Malignant News and Research

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New microfluidic chip predicts personalized glioblastoma treatment responses

Even for the same brain tumor treated with the same anticancer drug, the effect can differ from patient to patient.

17 Aug 2026

Dual-phase deep learning models improve pancreatic cyst risk assessment

Pancreatic cystic lesions are being found more frequently as cross-sectional imaging becomes more common.

17 Aug 2026

Personalized T-cell therapy eliminates advanced kidney tumor in teenager

Researchers and physicians at the Hopp Children's Cancer Center Heidelberg (KiTZ) and other leading cancer centers report an exceptional treatment success in an adolescent with an advanced, therapy-resistant kidney tumor.

12 Aug 2026

Integrated nanomaterials offer new strategies for cancer immunotherapy

Immune checkpoint inhibitors, cancer vaccines and cellular therapies have reshaped oncology, yet most patients still do not achieve lasting benefit.

9 Aug 2026

Patient-derived tumor models strengthen precision oncology research

A research project funded by the National Institutes of Health (NIH), with collaborators around the country and the world, has generated one of the most extensive and diverse collections of patient-derived tumor models.

5 Aug 2026

Targeted dendritic cell vaccines emerge as a major step forward in cancer immunotherapy

A major step forward in cancer immunotherapy is emerging through the growing development of dendritic cell vaccines, a highly targeted approach designed to harness the body's own immune system to fight tumors.

5 Aug 2026

Insilico Medicine highlights AI-powered biological target discovery for rare sinonasal cancer

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven biotechnology company, today announced the publication of a collaborative study in the journal npj Precision Oncology.

4 Aug 2026

QUANTUM trial tests immune-targeting approach for primary plasma cell leukemia

The Alliance for Clinical Trials in Oncology today announced the activation of The QUANTUM Trial (Alliance A062401), a clinical study designed to test a novel, immune-targeting approach for patients newly diagnosed with primary plasma cell leukemia (PCL).

30 Jul 2026

FDA grants fast track designation to Insilico's AI-designed mesothelioma drug candidate

Insilico Medicine ("Insilico"; HKEX: 3696), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, today announced that ISM6331, a novel, potential best-in-class pan-TEAD inhibitor driven by Insilico's proprietary AI, has received Fast Track Designation (FTD) from the U.S.

29 Jul 2026

New human tissue model tracks aggressive brain tumor infiltration

Glioblastoma is an aggressive brain tumor that infiltrates deep into the surrounding brain tissue. Even after surgery, tumor cells remain in the brain and the tumor recurs.

28 Jul 2026

Two heart nerve cell types sustain cardiac stability in mice

Researchers identified two major intrinsic cardiac neuron populations in mice: Npy-positive neurons regulate parasympathetic heart rate control and support coronary perfusion, while Ddah1-positive neurons help maintain electrical stability during extreme stress. Removing Npy-positive neurons caused fatal cardiac failure, whereas loss of Ddah1-positive neurons increased susceptibility to malignant arrhythmias and sudden cardiac arrest under stress.

23 Jul 2026

Genetic background shapes cancer development despite identical risk factors

Why do cancers develop differently in different people-even when they are exposed to the same risk factors? An international research group, including the German Cancer Research Center (DKFZ), has now demonstrated in mice that an organism's genetic makeup significantly influences the course of cancer development.

22 Jul 2026

Occult hepatitis B mutations drive liver cancer growth via Akt mTOR pathway

Occult hepatitis B virus (OBI) infection presents a significant global health challenge, notoriously flying under the radar of standard viral screening while relentlessly driving the pathogenesis of hepatocellular carcinoma (HCC).

22 Jul 2026

Red meat intake emerges as a potential pancreatic cancer risk factor

A systematic review and meta-analysis of 16 studies involving nearly 2 million participants found that higher red meat intake was associated with a modestly higher risk of pancreatic cancer. Processed meat intake showed no statistically significant association, although variation between studies means a small effect cannot be excluded.

22 Jul 2026

UVA researchers develop a new experimental approach to target glioblastoma

University of Virginia Comprehensive Cancer Center scientists have developed a promising new experimental approach to targeting glioblastoma, the most common and deadliest brain cancer.

22 Jul 2026

City of Hope launches trial to map how tumors change during immunotherapy resistance

City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the United States with its National Medical Center ranked among the nation's top cancer centers by U.S. News & World Report, has opened an innovative Phase 2 clinical trial designed to map how tumors change as they begin to resist immunotherapy, treatment that improves the immune system's ability to fight disease.

21 Jul 2026

New BRAF protein conformation opens avenues for cancer treatment

Several types of cancer are triggered by mutations in a protein called BRAF. Researchers at the Paul Scherrer Institute PSI have resolved a previously unknown conformation adopted by this protein during cell proliferation.

21 Jul 2026

AI-guided technique improves targeted therapy delivery for brain tumors

Researchers presented a groundbreaking artificial intelligence (AI)-guided technique today at the Society of NeuroInterventional Surgery's (SNIS) 23rd Annual Meeting that may improve the accuracy of delivering experimental therapies directly to malignant brain tumors.

20 Jul 2026

KAIST study opens a new avenue for treating intractable brain tumors

Researchers have uncovered a clue to why immune checkpoint inhibitors-cancer therapies that release the immune "brakes" exploited by tumors to evade attack-show limited efficacy in some brain tumors.

19 Jul 2026

Blood-based gene tests show promise for pancreatic cancer screening

Researchers at Kanazawa University report the blood-based gene expression tests may enable early pancreatic cancer screening and improve long-term survival.

16 Jul 2026