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Sphere Fluidics announces enhanced Cyto-Mine capability and performance

Sphere Fluidics, a company developing single-cell analysis systems, today announced it has enhanced the performance of its Cyto-Mine® System.

From Fluidic Sciences and Sphere Bio 17 May 2021

New translational research platform launched to study rare cancers

The University of Texas MD Anderson Cancer Center and the Broad Institute of MIT and Harvard today announced the launch of a new translational research platform to study rare cancers and develop a first-of-its-kind resource for the scientific community.

11 May 2021

Researchers design compounds that prevent SARS-CoV-2 entry in human lung cells

Researchers have designed a new class of TMPRSS2 inhibitors that have shown broad antiviral activity against coronaviruses, including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

11 May 2021

Could in vitro glycoengineering help produce better SARS-CoV-2 spike candidates for vaccine research?

A vexing problem in the development of vaccines has been the need to achieve the right glycosylation profile for the viral antigens. A new study, recently released as a preprint on the bioRxiv* server, shows how a sequential cell-free approach produced complex N-glycans from simpler types, in a one-pot reaction.

4 May 2021

Furin cleavage site crucial in SARS-CoV-2 for viral transmission in ferrets, finds study

Researchers based at Imperial College London, UK, have recently highlighted the effects of these deleterious CS mutations through a ferret animal model, demonstrating that furin cleavage sites are a necessary component in the virus’ ability to replicate.

30 Apr 2021

Scientists design 'smart' cellular biosensors for detecting SARS-CoV-2 spike

New research led by Hana El-Samad of the University of California, San Francisco, and the Chan-Zuckerberg Biohub confirmed the beneficial use of an antiviral therapeutic called SARSNotch, which uses a combination of the SynNotch platform and de-novo designed protein binders. SARSNotch uses sentinel T cells to detect and mount a genetic response toward the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein.

28 Apr 2021

Researchers identify genetic abnormalities that drive invasiveness in head and neck cancer

A multi-institutional team of researchers has identified both the genetic abnormalities that drive pre-cancer cells into becoming an invasive type of head and neck cancer and patients who are least likely to respond to immunotherapy.

26 Apr 2021

Maintaining swimming pools in line with UK guidelines eliminates SARS-CoV-2 risk

Researchers in the UK have conducted a study showing that maintaining swimming pool water in accordance with UK guidelines is sufficient to eliminate the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) being transmitted between bathers.

21 Apr 2021

SARS-CoV-2 nucleoprotein can trigger α-synuclein amyloid fibril formation

A new study, released as a preprint on the bioRxiv* server, casts some light on the pathogenesis of acute and subacute neurological complications associated with COVID-19.

19 Apr 2021

Researchers develop an effective strategy to fight against chronic myelomonocytic leukemia

Leukemias are debilitating cancers of the hematopoietic or blood-forming cells of the bone marrow. Now, researchers at Tokyo Medical and Dental University describe an ingenious strategy against chronic myelomonocytic leukemia (CMML) wherein an antibody-drug conjugate (ADC) comprising a cytotoxic drug payload linked to an antibody that selectively targets specific cell lines effectively blocks malignant cell proliferation at source.

16 Apr 2021

CityU researchers identify super-enhancers that stimulate the activity of breast cancer genes

Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with a high fatality rate. Currently, chemotherapy is the major treatment option, but the clinical result is unsatisfactory.

15 Apr 2021

P681 mutation has little impact on transmissibility in the SARS-CoV-2 UK variant, finds study

A new preprint, recently released on the bioRxiv* server, explores the impact of a single mutation, the P681H mutation, on the transmissibility of the virus.

12 Apr 2021

COVID19's cytokine storm ushers in a local complement storm in the lungs

A new study published in the journal Science Immunology analyzed lung epithelial cells from patients infected with COVID-19 and found the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces the complement system as a dangerous weapon for viral infection.

12 Apr 2021

Screening for SARS-CoV-2 non-structural protein 14 inhibitors

In a paper recently uploaded to the preprint server bioRxiv* by Diffley et al. (April 8th, 2021), inhibitors of one essential SARS-CoV-2 non-structural protein are explored, with four compounds, in particular, identified as potential antiviral leads that exhibit synergistic effects with antiviral drug remdesivir.

12 Apr 2021

New polypeptide could provide universal protection against coronaviruses

Researchers in the United States have developed an inhibitor of the spike protein found on the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that limits its formation in host human cells that would otherwise be the source of newly generated virions.

11 Apr 2021

Scientists compare DNA damaging properties of chemicals from vape products and cigarettes

Imperial Brands scientists have utilized Toxys' ToxTracker suite of stem-cell based in-vitro assays, which provide mechanistic insight into the potential DNA damaging properties of chemicals, comparing vape e-liquid samples and their aerosols to combustible cigarette smoke.

9 Apr 2021

Researchers Identify potent small molecule inhibitors against SARS-CoV-2

A team of scientists from the USA and Sweden has recently screened 8 million small molecule inhibitors against SARS-CoV-2.

5 Apr 2021

Scientists use a novel two-step method to track receptor proteins

The neurons in our nervous system "talk" to each other by sending and receiving chemical messages called neurotransmitters.

3 Apr 2021

Scientists identify nine potential new COVID-19 treatments

A team led by scientists in the Perelman School of Medicine at the University of Pennsylvania has identified nine potential new COVID-19 treatments, including three that are already approved by the Food and Drug Administration (FDA) for treating other diseases.

2 Apr 2021

Researchers offer large-scale screening of potential broad-spectrum SARS-CoV-2 antivirals

A new study describes the identification of new compounds from a library, with inhibitory activity against several coronaviruses. This study shows the utility of this method, besides identifying compounds that not only inhibit viral shedding in SARS-CoV-2 cultures, but have an immunomodulatory effect that may be useful in mitigating the damaging cytokine storm typical of severe or critical COVID-19.

2 Apr 2021

Cell Line News and Research

Sphere Fluidics announces enhanced Cyto-Mine capability and performance

New translational research platform launched to study rare cancers

Researchers design compounds that prevent SARS-CoV-2 entry in human lung cells

Could in vitro glycoengineering help produce better SARS-CoV-2 spike candidates for vaccine research?

Furin cleavage site crucial in SARS-CoV-2 for viral transmission in ferrets, finds study

Scientists design 'smart' cellular biosensors for detecting SARS-CoV-2 spike

Researchers identify genetic abnormalities that drive invasiveness in head and neck cancer

Maintaining swimming pools in line with UK guidelines eliminates SARS-CoV-2 risk

SARS-CoV-2 nucleoprotein can trigger α-synuclein amyloid fibril formation

Researchers develop an effective strategy to fight against chronic myelomonocytic leukemia

CityU researchers identify super-enhancers that stimulate the activity of breast cancer genes

P681 mutation has little impact on transmissibility in the SARS-CoV-2 UK variant, finds study

COVID19's cytokine storm ushers in a local complement storm in the lungs

Screening for SARS-CoV-2 non-structural protein 14 inhibitors

New polypeptide could provide universal protection against coronaviruses

Scientists compare DNA damaging properties of chemicals from vape products and cigarettes

Researchers Identify potent small molecule inhibitors against SARS-CoV-2

Scientists use a novel two-step method to track receptor proteins

Scientists identify nine potential new COVID-19 treatments

Researchers offer large-scale screening of potential broad-spectrum SARS-CoV-2 antivirals

Automated colony picking: Comparing technologies for efficient clone screening eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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