Mast Cell News and Research

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Mast cell receptor linked to alcohol withdrawal-associated headaches

Researchers investigate the role of the mast-cell-specific receptor Mas-related G-protein-coupled receptor B2 (MrgprB2) in alcohol-withdrawal-induced headaches.

2 Nov 2023

Scientists identify mechanism of alcohol withdrawal headaches

About 283 million people worldwide suffer from alcohol use disorder, a debilitating health challenge for which limited therapeutic options are available. The cost to society is estimated at greater than $2 trillion annually.

30 Oct 2023

Mapping the mysteries: Study reveals surprising hubs of human immune cells

Researchers in Israel comprehensively mapped the distribution and mass of primary immune cells across human tissues. This groundbreaking study, using advanced biotechnological methods, provides insights into the immune system's cellular network, challenging existing notions and emphasizing the bone marrow, lymph nodes, and spleen as primary immune cell reservoirs.

24 Oct 2023

Mount Sinai secures $6.2 million grant to expand the Cohen Center for Recovery From Complex Chronic Illnesses

Mount Sinai's Department of Rehabilitation and Human Performance has announced a $6.2 million grant from the Steven & Alexandra Cohen Foundation.

20 Sep 2023

New study reveals mast cells' surprising role in allergy-related avoidance behavior

Researchers showed that mast cells and IgE are the key orchestrators of antigen-specific avoidance.

14 Jul 2023

IL-9 identified as contributor to viral spread and airway inflammation in COVID-19

Researchers used a K18-hACE2 transgenic (ACE2.Tg) mouse model to demonstrate that interleukin-9 (IL-9).

13 Jul 2023

Mast cells act as sensors to help avoid harmful antigens

The function of mast cells, which are part of the immune system, is still a mystery. Scientists at the German Cancer Research Center (DKFZ) have now shown in mice: mast cells function as a sensor that signals the animals to avoid antigens, including harmful allergens, and thereby protect themselves from health-threatening inflammatory reactions.

12 Jul 2023

The immunopathology of post-acute sequelae of SARS-CoV-2 infection: highlighting the knowledge gaps

The immunopathology of post-acute sequelae of SARS-CoV-2 infection (PASC).

31 May 2023

Mast cells play a crucial role in the development of chronic myeloid leukemia

Chronic myeloid leukemia (CML) is a type of blood cancer that arises from malignant changes in blood-forming cells of the bone marrow.

16 May 2023

Protein inhibition could offer new strategies for treating severe asthma

Inhibiting a protein on the surface of immune cells could offer new strategies for treating severe asthma, Cleveland Clinic researchers found.

10 May 2023

An exploration of the pathophysiological factors and abnormalities of coagulation of long-COVID

Researchers explored the pathophysiological variables and coagulation abnormalities associated with long coronavirus disease (COVID).

21 Apr 2023

People with asthma or eczema more likely to develop osteoarthritis

Stanford Medicine scientists and their colleagues have found that having asthma or eczema increases the likelihood of developing osteoarthritis — signaling that there may be an allergic pathway that can be targeted with existing drugs.

28 Mar 2023

Pipetting solutions aid allergy prevention research

Researchers at Uppsala University in Sweden are using Integra Biosciences’ PIPETBOY pro pipette controllers with integrated LED lighting to study the physiological function of mast cells and their role in allergic reactions.

From INTEGRA Biosciences 9 Mar 2023

Researchers find a way to block anaphylaxis caused by peanut allergies

Researchers from Indiana University School of Medicine have found a way to block anaphylaxis caused by peanut allergies.

9 Feb 2023

Study reviews mechanistic data on new methods of allergy prevention and treatment

In a recent article published in Science Translational Medicine, researchers reviewed the cause and the underlying pathophysiology of allergic diseases.

23 Jan 2023

What are the major findings of long COVID research?

Researchers explored existing literature on long coronavirus disease (COVID). They highlighted key immunological findings, similarities with other diseases, symptoms, and associated pathophysiological mechanisms, and diagnostic and therapeutic options, including COVID-19 vaccinations.

17 Jan 2023

Does the immunization order of vaccine types influence the efficacy of heterologous prime-boost vaccination, especially mRNA and protein-based vaccines?

A new study aimed to analyze whether the order of immunization of vaccine types impacted the efficacy of a heterologous prime-boost vaccination strategy.

6 Jan 2023