Orthopaedic News and Research

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Muscle stem cells show ability to transform and heal broken bones

When bones break and there is extreme tissue loss--such as after a car accident or a battlefield injury--current treatments don't often lead to effective healing.

18 Aug 2025

Scaffold-free cellular spheroids generate integrated osteochondral grafts

A new study in the peer-reviewed journal Tissue Engineering, Part A demonstrates the potential to produce cellular spheroids, from a clinically relevant embryonic stem cell derived mesenchymal stem cell (ES-MSC) source, to generate scaffold-free chondrogenic or osteochondrogenic graft tissues.

14 Aug 2025

New mouse model reveals key role of osteocytes in osteogenesis imperfecta

Osteogenesis imperfecta (OI) refers to a group of rare genetic bone disorders that results in the formation of fragile bones. In patients with OI, the matrix that makes up the bone has been found to be abnormal, leading to an increased risk of fractures.

13 Aug 2025

UCLA researchers decode the muscle mechanics behind blinking

A blink of an eye seems natural and instantaneous, but is it? Without a functioning eyelid, the eye can become dry, irritated and eventually lose the ability to see clearly.

8 Aug 2025

Researchers discover amyloid protein buildup in bone marrow of aging mice

A recent study led by a team of researchers at The Johns Hopkins University School of Medicine examining aging mice has provided what is believed to be the first evidence that amyloid beta protein-small, sticky protein fragment found in people with Alzheimer's disease (AD)-particles build up in the bone marrow of the animals, although not in the exact same form as the large, dense plaques found in the brains of people with Alzheimer's disease.

5 Aug 2025

Immune molecule found to play a key role in regulating inflammation in rheumatoid arthritis

Researchers at Kyoto University have discovered that an immune molecule found only in primates, called IGFL2, plays a key role in regulating inflammation in rheumatoid arthritis (RA).

1 Aug 2025

Spinning's positive impact on hip osteoarthritis uncovered

A new study by Bournemouth University (BU) and University Hospitals Dorset (UHD) has revealed the benefits of spinning for patients with hip osteoarthritis. The study was funded by the National Institute for Health Research (NIHR) and will be published in Lancet Rheumatology at 23:30 UK time on Thursday 31st July 2025.

1 Aug 2025

3D-printed implant offers a potential new route to repair spinal cord injuries

A research team at RCSI University of Medicine and Health Sciences has developed a 3-D printed implant to deliver electrical stimulation to injured areas of the spinal cord, offering a potential new route to repair nerve damage.

15 Jul 2025

Myopenia identified as key contributor to muscle loss in rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects individuals across all ages and genders.

11 Jul 2025

AI system estimates bone density using routine X-ray images

Investigators have developed an artificial intelligence-assisted diagnostic system that can estimate bone mineral density in both the lumbar spine and the femur of the upper leg, based on X-ray images.

9 Jul 2025

$New initiative at Mount Sinai enhances treatment for osteoporosis-related fractures$

New initiative at Mount Sinai enhances treatment for osteoporosis-related fractures

The Leni and Peter W. May Department of Orthopedic Surgery at the Icahn School of Medicine at Mount Sinai has implemented the American Orthopaedic Association's Own the Bone® program, joining more than 300 health care institutions nationwide to help better identify, evaluate, and treat patients who experience an osteoporosis- or low bone density-related fractures.

8 Jul 2025

Common diabetes drug can reduce the pain of people with knee osteoarthritis and obesity

A common diabetes drug can reduce the pain of people with knee osteoarthritis and overweight or obesity, possibly delaying the need for knee replacements, Monash University-led research has found.

24 Apr 2025

Muscle quality emerges as crucial factor in hip replacement recovery

Hip replacement surgery, or total hip arthroplasty (THA), can lessen pain and improve function in individuals with hip osteoarthritis, but some patients continue to experience long-term physical deficits-including muscle weakness, decreased functional mobility, and increased fall risk-after the procedure.

23 Apr 2025

Targeting zombie cells could revolutionize chronic back pain treatment

In a preclinical study led by McGill University researchers, two drugs targeting "zombie cells" have been shown to treat the underlying cause of chronic low back pain. The condition affects millions of people worldwide.

22 Apr 2025

3D-printed hydrogel offers new hope for meniscus tear treatment

Meniscus tears are common knee injuries that have long frustrated patients and doctors due to limited repair options.

28 Mar 2025

3D-printed hydrogel offers new hope for meniscus tear treatment

Meniscus tears are common knee injuries that have long frustrated patients and doctors due to limited repair options.

25 Mar 2025

Altered knee joint movement after ACL surgery could contribute to early-onset knee osteoarthritis

Some individuals who have had anterior-cruciate-ligament reconstruction (ACLR), the kind of surgery often performed on athletes' knees, may develop early-onset knee osteoarthritis.

19 Mar 2025

Long-term study shows knee replacements last lifetime for active young adults

A 40-year study by Hospital for Special Surgery (HSS) researchers has found that active young adults who underwent total knee replacement were unlikely to require knee replacement revision in their lifetime, according to a new study shared today in a podium presentation at the American Academy of Orthopaedic Surgeons 2025 Annual Meeting.

14 Mar 2025

Earlier ACL surgery may reduce risk of knee osteoarthritis

A preclinical study by HSS investigators found that earlier anterior cruciate ligament (ACL) reconstruction led to lower immune cell activity, less inflammation and fewer joint changes associated with knee osteoarthritis compared to delayed surgery.

12 Mar 2025

$Study finds early weight bearing safe for ankle fracture recovery$

Study finds early weight bearing safe for ankle fracture recovery

A new study from the University of Missouri School of Medicine suggests putting weight on an ankle – also known as weight bearing – within three weeks of recovering from a surgically repaired fracture is safe.

26 Feb 2025