Mutation News and Research

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Giant-nucleus cells form the foundation of early-stage cancer

Iron is an essential micronutrient, but excess iron can damage cells and increase cancer risk. While many cells die from iron-induced oxidative stress, a subset survives and may become cancerous.

11 Sep 2026

Cancer treatments alter the landscape of genetic mutations in healthy body tissues

Cancer treatments, including chemotherapy and radiotherapy, give a growth advantage to cells with particular genetic changes in healthy tissue, new research finds.

11 Sep 2026

Yourgene Health launches Insight DPYD assay (IVDR)

Yourgene Health (part of the Novacyt Group), an international molecular diagnostics company with a broad portfolio of integrated technologies and services, announces the commercial launch of its In Vitro Diagnostic Regulation (IVDR)-certified Yourgene® Insight DPYD assay, expanding the Company's clinical genetics portfolio across regulated European markets.

From Yourgene Health 9 Sep 2026

New base editing techniques accurately modify genes in human embryos

A study by researchers at Columbia University Vagelos College of Physicians and Surgeons has found that new cutting-edge techniques can accurately edit genes in human embryos-giving scientists indispensable tools for understanding normal human development-but has also uncovered important risks that currently preclude the use of the techniques in the clinic.

9 Sep 2026

New genetic map helps track aggressive prostate cancer development

Prostate cancer is the second most common form of cancer among men globally. Yet, we still know relatively little about why the disease develops or why some men live with it for years while in others it progresses aggressively.

9 Sep 2026

Caloric restriction reduces genetic mutations across the mouse genome

Mutations are changes in the molecular "letters" that make up DNA, the genetic blueprint for cells. Mutations build up with age in every cell when DNA is damaged or when cells make mistakes in fixing or copying it.

9 Sep 2026

New prostate cancer screening advances improve early detection

Did you know that about 1 in 8 men will be diagnosed with prostate cancer during their lifetime? According to the American Cancer Society, it remains the second-leading cause of cancer death among American men.

6 Sep 2026

Researchers uncover how Atg2 drives autophagosome formation

Autophagy is an intracellular degradation mechanism in eukaryotes. The autophagosome, which encloses damaged or excess cellular material for degradation, is constructed from lipids supplied by the endoplasmic reticulum (ER), via the lipid transfer protein Atg2.

4 Sep 2026

Crucial brain stem cells rely on metabolic pathways to make decisions

As the human brain takes shape before birth, a remarkable type of stem cell helps give it many of the features that make it distinctly human.

4 Sep 2026

Study finds biases in tools predicting dangerous genetic mutations

When a patient has their DNA read, it gets compared against a reference version of the human genome. It allows geneticists and rare disease experts to look at a list of places where the patient's DNA differs.

3 Sep 2026

New drug class shows major promise for shrinking nerve tumors

A scientist at Cincinnati Children's who has hunted for decades for ways to shrink the painful and disfiguring nerve tumors caused by neurofibromatosis type 1 (NF1) has made a new breakthrough in the quest.

2 Sep 2026

Two scientists win Horwitz Prize for Rett syndrome breakthrough

Columbia University will award the 2026 Louisa Gross Horwitz Prize to Adrian Bird and Huda Zoghbi for their pioneering work on epigenetic regulation in the nervous system and its role in human neurological disease, particularly Rett syndrome.

2 Sep 2026

Nanoparticle flu vaccine design could pave way for broader protection

Influenza viruses constantly shapeshift to evade recognition by the immune system. This shapeshifting occurs in critical proteins like hemagglutinin (HA), which controls how the virus attaches to human cells before entering them.

2 Sep 2026

Study uncovers cause of abnormal breathing in Rett syndrome

Hyperventilating. Breath holding until they turn blue. This abnormal breathing is frequent and disturbing in people with Rett syndrome, a rare genetic disease.

1 Sep 2026

Review highlights challenges in managing childhood enterovirus infections

Enteroviruses (EVs) are a diverse group of viruses and a common cause of multiple infections in children.

1 Sep 2026

FDA approves daraxonrasib for metastatic pancreatic cancer following landmark clinical trial led by Dana-Farber

The U.S. Food and Drug Administration (FDA) has approved daraxonrasib, an oral multi-selective RAS(ON) inhibitor, for adults with metastatic pancreatic adenocarcinoma who have received at least one prior systemic therapy or are not candidates for multiagent systemic therapy.

From Dana-Farber Cancer Institute, Inc. 29 Aug 2026