Liquid Chromatography News and Research

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Alexandra Knauer receives the Pittcon Heritage Award

Entrepreneur Alexandra Knauer, managing director of lab instrument manufacturer KNAUER, is honored in the USA with the Pittcon Heritage Award 2026.

From KNAUER Wissenschaftliche Geräte GmbH 10 Mar 2026

Specific gut bacteria may signal long-term risk of heart and metabolic disease

Researchers analyzed gut microbiome profiles from 4,792 adults in the HELIUS cohort and tracked cardiometabolic outcomes over time to determine whether specific microbes predict disease risk. Certain microbes were linked to higher or lower cardiovascular risk, while plant-derived microbial metabolites suggested potential diet–microbiome interactions influencing heart health.

9 Mar 2026

Colorful japonica rice varieties show unique health-promoting lipids

Rice feeds more than half of the world's population, yet we still only partly understand the nutrients it contains.

27 Feb 2026

Pomegranate’s hidden fiber-bound polyphenols significantly increase total antioxidant capacity

Researchers showed that pomegranate fruit extract contains substantial levels of non-extractable polyphenols bound within its fibre-rich matrix, significantly increasing its total measured antioxidant capacity. In human neuronal and astrocytic cell lines, the extract reduced hydrogen peroxide–induced oxidative stress, particularly in astrocytes, under in vitro conditions.

26 Feb 2026

Researchers show red blood cells drive better glucose tolerance at high altitude

Chronic hypoxia improves glucose tolerance in mice through insulin-independent mechanisms, with red blood cells acting as a major systemic glucose sink. Increased erythrocyte production and altered glycolytic flux help reduce circulating glucose while supporting oxygen delivery to tissues.

22 Feb 2026

Blood test models predict when Alzheimer’s symptoms may start years in advance

Researchers developed plasma p-tau217–based clock models that estimate when cognitively unimpaired individuals with Alzheimer’s pathology may develop symptomatic disease. The models predicted symptom onset within about three to four years and may help improve clinical trial selection while remaining unsuitable for individual clinical decisions at present.

22 Feb 2026

Toxic compounds found in synthetic and natural hair extensions

Chemical analysis of hair extensions uncovers hazardous substances, emphasizing the need for improved regulation and transparency in the beauty industry.

16 Feb 2026

Nasal COVID vaccine boost increases IgA responses linked to variant neutralisation

Intranasal boosting after prior intramuscular COVID vaccination induced strong mucosal IgA responses in a small human cohort. These antibodies showed markedly enhanced neutralising activity against Omicron variants and evidence of immune memory reprogramming toward mucosal protection.

15 Feb 2026

Ageing slows brain protein clearance and shifts synaptic waste to microglia

Ageing slows neuronal protein degradation in mice, leading to widespread accumulation and aggregation of long-lived proteins, particularly at synapses. As neuronal clearance declines, microglia selectively accumulate synaptic proteins, suggesting a compensatory but potentially strained proteostasis pathway in the ageing brain.

22 Jan 2026

Blood metabolite profiling outperforms BMI in predicting pregnancy complications

This study shows that a blood-based metabolomic signature linked to maternal BMI predicts gestational diabetes and preeclampsia more strongly than BMI alone, particularly in late pregnancy. A subset of 16 metabolites statistically mediates the BMI–gestational diabetes association, highlighting metabolic pathways that may improve prenatal risk stratification.

21 Dec 2025

Sterilized fermented beverage targets obesity and type 2 diabetes pathways in computational study

Researchers profiled a terminally sterilized probiotic-fermented MFH beverage and identified aporphine alkaloids and flavonoids with favorable predicted ADMET properties. Integrated network pharmacology, molecular docking, and 100-ns MD simulations suggest multi-target engagement of metabolic-inflammatory pathways relevant to obesity and type 2 diabetes.

9 Dec 2025

Supportive marriages may shape appetite control through oxytocin and the brain–gut axis

Supportive marital relationships are associated with lower BMI, fewer food addiction symptoms, higher oxytocin, stronger frontal brain responses to food cues, and favorable gut tryptophan metabolites. These coordinated social, neural, hormonal, and gut pathways suggest a plausible biological link between emotional support and healthier eating regulation.

8 Dec 2025

Sweat testing could transform drug monitoring and diabetes care

Innovative sweat sampling techniques could revolutionize diagnostics, offering insights into glucose levels and environmental toxins with minimal discomfort.

4 Dec 2025

Chronic drinking weakens the blood-brain barrier through the gut

Chronic alcohol consumption disrupts the blood-brain barrier, but Faecalibacterium prausnitzii shows promise in repairing this damage and improving cognition.

27 Nov 2025

Switching APOE4 to APOE2 in adult mice reduces Alzheimer’s pathology and improves memory

Replacing APOE4 with APOE2 in adult mice rapidly reshapes brain lipids and gene expression, even after development is complete. This switch, especially when targeted to astrocytes, reduces amyloid burden, dampens gliosis, and improves associative memory despite E2-like peripheral lipid risks.

12 Nov 2025

Low-cost biosensor identifies altered protein levels associated with psychiatric disorders

Brazilian researchers have developed a low-cost, portable biosensor that can quickly identify a protein whose altered levels are associated with psychiatric disorders, such as depression, schizophrenia, and bipolar disorder.

30 Oct 2025

Can strawberries help prevent diabetes? New trial shows promising results in prediabetic adults

Daily consumption of freeze-dried strawberries for 12 weeks improved antioxidant defense, reduced inflammation, and lowered fasting glucose in adults with prediabetes. The randomized crossover trial highlights strawberries’ potential as a simple, food-based strategy to enhance metabolic and vascular health.

21 Oct 2025

Liquid Chromatography News and Research

Alexandra Knauer receives the Pittcon Heritage Award

Specific gut bacteria may signal long-term risk of heart and metabolic disease

Colorful japonica rice varieties show unique health-promoting lipids

Pomegranate’s hidden fiber-bound polyphenols significantly increase total antioxidant capacity

Researchers show red blood cells drive better glucose tolerance at high altitude

Blood test models predict when Alzheimer’s symptoms may start years in advance

Toxic compounds found in synthetic and natural hair extensions

Nasal COVID vaccine boost increases IgA responses linked to variant neutralisation

Ageing slows brain protein clearance and shifts synaptic waste to microglia

Blood metabolite profiling outperforms BMI in predicting pregnancy complications

Sterilized fermented beverage targets obesity and type 2 diabetes pathways in computational study

Supportive marriages may shape appetite control through oxytocin and the brain–gut axis

Sweat testing could transform drug monitoring and diabetes care

Chronic drinking weakens the blood-brain barrier through the gut

Switching APOE4 to APOE2 in adult mice reduces Alzheimer’s pathology and improves memory

Low-cost biosensor identifies altered protein levels associated with psychiatric disorders

Can strawberries help prevent diabetes? New trial shows promising results in prediabetic adults

Why protein powders can secretly cause doping bans

Toxic e-waste pollution linked to rising childhood hypertension

Common food additives may trigger childhood asthma

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