Gluconeogenesis News and Research

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Gluconeogenesis (abbreviated GNG) is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as lactate, glycerol, and glucogenic amino acids.

Reversing β-cell failure: A promising approach for type 2 diabetes treatment

Researchers examined current evidence on the reasons and implications of pancreatic beta-cell failure.

3 Aug 2023

Study provides new insights into how SARS-CoV-2 affects glucose metabolism

Research conducted at the University of São Paulo (USP) in Brazil shows that SARS-CoV-2, the virus that causes COVID-19, can infect liver cells (hepatocytes), stimulating glucose production and leading to a condition similar to diabetes (hyperglycemia) in hospitalized patients, even if their blood sugar level was normal before they were admitted to hospital.

19 Jul 2023

One-day keto diet boosts energy expenditure, exogenous ketones have little effect

Research aims to compare the effects of a one-day isocaloric ketogenic diet, fasting, and supplementation with ketone salts on energy expenditure and appetite perception. The study found that a 24-hour ketogenic diet may contribute to maintaining a neutral energy balance by increasing energy expenditure.

29 May 2023

Surviving without glucose: uridine-derived ribose as an alternative energy source

Researchers attempted to identify new genes and molecular pathways that might supply energy when the availability of glucose or other nutrients is limited.

22 May 2023

Researchers find that SARS-CoV-2 directly infects hepatocytes that cause hyperglycemia

Researchers investigate whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused hyperglycemia.

18 May 2023

Boosting gut health with short-chain fatty acids

Research paper provides an overview of short-chain fatty acids (SCFAs) and their role in regulating gut homeostasis. It also discusses SCFA-producing bacteria and potential therapeutic approaches to boost SCFA levels in the gut to treat related diseases.

9 May 2023

Researchers discover a key player in preventing 'insulin shock'

Just over a century has passed since the discovery of insulin, a time period during which the therapeutic powers of the hormone have broadened and refined. Insulin is an essential treatment for type 1 diabetes and often for type 2 diabetes, as well.

24 Apr 2023

Proper nutrition could boost recovery from traumatic brain injury

In the first few days after a traumatic brain injury (TBI), food is often an afterthought as clinicians focus on minimizing the damage to the brain.

21 Apr 2023

24 hour ketogenic diet increases energy expenditure, ketone supplements show little effect

In a recent study published in the journal Clinical Nutrition ESPEN, researchers compared the effects of fasting, ketone salt supplementation, and a one-day isocaloric ketogenic diet on the appetite perception and energy expenditure of healthy adults.

12 Apr 2023

Do seasonal changes in food types lead to changes in the composition and structure of gut microbiota?

Researchers assessed the impact of diet or macronutrient consumption on the function and structure of gut microbiota.

6 Mar 2023

Weight loss in obese subjects could reverse type 2 diabetes progression

A new paper explains a model of diabetes that centers on the role of obesity in glucose dysregulation.

28 Feb 2023

What is the association between diabetes and SARS-CoV-2 infections?

Researchers explored whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can expedite or trigger the development of diabetes mellitus (DM).

15 Nov 2022

Do hypertension, dyslipidemia, and new-onset diabetes mellitus play a part in post-COVID sequelae?

A new study evaluated the current research on incidences of hypertension, new-onset diabetes mellitus, and dyslipidemia as possible sequelae of coronavirus disease 2019 (COVID-19).

18 Oct 2022

Routine periodic fasting associated with lower hospitalization risk in patients with COVID-19

The main objective of a new prospective observational cohort study was to evaluate whether periodic fasting is linked with severe COVID-19 symptoms.

1 Aug 2022

Researchers explore the fate of dietary fructose in the body

In today's fast-paced world, the dependence on the widely available "fast" foods and beverages has risen. These foods are typically low in fiber and essential nutrients, and often consist of high amounts of added sugar. This shift in dietary trends, accompanied by a sedentary lifestyle, has been attributed to the rise in various metabolic disorders like diabetes, fatty liver disease, and heart disease.

31 Aug 2021

SARS-CoV-2 modulates host cell central carbon metabolism for reproduction

A team of scientists from Sweden and India has recently characterized the host cell metabolic alterations associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Their findings reveal that SARS-CoV-2 modulates the host cell's central carbon metabolism to facilitate replication and infection propagation.

28 Feb 2021

A practical guide to critical parameters in acute care testing

The acute care testing handbook is a practical guide to critical parameters in acute care testing such as pO2, lactate and troponin.

From Radiometer Medical 24 Feb 2021

Yale discovery has implications for treatment of diabetes and non-alcoholic fatty liver disease

Many health problems in the developed world stem from the disruption of a delicate metabolic balance between glucose production and energy utilization in the liver.

4 Mar 2020

Physical exercise can reduce liver fat, improve blood sugar control in obese individuals

Research conducted at the University of Campinas in São Paulo State, Brazil, shows that vigorous physical exercise such as strength and weight training can reduce accumulated liver fat and improve blood sugar control in obese and diabetic individuals in a short time span, even before significant weight loss occurs.

13 Jun 2019

Study investigates the role of estrogen in controlling glucose homeostasis

The results of a recent Texas A&M University-led study provide insights into the mechanism by which estrogen can decrease insulin resistance and the production of glucose, reducing incidences of Type 2 diabetes mellitus.

13 Feb 2019