Psychosis News and Research

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Psychosis means abnormal condition of the mind, and is a generic psychiatric term for a mental state often described as involving a "loss of contact with reality". People suffering from psychosis are said to be ''psychotic.''

Study analyzes alterations in the cerebral cortex in people with psychosis

Researchers at the University of Seville have analyzed alterations in the cerebral cortex in people suffering from psychosis.

20 Feb 2026

How GLP-1 drugs affect the body beyond weight loss and glucose control

This review evaluates the safety profile of glucagon-like peptide-1 receptor agonists and related incretin therapies used for obesity and type 2 diabetes. It highlights common gastrointestinal effects, rare but debated risks, and areas where further long-term safety data are still needed.

18 Feb 2026

Short-duration psychedelic therapy shows promise for major depression treatment

A phase IIa randomized trial found that intravenous dimethyltryptamine (DMT) with structured psychological support produced rapid reductions in depressive symptoms in adults with major depressive disorder. Improvements were statistically significant versus placebo at two weeks, with mostly mild-to-moderate adverse events and the need for larger confirmatory studies emphasized.

17 Feb 2026

Discontinuing antidepressants during pregnancy raises psychiatric risks

Pregnant patients who stopped taking their antidepressant medication during pregnancy were almost twice as likely to experience a mental health emergency compared with pregnant patients who continued taking their prescription, according to new research presented today at the Society for Maternal-Fetal Medicine (SMFM) 2026 Pregnancy Meeting.

11 Feb 2026

Psychotic disorders increasingly diagnosed in younger Canadians

A new study suggests that people born more recently are being diagnosed with psychotic disorders (e.g., schizophrenia) more often and at younger ages compared with people born earlier.

3 Feb 2026

Study reveals rising psychosis rates among younger generations

People born more recently are being diagnosed with psychotic disorders (e.g., schizophrenia) more often and at younger ages than people born earlier, suggests a large study of more than 12 million people in Ontario, published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.250926.

2 Feb 2026

King’s researchers help transform UK mental health research infrastructure

King’s researchers will help transform mental health data, clinical trials and industry partnerships as part of the UK Government’s Mental Health Goals programme.

30 Jan 2026

Study isolates mania-specific genetic architecture in bipolar disorder

Researchers at King's College London and the University of Florence have, for the first time, identified the specific genetic blueprint of mania, the defining feature of bipolar disorder.

27 Jan 2026

Central reference database launched to categorize and coordinate mental health biomarker research

Psychiatrists and neuroscientists are taking a major step toward objective mental health diagnosis by launching a central reference database for the classification and communication of mental health biomarker research.

19 Jan 2026

Study finds growing long-term antipsychotic prescribing in elderly dementia patients

When agitated dementia patients wander or shout through the night, families and caregivers understandably feel the need to treat this frightening and potentially dangerous behavior. Antipsychotic medications are often resorted to with such patients, contributing to increases in antipsychotic treatment rates among older people.

16 Jan 2026

Smoking cessation drug shows promise for treating cannabis use disorder

A new randomized controlled trial has found promising evidence that the smoking cessation medication varenicline (Chantix/Champix) can help people with cannabis use disorder (CUD) to reduce cannabis use.

15 Jan 2026

Researchers map how brain networks differ in individuals at high clinical risk for psychosis

Researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), and NHG Health's Institute of Mental Health (IMH) have mapped how brain networks differ in individuals at Clinical High Risk (CHR) for psychosis, providing a new perspective on the mechanisms underlying the disease onset.

10 Dec 2025

Study reveals the overlooked mental health challenges faced by new parents

Intrusive thoughts and psychotic-like experiences among new parents are far more common than previously thought - according to new research from the University of East Anglia.

2 Dec 2025

Moderate coffee intake linked to slower biological aging in people with severe mental illness

Drinking a maximum of 3-4 cups of coffee a day may slow the 'biological' ageing of people with severe mental illness, by lengthening their telomeres-indicators of cellular ageing-and giving them the equivalent of 5 extra biological years, compared with non-coffee drinkers, finds research published in the open access journal BMJ Mental Health.

25 Nov 2025