial cancer

Study identifies key inflammatory and immune response proteins linked to endometrial cancer risk through both observational and Mendelian Randomization analyses, revealing the roles of IL-6 and HSD11B1.

1 Oct 2024

Steritas' Pediatric Glucocorticoid Toxicity Index applied in clinical trial to assess steroid-toxicity

Steritas LLC., a company dedicated to enhancing patient care for steroid-treated patients announced that Alder Hey Children’s NHS Foundation Trust, and the Liverpool Clinical Trials Centre will apply its Steritas Pediatric Glucocorticoid Toxicity Index (pGTI) in a clinical trial to compare efficacy, safety and cost-effectiveness of intravenous versus oral glucocorticoids (steroids) for children and young people with Juvenile Idiopathic Arthritis (JIA).

From Steritas LLC 25 Sep 2024