Neurodegenerative Disorder News and Research

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Genetic analysis of blood sample could offer a non-invasive way for early Parkinson’s diagnosis

The genetic analysis of a blood sample could become a tool for the early diagnosis of Parkinson's disease, according to an exploratory study led by researchers from the Miguel Hernández University of Elche (UMH).

27 Oct 2025

New AI model can identify treatments that reverse disease states in cells

In a move that could reshape drug discovery, researchers at Harvard Medical School have designed an artificial intelligence model capable of identifying treatments that reverse disease states in cells.

10 Sep 2025

Can honey protect your brain? Study reviews its potential against Alzheimer's

This review examined 27 preclinical studies on honey and Alzheimer’s disease, showing honey’s bioactive compounds counter oxidative stress, inflammation, and amyloid buildup. Despite promising lab results, no human trials exist, underscoring the need for clinical research.

1 Sep 2025

How plant compounds could target Alzheimer’s disease from multiple angles

This review highlights how dietary polyphenols modulate Alzheimer’s disease biology through antioxidant, anti-inflammatory, and multi-target mechanisms, supported by in-silico docking analyses. Despite promise, challenges in bioavailability and brain delivery remain key hurdles to clinical translation.

31 Aug 2025

Metabolic syndrome linked to higher risk of Parkinson's disease

Having a larger waistline, high blood pressure and other risk factors that make up metabolic syndrome is associated with an increased risk of Parkinson's disease, according to a study published on August 20, 2025, in Neurology, the medical journal of the American Academy of Neurology.

20 Aug 2025

Heavy smoking linked to atrophy in Alzheimer’s brain regions

MRI findings indicate that smoking is linked to reduced brain volume, raising concerns about dementia risk, especially with higher body mass index.

25 Jul 2025

Redefining Alzheimer’s development by mapping disease sequences

UCLA's study identifies distinct Alzheimer's disease trajectories, emphasizing the role of shared risk factors in early detection and targeted interventions.

9 Jul 2025

Targeting ST6Gal-I shows promise in reducing Alzheimer’s disease pathology

A recent study published in Engineering has provided novel insights into the involvement of α2,6-sialylation in Alzheimer's disease (AD), revealing that the ablation of α2,6-sialyltransferase-I (ST6Gal-I), an enzyme responsible for α2,6-sialylation, can downregulate BACE1 expression and suppress the production of amyloid-β42 (Aβ42) plaques, which are hallmarks of AD.

20 Jun 2025

Why Alzheimer’s DNA tests don’t treat all populations equally

A major global study tested whether European-derived polygenic risk scores (PGS) for Alzheimer’s disease can predict risk across diverse populations. While PGS performed well in many groups, it was less accurate in individuals of sub-Saharan African and Indian ancestry, highlighting the urgent need for more inclusive genetic data.

19 Jun 2025

Equal access, unequal impact: Parkinson’s hits minorities harder in the UK

Researchers in East London found that South Asian and Black Parkinson’s disease patients experience more severe motor and cognitive symptoms than White patients. Despite similar access to diagnosis, disparities persist, highlighting the need for more inclusive and culturally sensitive care.

18 Jun 2025

Black tea helps in one Parkinson’s type, but soda and pesticides worsen another

A large longitudinal study found that pesticide exposure and caffeinated soda intake were linked to more severe motor symptoms in idiopathic Parkinson’s disease (iPD). In contrast, black tea consumption was associated with milder symptoms in patients with LRRK2-related Parkinson’s disease (LRRK2-PD).

16 Jun 2025

UC Irvine researchers uncover altered RNA processing in ALS

UC Irvine researchers conducted a study to better understand the molecular basis of amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder in which patients lose the ability to move, becoming weak and wheelchair bound before dying because they can no longer breathe.

3 Jun 2025

Ghrelin receptor identified as key to easing constipation in Parkinson’s patients

Considered the natural "hunger hormone", Ghrelin could be the key to preventing debilitating chronic constipation experienced by people living with Parkinson's disease, University of Queensland researchers have found.

28 May 2025

New fruit fly study shows the whole-body impact of Alzheimer’s disease

While Alzheimer's disease is mostly considered a disorder of the brain, emerging evidence suggests that the condition also affects other organs of the body.

16 May 2025

New approach directly combats the progression of Alzheimer’s and ALS

Scientists at Northwestern University have developed a new approach that directly combats the progression of neurodegenerative diseases like Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

14 May 2025

RNA editing enzyme found to trigger neuroinflammation in Parkinson's

Parkinson's disease (PD) is a neurodegenerative disorder in which the α-synuclein protein abnormally aggregates within brain cells, causing neuronal damage.

3 May 2025

New biomarker offers hope for early Parkinson’s diagnosis

A misfolded protein facilitates reliable diagnosis even in the early stages of Parkinson’s disease in body fluids.

25 Apr 2025

Blood test detects Parkinson’s years before symptoms appear using RNA markers

A new study identifies a blood-based biomarker that detects pre-symptomatic Parkinson’s disease by measuring the ratio of specific nuclear and mitochondrial transfer RNA fragments. The test outperforms standard clinical tools and may also reflect disease mechanisms related to impaired protein synthesis.

14 Apr 2025

Proteins linked to Parkinson's and ALS found to protect mitochondria

Scientists at Johns Hopkins Medicine say they have discovered how a group of proteins linked to Parkinson's disease and amyotrophic lateral sclerosis act as "guardians" of mitochondria, small organelles, or subunits, within a cell that make and store energy and are found in almost all plants and animals.

8 Apr 2025

Many individuals with Niemann-Pick disease lack neutralizing antibodies against AAV2 or AAV9

A new study in the peer-reviewed journal Human Gene Therapy showed that more than half of individuals with Niemann-Pick disease, type C1 (NPC1) who were tested lacked neutralizing antibodies against either adeno-associated virus (AAV) 2 or AAV9.

10 Mar 2025