Proteostasis News and Research

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Each mammalian cell contains up to 20,000 proteins, all of which must be maintained and regulated. Proteostasis is a complex pathway that functions to maintain all of the proteins within and around a cell.

Breakthrough in protein homeostasis offers potential for preventing Alzheimer’s

Scientists have uncovered a powerful ally in the fight against neurodegenerative diseases: a nucleolar complex that plays a pivotal role in maintaining cellular health through protein homeostasis (proteostasis), by which cells maintain the balance and proper functioning of their proteins.

3 Jan 2025

Lithocholic acid enhances health and lifespan, mimicking calorie restriction

Lithocholic acid (LCA), a metabolite induced by calorie restriction (CR), activates AMPK and mimics anti-aging benefits. A recent study highlights LCA's role in improving muscle performance, glucose tolerance, and lifespan in aged organisms.

1 Jan 2025

Ketone body β-hydroxybutyrate restores protein balance and targets Alzheimer’s-linked aggregates

Scientists identify β-hydroxybutyrate as a key regulator of protein solubility, offering a novel pathway to combat neurodegeneration in aging and Alzheimer’s disease.

4 Dec 2024

Ketone metabolism redefines protein quality control in aging brains

Ketone bodies, produced by the body to provide fuel during fasting, have roles in regulating cellular processes and aging mechanisms beyond energy production. Research at the Buck Institute shows that ketone bodies can best be understood as powerful signaling metabolites affecting brain function in aging and Alzheimer's disease.

3 Dec 2024

New protein found to protect cells from age-related decline

McMaster University researchers have discovered a previously unknown cell-protecting function of a protein, which could open new avenues for treating age-related diseases and lead to healthier aging overall.

18 Oct 2024

CheekAge: Next-gen epigenetic clock accurately predicts mortality risk

Researchers developed CheekAge, an epigenetic clock based on buccal cells, and found it predicted mortality risk with significant accuracy. This study validates CheekAge as a reliable aging biomarker, outperforming first-generation clocks.

6 Oct 2024

New genetic mutation may cause a form of early-onset Parkinsonism

A team of scientists led by Prof. Patrik Verstreken (VIB-KU Leuven) has identified a new genetic mutation that may cause a form of early-onset Parkinsonism.

26 Sep 2024

Researchers identify drug with anti-aging effects

Aging is an inevitable phenomenon and is accompanied by several comorbidities. To this end, research into the effects of aging has become paramount, and scientists are looking for ways to slow down aging and its detrimental impact on the human body.

25 Sep 2024

Blood microRNAs can predict conversion from mild cognitive impairment to dementia due to Alzheimer’s disease

This study identifies serum miRNA signatures as promising biomarkers for Alzheimer's, enhancing prediction of MCI conversion to AD with clinical relevance.

23 Sep 2024

PhoreMost introduces GlueSEEKER platform for discovery of molecular glue degraders

PhoreMost Ltd., a leading UK biopharmaceutical company unlocking the next generation of drug targets, today announced the introduction of GlueSEEKER™.

From PhoreMost 22 May 2024

Vitamin D shows promise in targeting aging's biological mechanisms, study finds

What is currently known about the potential effect of vitamin D (VitD) on modulating some hallmarks of aging.

26 Mar 2024

Magnesium's pivotal role in slowing aging's impact

Review highlights magnesium's critical role in mitigating aging hallmarks, including telomere attrition, genomic instability, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, cellular senescence, and stem cell exhaustion, suggesting that maintaining adequate magnesium levels could support healthy aging.

13 Feb 2024

New method traces primed resistance in cancer via sister cells

In many cancers, such as ovarian cancer, each round of chemotherapy kills the majority of cancer cells, while a small population of them survives through treatment.

12 Feb 2024

Researchers evaluate possible mitochondrial factors in Alzheimer's pathogenesis

A group of authors critically evaluated and interpreted the evidence linking mitochondrial dysfunction and metabolic changes to the pathogenesis of Alzheimer's disease (AD).

5 Dec 2023

Data, Design, and Discovery: Andrew Buchanan's Impact on Biologics Innovation

Andrew Buchanan on the Future of Biologics and AI

10 Nov 2023

Can coffee silverskin be used to prevent aging?

The anti-aging properties of coffee silverskin extracts (CSE).

13 Oct 2023

Unveiling the role of astrocyte-derived LCN2 in neurodegenerative disease progression

Researchers reviewed existing data on the neurodegenerative effects of astrocyte-derived lipocalin-2 (LCN-2).

4 Oct 2023

New small molecule drug targets active state of cancer-causing KRAS mutant

A new small molecule drug helps to bind the naturally occurring cellular chaperone cyclophilin A (CYPA) to the active state of the cancer-causing mutant KRASG12C, disrupting oncogenic signaling and tumor growth in several models of human cancer.

17 Aug 2023

Study reveals how p62 bodies control redox-independent stress response

Cellular stress, or oxidative stress, occurs when there is a buildup of reactive oxygen species (ROS), which interferes with cellular mechanisms and can even cause damage to proteins, lipids, and DNA.

12 Jun 2023

How does tirzepatide stimulate insulin secretion?

Tirzepatide, a drug approved for diabetes and on the fast track for approval as a weight loss therapy, works through a unique ability to activate two different mechanisms the body uses to control insulin secretion and energy balance, Duke Health researchers report.

6 Jun 2023