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Reverse phenotyping shows reactive T cell profiles in SARS-CoV-2 infection

A new study appearing as a preprint on the medRxiv* browser in December 2020 employs reverse phenotyping technology to explore T cell responses in COVID-19.

10 Dec 2020

FASLG gene may drive cytokine-linked adverse COVID-19 outcomes with age

A new study published on the preprint server bioRxiv in December 2020 reveals the role played by certain genetic factors in this group, in particular the FASLG gene belonging to the tumor necrosis factor (TNF) family.

8 Dec 2020

Study: Home health care provides support, improves recovery for COVID-19 patients

Survivors of COVID-19 are a vulnerable population who often have health ramifications from their illness and hospital stay. Upon returning home from acute care, large proportions of survivors experience functional dependencies, pain, dyspnea, and exhaustion.

24 Nov 2020

Anger after North Dakota Governor asks COVID-positive health staff to stay on job

Nurse Leslie McKamey has gotten used to the 16-hour shifts, to skipping lunch, to the nightly ritual of throwing all her clothes in the laundry and showering as soon as she walks through the door to avoid potentially infecting her children.

18 Nov 2020

Burnout has greater impact on work stress than vice versa

Work stress and burnout are mutually reinforcing. Surprisingly, the effect of work stress on burnout is much smaller than the effect of burnout on work stress.

10 Nov 2020

Wearing a face mask during strenuous workouts does not hinder breathing

A new University of Saskatchewan study has found that exercise performance and blood and muscle oxygen levels are not affected for healthy individuals wearing a face mask during strenuous workouts.

5 Nov 2020

Physical stress caused by interruptions in workplace

ETH researchers have used an experiment in a simulated group office environment to show for the first time that the body produces more stress hormones when people are repeatedly interrupted at work.

28 Oct 2020

Researchers assess molecular basis of SARS-CoV-2 severity and poor outcomes in lung disease

A recent study published on the preprint server bioRxiv in October 2020 shows that in patients with chronic lung disease, the pattern of gene expression in the different types of cell changes such that the lung epithelium is prepared to tackle SARS-CoV-2 infection. Also, the altered gene programs have an impact on the immune response.

22 Oct 2020

Study uncovers the mechanism behind bone marrow failure in Fanconi anemia

Fanconi anaemia (FA) is a genetic disease affecting small children characterized by bone-marrow failure, developmental abnormalities and predisposition to multiple forms of cancer.

14 Oct 2020

Researchers identify a mechanism to prevent hair loss

An international research group headed by Associate Professor Sara Wickström at the University of Helsinki has identified a mechanism that is likely to prevent hair loss.

13 Oct 2020

CAR T cell therapy can predict treatment response in patients with large B-cell lymphoma

Researchers at The University of Texas MD Anderson Cancer Center have identified molecular and cellular characteristics of anti-CD19 CAR T cell infusion products associated with how patients with large B-cell lymphoma (LBCL) respond to treatment and develop side effects.

6 Oct 2020

Ludwig study uncovers a nutritional approach to improve cancer immunotherapy

A Ludwig Cancer Research study has uncovered a mechanism by which the tumor's harsh internal environment sabotages T lymphocytes, leading cellular agents of the anticancer immune response.

5 Oct 2020

Research can help better manage body temperature regulation and hydration in older adults

Our ability to regulate body temperature and keep our bodies from becoming dehydrated declines as we get older. New research published today in The Journal of Physiology improves our understanding of the relation between temperature regulation and dehydration.

30 Sep 2020

New mechanism that prevents hair loss identified

A team of researchers from Cologne and Helsinki has discovered a mechanism that prevents hair loss: hair follicle stem cells, essential for hair to regrow, can prolong their life by switching their metabolic state in response to low oxygen concentration in the tissue.

28 Sep 2020

AI used to define the cytokine storm implicated in fatal COVID-19

A new study published on the preprint server bioRxiv* in September 2020 reports the use of artificial intelligence (AI) to identify an invariant or universal host immune response found in all viral pandemics so far. The association of this response with severe COVID-19 phenotypes indicates a new understanding of the human immune response in viral pandemics.

24 Sep 2020

Researchers explore clinical and biological aspects of myalgic encephalomyelitis/chronic fatigue syndrome

One of the major symptoms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is post-exertional malaise (PEM), the worsening of symptoms after physical or mental activities.

23 Sep 2020

High levels of blood clotting factor V in severe COVID‐19 associated with worse outcomes

Patients hospitalized with severe COVID-19 infections who have high levels of the blood clotting protein factor V are at elevated risk for serious injury from blood clots such as deep vein thrombosis or pulmonary embolism, investigators at Massachusetts General Hospital (MGH) have found.

8 Sep 2020

Novel markers may predict patient response to immune checkpoint inhibitors

For many individuals with different types of cancer, immune checkpoint inhibitors can effectively boost their immune system to fight their disease, but not all patients benefit from these medications.

7 Sep 2020

As threat of valley fever grows beyond the Southwest, push is on for vaccine

One New Year's Day, Rob Purdie woke up with a headache that wouldn't quit. Vision problems, body aches and a slight fever followed. At the emergency room, the Bakersfield, California, resident was given antibiotics, which didn't touch his symptoms.

4 Sep 2020

Research compares T cell responses to SARS-CoV-2 and influenza

As the COVID-19 pandemic continues to grow, scientists are focusing on understanding how the host immune system responds to the virus in order to better shape public health responses and develop effective vaccines. A new study published on the preprint server medRxiv in September 2020 reports the T cell memory response to the SARS-CoV-2 spike protein, recombinant nucleocapsid protein, and other pooled peptides derived from convalescent patients.

3 Sep 2020