Malignant News and Research

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New study frames altered protein modifications as cancer drivers

Cancer has often been explained through mutations in deoxyribonucleic acid (DNA) or changes in ribonucleic acid (RNA), but these layers do not fully explain why tumors with similar genetic profiles can behave differently.

9 Jun 2026

Houston researcher identifies new targets for fatal rhabdomyosarcoma

A cancer researcher at the University of Houston is reporting what makes malignant soft tissue cancer grow in children, identifying key mechanisms and molecular targets to prevent tumor progression in patients in future therapies of the fatal rhabdomyosarcoma.

9 Jun 2026

Review highlights TIGIT as a promising second-generation immunotherapy target

Malignant tumors remain a major threat to human health, with conventional therapies and first-generation immune checkpoint inhibitors (ICIs) facing limitations like drug resistance and low response rates.

5 Jun 2026

Amplified Sciences secures investment for pancreatic cyst diagnostic assay

Amplified Sciences, a clinical-stage diagnostics company pioneering next-generation multi-omic assays, today announced a new investment from the American Gastroenterological Association's (AGA) GI Opportunity Fund as part of its recent Seed+ financing round.

4 Jun 2026

Case report highlights diagnostic features of rare eyelid sebaceous adenoma

A new case report was published in Volume 13 of Oncoscience on April 2, 2026, titled "Sebaceous adenoma of the eyelid: A clinical, histopathological, and immunohistochemical perspective."

4 Jun 2026

Diverse cancer subtypes can originate from a single progenitor cell

How do different cancer subtypes arise? Do they originate from distinct cells, or from a single multipotent cell capable of differentiating into multiple cell types?

4 Jun 2026

Brain remodeling bypasses the prefrontal bottleneck to automate complex skills

New research by Georgetown scientists shows how the brain rewires itself to automate learned tasks. The findings challenge a long-held understanding of how humans master complex skills, suggesting that true multitasking is really possible.

4 Jun 2026

New PET imaging platform improves osteosarcoma surgery precision

A new end-to-end PET imaging approach for osteosarcoma can rapidly and reliably distinguish tumor tissue from normal tissue and accurately assess surgical margins in real time.

2 Jun 2026

Lifestyle habits predict long-term health better than cancer treatment history

Healthy lifestyle habits are crucial for childhood cancer survivors, reducing risks of chronic conditions and improving quality of life more than treatments.

2 Jun 2026

Mature intestinal cells regain stem cell behavior to trigger tumor growth

In a groundbreaking study, Stevens researchers show how colorectal cancers can evolve from mature intestinal cells that revert to stem cells.

1 Jun 2026

Hypoxia-gated AAV enables targeted treatment for advanced NSCLC

Adeno‑associated virus (AAV) vectors offer safety and durable expression but lack tumor specificity. This hypothesis proposes an NSCLC‑directed, hypoxia‑responsive AAV platform that integrates MGS4 peptide‑guided capsid targeting with dual hypoxia‑responsive element (HRE)‑gated promoters driving Q‑CXCL9‑Fc (chemokine) and miR‑30‑based shRNA against mesothelin (MSLN).

1 Jun 2026

Study reveals right ventricle better tolerates oxygen loss during cardiac arrest

A study led by scientists at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) provides new insights into ventricular fibrillation (VF), the most dangerous type of cardiac arrhythmia.

29 May 2026

Gut changes linger years after polyp removal and may signal colorectal cancer risk

Researchers found that women who had undergone colorectal adenoma resection still showed gut microbiome and fecal metabolome alterations an average of about 12 years later. These persistent changes partly resembled colorectal cancer-associated patterns, suggesting that the host-microbiome axis may remain altered along the adenoma-cancer continuum.

28 May 2026

Scientists target root of relapse in aggressive childhood brain tumors

Stopping cancer from coming back is the goal of new research from MUSC Hollings Cancer Center, where scientists are targeting cells that fuel the return of an aggressive pediatric brain tumor.

26 May 2026

Researchers identify unique genetic signature in rare oral cancer

Cancer diagnosis can be challenging, and delayed diagnosis can allow cancer to progress, complicating treatment.

26 May 2026

Scientists reveal why common pancreatic precancer lesions rarely turn deadly

Spatial and single-cell analyses of human donor pancreata showed that PanIN epithelial cells gradually acquire cancer-like molecular features, while their surrounding stromal and immune environment remains closer to normal pancreatic tissue. The findings suggest that delayed or incomplete microenvironmental reprogramming may help explain why most PanIN lesions remain indolent rather than progressing to pancreatic cancer.

24 May 2026